Successful Treatment of Fulminant Community-Acquired Pseudomonas aeruginosa Necrotizing Pneumonia in a Previously Healthy Young Man

Kei Kunimasa; Tadashi Ishida; Soichiro Kimura; Maki Tanaka; Yuichi Kouyama; Shigeki Yamashita; Mitsunori Morita; Hiromasa Tachibana; Fumiaki Tokioka; Akihiro Ito; Chisato Sumi; Kazuhiro Tateda

doi:10.2169/internalmedicine.51.7596

CASE REPORTS

Successful Treatment of Fulminant Community-Acquired Pseudomonas aeruginosa Necrotizing Pneumonia in a Previously Healthy Young Man

Kei Kunimasa, Tadashi Ishida, Soichiro Kimura, Maki Tanaka, Yuichi Kouyama, Shigeki Yamashita, Mitsunori Morita, Hiromasa Tachibana, Fumiaki Tokioka, Akihiro Ito, Chisato Sumi, Kazuhiro Tateda

Author information

Kei Kunimasa
Department of Respiratory Medicine, Kurashiki Central Hospital, Japan
Division of Genetics, Kobe University Graduate School of Medicine, Japan
Tadashi Ishida
Department of Respiratory Medicine, Kurashiki Central Hospital, Japan
Soichiro Kimura
Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Japan
Maki Tanaka
Department of Respiratory Medicine, Kurashiki Central Hospital, Japan
Yuichi Kouyama
Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Japan
Shigeki Yamashita
Department of Anesthesia, Kurashiki Central Hospital, Japan
Mitsunori Morita
Department of Medical Research and Education, Kurashiki Central Hospital, Japan
Hiromasa Tachibana
Department of Respiratory Medicine, Kurashiki Central Hospital, Japan
Fumiaki Tokioka
Department of Respiratory Medicine, Kurashiki Central Hospital, Japan
Akihiro Ito
Department of Respiratory Medicine, Kurashiki Central Hospital, Japan
Chisato Sumi
Department of Anesthesia, Kurashiki Central Hospital, Japan
Kazuhiro Tateda
Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Japan

Keywords: community-acquired pneumonia, Pseudomonas aeruginosa, severe pneumonia

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 17 Pages 2473-2478

DOI https://doi.org/10.2169/internalmedicine.51.7596

Details

Abstract

This report presents a case of fulminant community-acquired Pseudomonas aeruginosa necrotizing pneumonia in a previously healthy young man, including an analysis of the virulence of the P.aeruginosa isolated from the patient. The patient was successfully treated with intensive care and antibiotic treatment. This study analyzed the pathogenicity of the isolated strain both in vivo (using a mouse pneumonia model) and in vitro (using biofilm production), but could not explain how an otherwise healthy young man developed such severe community-acquired P.aeruginosa pneumonia. Although rare in community-acquired pneumonia, P.aeruginosa infection should be considered in patients with severe rapidly progressive pneumonia.

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