Hepatocellular Carcinoma with Peritoneal Dissemination which was Regressed during Vitamin K2 and Vitamin E Administration

Toshiyuki Otsuka; Satoshi Hagiwara; Hiroki Tojima; Hiroaki Yoshida; Tetsushi Takahashi; Kazumi Nagasaka; Shinichi Tomioka; Tetsu Ando; Kunio Takeuchi; Takayuki Kori; Yoshihiro Ohno; Satoru Kakizaki; Hitoshi Takagi; Masatomo Mori

doi:10.2169/internalmedicine.46.6131

CASE REPORTS

Hepatocellular Carcinoma with Peritoneal Dissemination which was Regressed during Vitamin K2 and Vitamin E Administration

Toshiyuki Otsuka, Satoshi Hagiwara, Hiroki Tojima, Hiroaki Yoshida, Tetsushi Takahashi, Kazumi Nagasaka, Shinichi Tomioka, Tetsu Ando, Kunio Takeuchi, Takayuki Kori, Yoshihiro Ohno, Satoru Kakizaki, Hitoshi Takagi, Masatomo Mori

Author information

Toshiyuki Otsuka
Department of Internal Medicine, Tone Chuo Hospital
Satoshi Hagiwara
Department of Internal Medicine, Tone Chuo Hospital
Hiroki Tojima
Department of Internal Medicine, Tone Chuo Hospital
Hiroaki Yoshida
Department of Internal Medicine, Tone Chuo Hospital
Tetsushi Takahashi
Department of Internal Medicine, Tone Chuo Hospital
Kazumi Nagasaka
Department of Internal Medicine, Tone Chuo Hospital
Shinichi Tomioka
Department of Internal Medicine, Tone Chuo Hospital
Tetsu Ando
Department of Surgery, Tone Chuo Hospital
Kunio Takeuchi
Department of Surgery, Tone Chuo Hospital
Takayuki Kori
Department of Surgery, Tone Chuo Hospital
Yoshihiro Ohno
Department of Pathology, Tone Chuo Hospital
Satoru Kakizaki
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
Hitoshi Takagi
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
Masatomo Mori
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine

Keywords: hepatocellular carcinoma, vitamin K2, vitamin E

JOURNAL OPEN ACCESS

2007 Volume 46 Issue 11 Pages 711-716

DOI https://doi.org/10.2169/internalmedicine.46.6131

Details

Abstract

A 65-year-old man with positive anti-hepatitis C antibody and chronic renal failure was diagnosed as having a ruptured hepatocellular carcinoma (HCC) based on computed tomography (CT). The patient underwent transcatheter arterial embolization (TAE) for the HCC. After one more session of TAE, the patient underwent surgery. But HCC seeding peritoneally was pointed out. Vitamin K2 and vitamin E were administered as a conservative treatment. Six months after starting vitamins K2 and E, the primary tumor did not increase in size and intraperitoneal dissemination disappeared on CT with a significant decrease of alpha-fetoprotein. Even though this is only one case, combination therapy of vitamin K2 and E may induce growth suppression of HCC.

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