Emerging Minimal-change Nephrotic Syndrome in a Patient with Chronic Mesangial Proliferative Lupus Nephritis

Naoko Deji; Toshiro Sugimoto; Masami Kanasaki; Masahiro Aoyama; Yuki Tanaka; Masayoshi Sakaguchi; Yoshihiko Nishio; Takashi Uzu; Atsunori Kashiwagi

doi:10.2169/internalmedicine.46.0028

CASE REPORTS

Emerging Minimal-change Nephrotic Syndrome in a Patient with Chronic Mesangial Proliferative Lupus Nephritis

Naoko Deji, Toshiro Sugimoto, Masami Kanasaki, Masahiro Aoyama, Yuki Tanaka, Masayoshi Sakaguchi, Yoshihiko Nishio, Takashi Uzu, Atsunori Kashiwagi

Author information

Naoko Deji
Department of Internal Medicine, Shiga University of Medical Science
Toshiro Sugimoto
Department of Internal Medicine, Shiga University of Medical Science
Masami Kanasaki
Department of Internal Medicine, Shiga University of Medical Science
Masahiro Aoyama
Department of Internal Medicine, Shiga University of Medical Science
Yuki Tanaka
Department of Internal Medicine, Shiga University of Medical Science
Masayoshi Sakaguchi
Department of Internal Medicine, Shiga University of Medical Science
Yoshihiko Nishio
Department of Internal Medicine, Shiga University of Medical Science
Takashi Uzu
Department of Internal Medicine, Shiga University of Medical Science
Atsunori Kashiwagi
Department of Internal Medicine, Shiga University of Medical Science

Keywords: mesangial proliferative lupus nephritis, minimal-change nephropathy, nephrotic syndrome, systemic lupus erythematosus

JOURNAL OPEN ACCESS

2007 Volume 46 Issue 13 Pages 991-995

DOI https://doi.org/10.2169/internalmedicine.46.0028

Details

Abstract

A 41-year-old Japanese woman with a 25-year history of systemic lupus erythematosus was admitted because of abrupt onset of nephrotic syndrome and acute renal failure. Renal biopsy specimen showed only mild mesangial proliferative glomerulonephritis associated with mesangial deposition of immunoglobulins/complements. No significant immune deposits were found in the glomerular capillary walls, but mild foot process effacement was observed on electron microscopy. Further, two-month corticosteroid therapy improved her massive proteinuria and renal dysfunction, indicating that this patient showed minimal-change nephropathy superimposed on mesangial proliferative lupus nephritis.

Corresponding author

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