Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
ORIGINAL ARTICLES
Gender Difference in the Level of Highdensity Lipoprotein Cholesterol in Elderly Japanese Patients with Coronary Artery Disease
Haruki Musha, Akio Hayashi, Keisuke Kida, Eiji Takahashi, Kae Suzuki, Kensuke Kawasaki, Koji Inoue, Yoshihiro Akashi, Katsuhiko Tsuchiya, Masahiro Yamauchi, Tomoyuki Kunishima, Nobuyuki Hashimoto
Author information
Keywords: elderly Japanese women, highdensity lipoprotein cholesterol, coronary artery disease, gender difference
JOURNAL OPEN ACCESS

2006 Volume 45 Issue 5 Pages 241-245

Details
Download PDF (275K)
Download citation RIS

(compatible with EndNote, Reference Manager, ProCite, RefWorks)

BIB TEX

(compatible with BibDesk, LaTeX)

Text
How to download citation
Contact us
Abstract

Objective: Highdensity lipoprotein cholesterol (HDLC) levels are known to be reduced in the metabolic syndrome, but the HDLC profile of elderly patients with coronary artery disease (CAD) has not been well characterized. This study investigated the gender difference of HDLC levels in elderly Japanese patients with CAD.
Methods: Serum lipid data were analyzed retrospectively to assess sexrelated differences of the lipid profile, and to evaluate the effects of pharmacotherapy or physical exercise on hyperlipidemia.
Patients: A total of 163 elderly (≥65 years) outpatients with CAD (128 men aged 70.6±5.2 years and 35 women aged 74.1±6.0 years [mean±SD]) were investigated.
Results: The mean total cholesterol (TC), lowdensity lipoprotein cholesterol (LDLC), and triglyceride (TG) levels were similar in men and women, while the mean HDLC level was significantly higher in women than men (58.3±18.1 vs. 50.3±13.5 mg/dL; p=0.0064). The HDLC level was not significantly influenced by oral lipidlowering therapy or regular exercise in either sex. However, women without lipidlowering therapy had significantly higher HDLC levels than men with (p=0.0312) or without (p=0.0338) lipidlowering therapy, while women performing regular exercise had significantly higher HDLC levels than men with (p=0.0047) or without (p<0.001) regular exercise.
Conclusion: Elderly women with CAD have higher HDLC levels relative to their postmenopausal state than those of men with CAD. Low HDLC levels, unlike in men, may not be a major risk factor for CAD in elderly women.

Content from these authors
© 2006 by The Japanese Society of Internal Medicine
Previous article Next article
Favorites & Alerts

Recently viewed articles
Predecessor

Japanese Journal of Medicine

Share this page
feedback
 Top