Acute Lymphoblastic Leukemia with Isolated Adrenocorticotropic Hormone Deficiency

Hiroki YAMAGUCHI; Hiroyuki NAKAMURA; Yasutaka MAMIYA; Yasushi YAMAMOTO; Kenji TAJIKA; Hitoshi SUGIHARA; Seiji GOMI; Koiti INOKUCHI; Setuo HASEGAWA; Tamotsu SHIBAZAKI; Kazuo DAN; Ichiji WAKABAYASHI

doi:10.2169/internalmedicine.36.819

Hiroki YAMAGUCHI, Hiroyuki NAKAMURA, Yasutaka MAMIYA, Yasushi YAMAMOTO, Kenji TAJIKA, Hitoshi SUGIHARA, Seiji GOMI, Koiti INOKUCHI, Setuo HASEGAWA, Tamotsu SHIBAZAKI, Kazuo DAN, Ichiji WAKABAYASHI

Author information

Hiroki YAMAGUCHI
The Department of Internal Medicine, Nippon Medical School
Hiroyuki NAKAMURA
The Department of Internal Medicine, Nippon Medical School
Yasutaka MAMIYA
The Department of Internal Medicine, Nippon Medical School
Yasushi YAMAMOTO
The Department of Internal Medicine, Nippon Medical School
Kenji TAJIKA
The Department of Internal Medicine, Nippon Medical School
Hitoshi SUGIHARA
The Department of Internal Medicine, Nippon Medical School
Seiji GOMI
The Department of Internal Medicine, Nippon Medical School
Koiti INOKUCHI
The Department of Internal Medicine, Nippon Medical School
Setuo HASEGAWA
The Department of Internal Medicine, Nippon Medical School
Tamotsu SHIBAZAKI
The Department of Internal Medicine, Nippon Medical School
Kazuo DAN
The Department of Internal Medicine, Nippon Medical School
Ichiji WAKABAYASHI
The Department of Internal Medicine, Nippon Medical School

Keywords: syndrome of inappropriate secretion of antidiuretic hormone, hyponatremia

JOURNAL FREE ACCESS

1997 Volume 36 Issue 11 Pages 819-821

DOI https://doi.org/10.2169/internalmedicine.36.819

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Abstract

A 57-year-old female was admitted to our hospital because of Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). On admission, disturbance of consciousness and hyponatremia were recognized. The patient's endocrinological data showed low levels of adrenocorticotropic hormone (ACTH) (less than 5 pg/ml) and cortisol (5.9 μg/dl). Other anterior pituitary hormones were normal. Plasma ACTH and cortisol did not respond to the corticotropin releasing factor (CRF) test. A diagnosis of isolated ACTH deficiency was made. This is a rare case of isolated ACTH deficiency complicated with hematological malignancies.
(Internal Medicine 36: 819-821, 1997)

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