Hepatitis B Virus Carrier Status Linked to Autoimmune Hepatitis

Chisa MURAKAMI; Keisuke HINO; Muneko OKAZAKI; Kaori FUJII; Michiari OKUDA; Hiroshi HANADA; Takahiro YAMASAKI; Kiwamu OKITA

doi:10.2169/internalmedicine.35.468

Chisa MURAKAMI, Keisuke HINO, Muneko OKAZAKI, Kaori FUJII, Michiari OKUDA, Hiroshi HANADA, Takahiro YAMASAKI, Kiwamu OKITA

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Chisa MURAKAMI
The First Department of Internal Medicine, Yamaguchi University, School of Medicine
Keisuke HINO
The First Department of Internal Medicine, Yamaguchi University, School of Medicine
Muneko OKAZAKI
The First Department of Internal Medicine, Yamaguchi University, School of Medicine
Kaori FUJII
The First Department of Internal Medicine, Yamaguchi University, School of Medicine
Michiari OKUDA
The First Department of Internal Medicine, Yamaguchi University, School of Medicine
Hiroshi HANADA
The First Department of Internal Medicine, Yamaguchi University, School of Medicine
Takahiro YAMASAKI
The First Department of Internal Medicine, Yamaguchi University, School of Medicine
Kiwamu OKITA
The First Department of Internal Medicine, Yamaguchi University, School of Medicine

Keywords: autoimmmunity, hepatitis C virus, steroid therapy

JOURNAL FREE ACCESS

1996 Volume 35 Issue 6 Pages 468-471

DOI https://doi.org/10.2169/internalmedicine.35.468

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Abstract

We describe a hepatitis B virus carrier who satisfied the criteria of autoimmune hepatitis proposed by the International Autoimmune Hepatitis Group. A 43-year-old Japanese female showed human leukocyte antigen typing including DR4 in addition to hypergammaglobulinemia, presence of autoantibodies, and liver histology suggestive of autoimmune hepatitis. Moreover, the predominant presence of hepatitis B core antigen in nuclei rather than in cytoplasm of hepatocytes suggested less of a possibility of liver cell damage related to hepatitis B virus infection. She completely responded to immunosuppressive therapy and no clinical or biochemical relapse has been recognized to date.
(Internal Medicine 35: 468-471, 1996)

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