Multiple Myeloma Complicated by Congestive Heart Failure Following First Administration of Recombinant α-Interferon

Toshitaka KOBAYASHI; Yuji SATO; Yuichi HASEGAWA; Toshiro NAGASAWA; Yasuhiro YODA; Tsukasa ABE

doi:10.2169/internalmedicine.31.936

Toshitaka KOBAYASHI, Yuji SATO, Yuichi HASEGAWA, Toshiro NAGASAWA, Yasuhiro YODA, Tsukasa ABE

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Keywords: adverse reactions, abnormal electro-cardiogram

JOURNAL FREE ACCESS

1992 Volume 31 Issue 7 Pages 936-940

DOI https://doi.org/10.2169/internalmedicine.31.936

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Abstract

A 59-year-old female was admitted to Tsukuba University Hospital and diagnosed as IgA-λ multiple myeloma (stage IIIA). No cardiovascular disorder with the exception of minor ischemic changes in ECG was revealed before treatment. Recombinant human α-interferon (IFN) at a dose of 3 million units combined with melphalan and prednisolone was administrated. Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF). Treatment with diuretics and catecholamine products showed almost complete recovery from CHF in 3 weeks. An adverse reaction to IFN was strongly suspected as the cause of CHF.
(Internal Medicine 31 : 936-940, 1992)

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