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Nail Cosmetics

Allergies and Irritations

  • Review Article
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American Journal of Clinical Dermatology Aims and scope Submit manuscript

Abstract

Recent precise figures are not available for the number of adverse reactions related to the use of nail care products. Reactions to nail cosmetic procedures may be divided into reactions at the site of application to the nail itself and ectopic reactions, when the hand transfers a small amount of nail cosmetic to other areas of the skin.

Fingernail coatings encompass two types: (i) coatings that harden upon evaporation (nail enamel, base coat, top coat); and (ii) coatings that polymerize (sculptured nails, light-curing gels, preformed artificial nails, nail mending and nail wrapping).

The test battery enables us to distinguish allergic reactions from irritant reactions. Interestingly, some reactions, such as distant allergic contact dermatitis, are more frequent with nail enamel than with coatings that polymerize. On the other hand, the latter are greater offenders in the nail area.

Nail hardeners may just be modified nail enamels containing nylon fibers, acrylate resin and hydrolyzed proteins. Others may contain up to 5% formaldehyde tissue fixative (which can have adverse effects on the nail), but are designed in the US to be applied only to the free edge of the nail while the skin is shielded. Caution is necessary in interpreting formaldehyde patch testing reactions.

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Notes

  1. Use of tradenames is for product identification purposes only and does not imply endorsement.

References

  1. Calnan C.D., Sarkany J. Studies in contact dermatitis: nail varnish. Trans St John’s Hosp Dermatol Soc 1958; 40: 1–11

    Google Scholar 

  2. Tosti A., Guerra L., Vincenzi C., et al. Contact sensitization caused by toluene sulfonamide-formaldehyde resin in women who use nail cosmetics. Am J Contact Dermatitis 1993; 4: 150–153

    Google Scholar 

  3. Baran R. Pathology induced by the application of cosmetics to the nail. In: Frost P., Horwitz S.N., editors. Principle of cosmetics for the dermatologist. St Louis: Mosby, 1982: 181–184

    Google Scholar 

  4. Baran R., De Berker D., Dawber R. Manuel of nail disease and surgery. Oxford: Blackwell Science, 1997: 51

    Google Scholar 

  5. Kanerva L., Lauerma A., Estlander T., et al. Occupational allergic contact dermatitis caused by photobonded sculptured nails and a review of (meth)acrylates in nail cosmetics. Am J Contact Dermat 1996; 7: 109–115

    Article  PubMed  CAS  Google Scholar 

  6. Baran R. Nail beauty therapy: an attractive enhancement or a potential hazard? J Cosmet Dermatol 2002; 1: 24–29

    Article  PubMed  Google Scholar 

  7. Baran R., Schoon D. Cosmetology of normal nails. In: Baran R., Maibach H.I., editors. Textbook of cosmetic dermatology. London: Martin Dunitz, 1998

    Google Scholar 

  8. Schoon D., Baran R. Cosmetics for nails. In: Barel A.O., Paye M., Maibach H.I., editors. Handbook of cosmetic science and technology. New York: Marcel Dekker, 2001: 685–687

    Google Scholar 

  9. Staines K.S., Felix D.H., Forsyth A. Desquamative gingivitis, sole manifestation of tosylamide/formaldehyde resin allergy. Contact Dermatitis 1998; 39: 90

    Article  PubMed  CAS  Google Scholar 

  10. Dooms-Goossens E. Contact dermatitis caused by airborn agents. J Am Acad Dermatol 1986; 15: 1–18

    Article  PubMed  CAS  Google Scholar 

  11. Tosti A., Guerra L., Vincenzi C., et al. Contract sensitization caused by toluene sulfonamide-formaldehyde resin in women who use nail cosmetics. Am J Contact Dermat 1993; 3: 150–153

    Google Scholar 

  12. Anonide A., Usiglio D., Pestarino A., et al. Frequency of positivity to nail varnish allergens: study of eighty women. G Ital Dermatol Venereol 1995; 130: 13–16

    Google Scholar 

  13. Fisher A.A. Contact dermatitis. Philadelphia: Lea & Febiger, 1986

    Google Scholar 

  14. Hausen B.M., Milbrodt M., Koenig W.A. The allergens of nail polish: allergenic constituents of common nail polish and toluenesulfonamide-formaldehyde resin. Contact Dermatitis 1995; 33: 157–164

    Article  PubMed  CAS  Google Scholar 

  15. Castelain M., Veyrat S., Laine G., et al. Contact dermatitis from nitrocellulose in a nail varnish. Contact Dermatitis 1997; 36: 266–267

    Article  PubMed  CAS  Google Scholar 

  16. Stritzler C. Dermatitis of the face caused by guanine in pearly nail lacquer. Arch Dermatol 1958; 78: 252–253

    Article  CAS  Google Scholar 

  17. Kanerva L., Lauerma A., Jolanki R., et al. Methyl acrylate: a new sensitizer in nail lacquer. Contact Dermatitis 1995; 33: 203–204

    Article  PubMed  CAS  Google Scholar 

  18. Bonu G., Zina G. Reazione da contatto morfologicamente inconsueta. Minerva Dermatol 1959; 33: 507–509

    Google Scholar 

  19. Liden C., Berg M., Färm G., et al. Nail varnish allergy with far-reaching consequences. Br J Dermatol 1993; 123: 57–62

    Article  Google Scholar 

  20. Samman P.D. Nail disorders caused by external influences. J Soc Cosmet Chem 1977; 28: 351–356

    Google Scholar 

  21. Brauer E., Baran R. Cosmetics: the care and adornment of the nail. In: Baran R., Dawber R.P.R., De Berker D., et al. Diseases of the nails and their management. Oxford: Blackwell, 2001: 358–369

    Chapter  Google Scholar 

  22. Kechijian P. Nail polish removers: are they harmful? Semin Dermatol 1991; 10: 26–28

    PubMed  CAS  Google Scholar 

  23. Engasser P.G. Nail cosmetics.In: Scher R.K., Daniel C.R., editors. Nails-therapydiagnosis-surgery. Philadelphia: WB Saunders, 1997: 276–281

    Google Scholar 

  24. Fisher A.A., Franks A., Glick H. Allergic sensitization of the skin and nails to acrylic plastic nails. J Allergy 1957; 28: 84–89

    Article  PubMed  CAS  Google Scholar 

  25. Marks J.G., Bishop M.E., Willis W.F. Allergic contact dermatitis to sculptured nails. Arch Dermatol 1979; 115: 100

    Article  PubMed  Google Scholar 

  26. Fitzgerald D.A., English J.S.C. Widespread contact dermatitis from sculptured nails. Contact Dermatitis 1994; 30: 118

    Article  PubMed  CAS  Google Scholar 

  27. Fisher A.A. Permanent loss of fingernails due to allergic reaction to an acrylic nail preparation: a sixteen-year follow-up study. Cutis 1989; 43: 404–407

    PubMed  CAS  Google Scholar 

  28. Freeman S., Lee M.S., Gudmundsen K. Adverse contact reactions to sculptured acrylic nails: 4 cases-reports and a literature review. Contact Dermatitis 1995; 33: 381–385

    Article  PubMed  CAS  Google Scholar 

  29. Kanerva L., Mikola H., Enricks-Eckerman M.L., et al. Fingertip paresthesia and occupational allergic contact dermatitis caused by acrylics in a dental nurse. Contact Dermatitis 1998; 38: 114–116

    Article  PubMed  CAS  Google Scholar 

  30. Baran R., Schibli H. Permanent paresthesia to sculptured nails: a distressing problem. Dermatol Clin 1990; 8: 138–141

    Google Scholar 

  31. Fisher A.A., Baran R. Adverse reactions to acrylate sculptured nails with particular reference to prolonged paresthesia. Am J Contact Dermat 1991; 2: 38–42

    Google Scholar 

  32. Koppula S.V., Fellman J.H., Storrs F.J. Screening allergens for acrylate dermatitis associated with artificial nails. Am J Contact Dermat 1995; 6: 78–85

    Article  Google Scholar 

  33. Kanerva L., Estlander T., Jolanki R., et al. Statistics on allergic patch test reactions caused by acrylate compounds, including data on ethyl methacrylate. Am J Contact Dermat 1995; 6: 75–77

    Article  Google Scholar 

  34. Guin J.D. Eyelid dermatitis from benzophenone used in nail enhancement. Contact Dermatitis 2000; 43: 308–309

    PubMed  CAS  Google Scholar 

  35. Schubert H.J., Lindner K., Prater E. Kontaktallergie in Nagestudio. Z Hautkr 1992; 67: 1067–1069

    Google Scholar 

  36. Halgmüller T., Hemmer W., Kusak I., et al. Loss of fingernails due to persisting allergic contact dermatitis in an artificial nail designer [abstract]. J Allergy Clin Immunol 1995; 95: 250

    Google Scholar 

  37. Hemmer W., Focke M., Wantke F., et al. Allergic contact dermatitis to artificial fingernails prepared from UV light-cured acrylates. J Am Acad Dermatol 1996; 35: 377–380

    Article  PubMed  CAS  Google Scholar 

  38. Calnan C.D. Cyanoacrylate dermatitis. Contact Dermatitis 1970; 5: 165–166

    Article  Google Scholar 

  39. Fitzgerald D.A., Bhaggoe R., English J.S., et al. Contact sensitivity to cyanoacrylate nail-adhesive with dermatitis at remote sites. Contact Dermatitis 1995; 32: 175–176

    Article  PubMed  CAS  Google Scholar 

  40. Kanerva L., Estlander T. Allergic onycholysis and paronychia caused by cyanoacrylate nail glue, but not by photobonded methacrylate. Eur J Dermatol 2000; 10: 223–225

    PubMed  CAS  Google Scholar 

  41. Guin J.D., Baas K., Nelson-Adersokan P. Contact sensitization to cyanoacrylate adhesive as a cause of severe onycho-dystrophy. Int J Dermatol 1998; 37: 31–36

    Article  PubMed  CAS  Google Scholar 

  42. Higashi N., Kume A., Taniguchi T., et al. Two cases of allergic contact dermatitis from nail cosmetics. Environ Dermatol 2000; 7: 79–83

    Google Scholar 

  43. Shelley E.D., Shelley W.B. Nail dystrophy and periungual dermatitis due to cyanoacrylate glue sensitivity. J Am Acad Dermatol 1988; 19: 574–575

    Article  PubMed  CAS  Google Scholar 

  44. Burrows D., Rycroft R.J.G. Contact dermatitis from PTBP and tricresyl ethyl phthalate in a plastic resin. Contact Dermatitis 1981; 7: 336–337

    Article  PubMed  CAS  Google Scholar 

  45. Shelley E.D., Shelley W.V. Chronic dermatitis simulating small-plaque parapsoriasis due to cyanoacrylate adhesive used on fingernails. JAMA 1984; 252: 2455–2456

    Article  PubMed  CAS  Google Scholar 

  46. Pigatto P.D., Giacchetti A., Altomare G.F. Unusual sensitization to cyanoacrylate ester. Contact Dermatitis 1986; 14: 193

    Article  PubMed  CAS  Google Scholar 

  47. Lazar P. Reactions to nail hardeners. Arch Dermatol 1966; 94: 446–448

    Article  PubMed  CAS  Google Scholar 

  48. Mitchell J.C. Non-inflammatory onycholysis from formaldehyde-containing nail hardener. Contact Dermatitis 1981; 7: 173

    Article  PubMed  CAS  Google Scholar 

  49. Daly B.M., Johnson M. Pterygium inversum inguis due to nail fortifier. Contact Dermatitis 1986; 15: 256–257

    Article  PubMed  CAS  Google Scholar 

  50. Hüldin D.H. Hemorrhages of the lips secondary to nail hardeners. Cutis 1968; 4: 708

    Google Scholar 

Download references

Acknowledgments

The authors have provided no information on sources of funding or on conflicts of interest directly relevant to the content of this review.

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  1. Nail Disease Center, 42, rue des Serbes, Cannes, 06400, France

    Robert Baran

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  1. Robert Baran
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Correspondence to Robert Baran.

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Baran, R. Nail Cosmetics. Am J Clin Dermatol 3, 547–555 (2002). https://doi.org/10.2165/00128071-200203080-00005

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