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Role of Adenosine Receptors in the Treatment of Asthma and Chronic Obstructive Pulmonary Disease

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Abstract

Adenosine is a naturally occurring purine nucleoside with a ubiquitous presence in human tissue, where it plays a key role in many biological processes such as energy generation and protein metabolism. It has been shown that adenosine induces bronchoconstriction in asthmatic and chronic obstructive pulmonary disease (COPD) patients, but not in normal airways. Four different G-protein-coupled adenosine receptors have been described, namely adenosine A1, A2A, A2B and A3 receptors. The main mechanism of adenosine-induced bronchoconstriction appears to involve the release of inflammatory mediators from mast cells via activation of the A2B receptor. However, adenosine can also act on A1, A2A and A3 receptors. In recent years there has been an increasing interest in the role of adenosine receptors in asthma and COPD, since it is now clear that they play an important role in the pathophysiology of asthma and COPD. Adenosine receptors are involved in the production and release of a variety of mediators from inflammatory and structural cells. A therapeutic potential for adenosine receptor modulation has even been anticipated. This review focuses on the role of adenosine and adenosine receptors in the treatment of asthma and COPD.

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No sources of funding were used to assist in the preparation of this review. The authors have no conflicts of interest that are directly relevant to the content of this review.

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  1. Department of Pulmonary Diseases, University Hospital Groningen, Hanzeplein 1, Groningen, 9700 RB, The Netherlands

    Maarten van den Berge &  Dirkje S. Postma

  2. Department of Pathology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

    Machteld N. Hylkema & Mieke Versluis

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  1. Maarten van den Berge
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  2. Machteld N. Hylkema
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van den Berge, M., Hylkema, M.N., Versluis, M. et al. Role of Adenosine Receptors in the Treatment of Asthma and Chronic Obstructive Pulmonary Disease. Drugs R D 8, 13–23 (2007). https://doi.org/10.2165/00126839-200708010-00002

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