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Emerging Therapies for Multiple Myeloma

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American Journal of Cancer

Abstract

Multiple myeloma (MM) is a malignancy of plasma cells within the bone marrow characterized by bone loss, renal disease, and immunodeficiency. Recent advances in the understanding of MM pathogenesis have improved established conventional cytotoxic therapy as well as transplantation regimens. Despite these advances, median overall survival is only 3–5 years. Therefore new therapies are urgently needed. Besides thalidomide, whose antimyeloma activity has only recently been defined, a plethora of novel agents, including the thalidomide-derived immunomodulatory drugs and bortezomib, have been identified to directly target the tumor cell or its microenvironment, and thereby inhibit MM cell growth and survival, and to overcome drug resistance. After validation of their preclinical anti-MM activity, several clinical trials are now ongoing to test the efficacy of these novel therapeutics, administered alone or in combination with conventional or other novel therapeutics and bone marrow transplantation. This article reviews the development of MM therapy, from its initial description approximately 150 years ago to the novel therapy regimens of recent years, highlighting that MM may soon become a chronic disease.

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Acknowledgments

This work was supported by grants from the National Institutes of Health (RO 50947, PO-1 78378, SPORE P50 CA10070) and the Doris Duke Distinguished Clinical Research Scientist Award (to K.C. Anderson). P.G. Richardson has received honoraria from Celgene and Millenium. The authors have no potential conflicts of interest directly relevant to the contents of this article.

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Podar, K., Hideshima, T., Tai, YT. et al. Emerging Therapies for Multiple Myeloma. Am J Cancer 5, 141–153 (2006). https://doi.org/10.2165/00024669-200605030-00001

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