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Lymphokines

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References

  • Altmann A, Katz DH. The biology of monoclonal lymphokines secreted by T cell lines and hybridomas. Advances in Immunology 33: 73–166, 1982

    Article  Google Scholar 

  • Beutler B, Greenwald D, Hulmes JD, Chang M, Pan YCE, et al. Identity of tumour necrosis factor and the macrophage-secreted factor cachetin. Nature 316: 552–555, 1985a

    Article  PubMed  CAS  Google Scholar 

  • Beutler B, Milsark W, Cerami A. Passive immunization against cachectin/tumor necrosis factor (TNF) protects mice from the lethal effect of endotoxin. Science 229: 869–871, 1985b

    Article  PubMed  CAS  Google Scholar 

  • Brooks CG, Holscher M, Urdal D. Natural killer activity in cloned cytotoxic T lymphocytes: regulation by interleukin 2, interferon, and specific antigen. Journal of Immunology 135: 1145–1152, 1985

    CAS  Google Scholar 

  • Came PE, Carter WA. Interferon: its application and future as an anti-neoplastic agent. In Ottenbrie RM & Butler GB (Eds) Drugs and the pharmaceutical sciences, Vol. 24, Marcel Dekker, New York, 1983

    Google Scholar 

  • Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, et al. An endotoxin-induced serum factor that causes necrosis of tumors. Proceedings of the National Academy of Sciences (USA) 72: 3666–3673, 1975

    Article  CAS  Google Scholar 

  • Dempsey RA, Dinarello CA, Meir JW, Rosenwasser LJ, Allegretta M, et al. The differential effects of human leukocytic pyrogen/lymphocyte activating factor, T cell growth factor, and interferon on human natural killer activity. Journal of Immunology 129: 2504–2511, 1982

    CAS  Google Scholar 

  • Dinarello CA. Interleukin 1. Reviews of Infectious Diseases 6: 51–955, 1984

    Article  PubMed  CAS  Google Scholar 

  • Donahue RE, Wang EA, Stone DK, Kamen R, Wong GC, et al. Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF. Nature 321: 872–875, 1986

    Article  PubMed  CAS  Google Scholar 

  • Farrar JJ, Benjamin WR, Hilfiker ML, Howard M, Farrar WL, et al. The biochemistry, biology, and role of interleukin 2 in the induction of cytotoxic T cell and antibody forming B cell responses. Immunology 63: 129–209, 1982

    CAS  Google Scholar 

  • Gery I, Gershon RK, Waksman BH. Potentiation of the T-lymphocyte response to mitogens. I. The responding cell. Journal of Experimental Medicine 136: 128–142, 1972

    Article  PubMed  CAS  Google Scholar 

  • Goeddel DV, Yelverton E, Ulrich A, Heyneker HL, Miozzari CF, et al. Human leukocyte interferon produced by E. coli is biologically active. Nature 287: 411–416, 1980

    Article  PubMed  CAS  Google Scholar 

  • Gowen M, Wood DD, Ihrie EJ, McGuire MKB, Russel RG. An interleukin-1-like factor stimulates bone resorption in vitro. Nature 306: 378–380, 1983

    Article  PubMed  CAS  Google Scholar 

  • Gray PW, Pennica D, Yelverton E, Najarian R, Simonsen CC, et al. Expression of human interferon cDNA in E. coli and monkey cells. Nature 295: 503–508, 1982

    Article  PubMed  CAS  Google Scholar 

  • Grimm EA, Mazumder A, Zhang HZ, Rosenberg SA. Lymphokine-activated killer cell phenomenon. Lysis of natural-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes. Journal of Experimental Medicine 155: 1823–1841, 1982

    Article  PubMed  CAS  Google Scholar 

  • Henney CS, Kuribayashi K, Kern DE, Gillis S. Interleukin-2 augments natural killer cell activity. Nature 291: 225–338, 1981

    Article  Google Scholar 

  • Herrmann F, Cannistra SA, Levine H, Griffin JD. Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells. Journal of Experimental Medicine 162: 1111–1116, 1985

    Article  PubMed  CAS  Google Scholar 

  • Howard M, Farrar J, Hilfiker M, Johnson B, Takatsu K, et al. Identification of a T cell-derived B cell growth factor distinct from interleukin 2. Journal of Experimental Medicine 155: 914–921, 1982

    Article  PubMed  CAS  Google Scholar 

  • Lane HC, Siegel JP, Rook AH, Masur H, Gelmann EP, et al. Use of interleukin-2 in patients with acquired immunodeficiency syndrome. Journal of Biological Response Modifiers 3: 512–516, 1984

    PubMed  CAS  Google Scholar 

  • Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, et al. A monoclonal antibody that appears to recognise the receptor for human T-cell growth factor, partial characterization of the receptor. Nature 300: 207, 1982

    Article  Google Scholar 

  • March C, Mosley B, Larseh A, et al. Cloning, sequence and expression of two distinct human interleukin 1 complementary DNAs. Nature 315: 641–648, 1985

    Article  PubMed  CAS  Google Scholar 

  • Mazumder A, Rosenberg SA. Successful immunotherapy of killer-resistant established melanoma metastases by the intravenous adoptive transfer of syngeneic lymphocytes activated in vitro by interleukin 2. Journal of Experimental Medicine 159: 495–507, 1984

    Article  PubMed  CAS  Google Scholar 

  • Mizel SB, Farrar JJ. Revised nomenclature for antigen-nonspecific T-cell proliferation and helper factors. Cellular Immunology 48: 433–436, 1979

    Article  PubMed  CAS  Google Scholar 

  • Moore RN, Hoffeld JT, Farrar JJ, Mergenhagen SE, Oppenheim JJ, et al. Role of colony-stimulating factors as primary regulators of macrophage functions. Lymphokines 3: 119–148,1981

    CAS  Google Scholar 

  • Morgan DA, Ruscetti FW, Gallo R. Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193: 1007–1008, 1976

    Article  PubMed  CAS  Google Scholar 

  • Mule JJ, Shu S, Rosenberg SA. The anti-tumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo. Journal of Immunology 135: 646–652, 1985

    CAS  Google Scholar 

  • Murphy PA, Simon PL, Willoughby WF. Endogenous pyrogens made by rabbit peritoneal exudate cells are identical with lymphocyte activating factors made by rabbit alveolar macrophages. Journal of Immunology 124: 2498–2503, 1980

    CAS  Google Scholar 

  • Oppenheim JJ, Kovacs EJ, Matsushima K, Durum SK. There is more than one interleukin 1. Immunology Today 7: 45–56, 1986

    Article  CAS  Google Scholar 

  • Ortaldo JR, Mason AT, Gerard JP, Henderson LE, Farrar W, et al. Effects of natural and recombinant IL 2 on regulation of IFN-gamma production and natural killer activity: lack of involvement of the TAC antigen for these immunoregulatory effects. Journal of Immunology 133: 779–783, 1984

    CAS  Google Scholar 

  • Quesada JR, Reuben J, Manning JT, et al. Induction of remission in hairy cell leukemia with alpha interferon. New England Journal of Medicine 310: 15–18, 1984

    Article  PubMed  CAS  Google Scholar 

  • Rocklin RE, Benaltzen K, Greineder D. Mediators of immunity: lymphokines and monotones. Advances in Immunology 29: 55–136, 1980

    Article  PubMed  CAS  Google Scholar 

  • Rook AH, Masur H, Lane HC, Frederick WR, Kasahara T, et al. Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome. Journal of Clinical Investigation 72: 398–403, 1983

    Article  PubMed  CAS  Google Scholar 

  • Rosenberg SA, Lotze MT. Cancer immunotherapy using interleukin-2 and interleukin-2-activated lymphocytes. Annual Review of Immunology 3: 681–709, 1986

    Article  Google Scholar 

  • Rouse BT, Miller LS, Turtinen L, Moore RN. Augmentation of immunity to herpes simplex virus by in vivo administration of interleukin 2. Journal of Immunology 134: 926–930, 1985

    CAS  Google Scholar 

  • Siegel JP, Lane HC, Stocks NI, Quinnan GV, Fauci A. Pharmacokinetics of lymphocyte-derived and recombinant DNA-derived interleukin-2 after intravenous administration to patients with the acquired immunodeficiency syndrome. Journal of Biological Response Modifiers 4: 596–601, 1985

    PubMed  CAS  Google Scholar 

  • Siegel JP, Rook AH, Djeu JY, Quinnan GV. Interleukin 2 therapy in infectious diseases: rationale and prospects. Infection 12: 298–302,1984

    Article  PubMed  CAS  Google Scholar 

  • Smith KA. T cell growth factor. Immunological Reviews 51: 337–352, 1980

    Article  PubMed  CAS  Google Scholar 

  • Smith KA, Gilbride KT, Fabata MF. Lymphocyte activating factor promotes T cell growth factor production by cloned murine lymphoma cells. Nature 287: 353–355, 1980

    Article  Google Scholar 

  • Sonnenfeld G, Mandel A, Merigan TC. Time and dosage dependence of immunoenhancement by murine type II interferon preparations. Cellular Immunology 40: 285–293, 1978

    Article  PubMed  CAS  Google Scholar 

  • Spiegel RJ. Clinical trials in non-hematologic malignancies. In Kisner DL & Smyth JF (Eds) Interferon-alpha-2: preclinical and clinical evaluation, Martin Nijhoff Publishers, Boston, 1985

    Google Scholar 

  • Stanley ER, Jubinsky PT. Factors affecting the growth and differentiation of haemopoietic cells in culture. Clinics in Haematology 13: 329–348, 1984

    PubMed  CAS  Google Scholar 

  • Stewart WE. The interferon system, Springer Verlag, New York, 1981

    Book  Google Scholar 

  • Svedersky LP, Shepard HM, Spencer SA, Shalaby MR, Palladino MA. Augmentation of human natural cell-mediated cytotoxicity by recombinant human interleukin 2. Journal of Immunology 126: 2321–2327, 1981

    Google Scholar 

  • Taniguchi T, Matsui H, Fujita T, Takaoka C, Kashima N, et al. Structure and expression of a cloned cDNA for human interleukin 2. Nature 302: 305–310, 1983

    Article  PubMed  CAS  Google Scholar 

  • Taniguchi T, Sakai M, Fuji-Kuriyama Y, Muramatsu M, Kobayashi S, et al. Construction and identification of a bacterial plasmid containing the human fibroblast interferon gene sequence. Proceedings of the Japanese Academy 55B: 464–469, 1979

    Article  Google Scholar 

  • Terry WD, Rosenberg SA. Immunotherapy of human cancer, Elsevier North-Holland, New York, 1982

    Google Scholar 

  • Torti FM, Dieckmann B, Beutler B, Cerami A, Ringold GM. A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia. Science 229: 867–869, 1985

    Article  PubMed  CAS  Google Scholar 

  • Trinchieri G, Perussia B. Immune Interferon: a pleiotropic lymphokine with multiple effects. Immunology Today 6: 133–138, 1985

    Article  Google Scholar 

  • Vilcek J, Gray PW, Rinderknecht E, Sevestopoulos CG. Interferon: a lymphokine for all seasons. Lymphokines 11: 1–32, 1985

    CAS  Google Scholar 

  • Week PK, Cam PE. Comparative biologic activities of human interferons. In Cam PE & Carter WA (Eds) Comparative interferons and their applications, Springer Verlag, New York, 1984

    Google Scholar 

  • Williamson B, Carswell EA, Rubin BY, Prendergast JS, Old LJ. Human TNF produced by human B cell lines: synergistic cytotoxin interaction with human interferon. Proceedings of the National Academy of Sciences 80: 5397–5401, 1983

    Article  CAS  Google Scholar 

  • Wong GC, Witek JA, Temple PA, Wilkens KM, Leary AC, et al. Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins. Science 228: 810–815, 1985

    Article  PubMed  CAS  Google Scholar 

  • Zoon KC, Hu R, Zur Nedden D, Gerrard TL, Enterline JC, et al. Further studies on the purification and partial characterization of human lymphoblastoid interferon alphas. In Stewart WE & Schellekens H (Eds) The biology of the interferon system 1985, Elsevier, Amsterdam, 1986

    Google Scholar 

  • Zubler RH, Lowenthal JW, Erard F, Hashimoto N, Devos R, et al. Activated B cells express receptors for, and proliferate in response to, pure interleukin 2. Journal of Experimental Medicine 160: 1170–1183, 1984

    Article  PubMed  CAS  Google Scholar 

  • Zur Nedden D, Gerrard TL, Zoon KC. Activation of human monocyte tumorcidal activity by specifies of human lymphoblastoid interferon alpha. Abstract no. 111–56, ISIR-TNO meeting on the interferon system, Espoo, Finland, 1986

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Horohov, D.W., Siegel, J.P. Lymphokines. Drugs 33, 289–295 (1987). https://doi.org/10.2165/00003495-198733040-00001

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