Summary
The in vitro activity of temocillin, cefotaxime, aztreonam and ceftazidime was tested against selected cefotaxime-resistant isolates (43 Enterobacter species, 37 Serratia marcescens, 16 Morganella morganii, 8 Klebsiella species) and cefotaxime-susceptible strains of the same species. Cross-resistance with a high degree of correlation was observed between cefotaxime and aztreonam or ceftazidime, but not between cefotaxime and temocillin.
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Croxton, F.E.: Tests for correlation coefficients; in Croxton (Ed) Elementary Statistics with Applications in Medicine and the Biological Sciences, pp.312–318 (Dover Publications Inc., New York 1959).
Jules, K. and Neu, H.: Antibacterial activity and β-lactamase stability of temocillin. Antimicrobial Agents and Chemotherapy 22: 453–460 (1982).
Lagast, H. and Klastersky, J.: Comparative in vitro activities of temocillin and cefazolin against Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy 22: 330–331 (1982).
Slocombe, B.; Basker, M.J.; Bentley, P.H.; Clayton, J.P.; Cole, M.; Comber, K.R.; Dixon, R.A.; Edmondson, R.A.; Jackson, D.; Merrikin, D.J. and Sutherland, R.: BRL 17421: A novel β-lactam antibiotic highly resistant to β-lactamase; giving high and prolonged serum levels in humans. Antimicrobial Agents and Chemotherapy 20: 38–46 (1981).
Van Landuyt, H.W.; Pyckavet, M.; Lambert, A.M. and Boelaert, J.: In vitro activity of temocillin (BRL 17421), a novel β-lactam antibiotic. Antimicrobial Agents and Chemotherapy 22: 535–540 (1982).
Verbist, L.: In vitro activity of temocillin (BRL 17421), a novel β-lactamase stable penicillin. Antimicrobial Agents and Chemotherapy 22: 157–161 (1982).
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Verbist, L. Temocillin Sensitivity of Enterobacteriaceae Species Resistant to Cefotaxime. Drugs 29 (Suppl 5), 38–42 (1985). https://doi.org/10.2165/00003495-198500295-00009
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DOI: https://doi.org/10.2165/00003495-198500295-00009