Summary
The antibacterial activity of temocillin, a novel β-lactam antibiotic, was tested against 796 clinical isolates. We also conducted a comparative study against 8 other antibiotics. Temocillin exhibited good activity against Gram-negative organisms including Escherichia coli, and the genera Proteus, Enterobacter, Serratia, Klebsiella, Citrobacter, Providencia, Salmonella, Shigella and Haemophilus: 98% of the strains were inhibited by concentrations ❽ 16 mg/L. The results of this in vitro study and temocillin’s favourable pharmacokinetic properties suggest that temocillin is a very promising penicillin for the treatment of hospital infections caused by Gram-negative organisms.
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References
Bolivar, R.; Weaver, S.S. and Bodey, G.P.: Comparative in vitro study of temocillin (BRL 17421), a new penicillin. Antimicrobial Agents and Chemotherapy 21: 641–645 (1982).
Clarke, A.M. and Zemcov, S.J.V.: Comparative in vitro activity of temocillin (BRL 17421), a new penicillin. Journal of Antimicrobial Chemotherapy 11: 319–324 (1983).
Fainstain, V.; Weaver, S.S. and Bodey, G.P.: Comparative in vitro study of SQ 26776. Antimicrobial Agents and Chemotherapy 21: 294–298 (1982).
Greenwood, D.; Cowlishaw, A. and Eley, A.: In vitro activity of temocillin, a new β-lactamase-stable penicillin active against Enterobacteriaceae. Antimicrobial Agents and Chemotherapy 22: 198–200 (1982).
Jules, K. and Neu, H.C.: Antibacterial activity and β-lactamase stability of temocillin. Antimicrobial Agents and Chemotherapy 22: 453–460 (1982).
Van Landuyt, H.W.; Pyckavet, M.; Lambert, A. and Boelaert, J.: In vitro activity of temocillin (BRL 17421), a novel β-lactam antibiotic. Antimicrobial Agents and Chemotherapy 22: 535–540 (1982).
Slocombe, B.; Basker, M.J.; Bentley, P.H.; Clayton, J.P.; Cole, M.; Comber, K.R.; Dixon, R.A.; Edmondson, R.A.; Jackson, D.; Merrikin, D.J. and Sutherland, R.: BRL 17421: A novel βlactam antibiotic highly resistant to β-lactamases, giving high and prolonged levels in humans. Antimicrobial Agents and Chemotherapy 20: 34–46 (1981).
Sykes, R.B.; Cimurusti, D.P.; Bonner, K.; Bush, K.; Floyd, D.M.; Georgopapadakou, N.H.; Koster, V.H. and Liv, W.C.: Monocyclic β-lactam antibiotics produced by bacteria. Nature (London) 291: 491–494 (1981).
Yogev, R.; Glogowski, W. and Connor, E.: Comparative in vitro and in vivo activity of temocillin (BRL 17421) and ampicillin against Haemophilus influenzae type b. Antimicrobial Agents and Chemotherapy 23: 182–184 (1983).
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Gobernado, M., Canton, E. Comparative In Vitro Activity of Temocillin. Drugs 29 (Suppl 5), 24–31 (1985). https://doi.org/10.2165/00003495-198500295-00007
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DOI: https://doi.org/10.2165/00003495-198500295-00007