References
Aberg G, Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds. Acta Pharmacologica el Toxicologica 31: 255–266, 1972
Ames MM, Frank SK. Stereochemical aspects of para-chloramphetamine metabolism. Biochemical Pharmacology 31: 5–9, 1982
Ariens EJ, Stereochemistry, a basis for sophisticated nonsense in pharmacokinelics and clinical pharmacology. European Journal of Clinical Pharmacology 26: 663–668, 1984
Ariens EJ, Wuis EW. Bias in pharmacokinetics and clinical pharmacology. Clinical Pharmacology and Therapeutics 424: 361–363, 1987
Armstrong DW, Optical isomer separation by liquid chromatography. Analytical Chemistry 592: 84A–91A, 1987
Bai SA, Walle UK, Wilson MJ, Walle T. Stereoselective binding of the (−)-enantiomer of Propranolol to plasma and extravascular binding sites in the dog. Drug Metabolism and Disposition 11: 394–395, 1983
Borgstrom L, Nyberg L, Jonsson S, Lindberg C, Paulson J, Pharmacokinetic evaluation in man of terbutaline given as separate enantiomers and as the racemate. British Journal of Clinical Pharmacology 27: 49–56, 1989
Boyd RA, Chin SK, Don-Pedro O, Williams RL, Giacomini KM, The pharmacokinetics of the enantiomers of atenolol. Clinical Pharmacology and Therapeutics 454: 403–410, 1989
Cahn RS, Ingold CK, Prelog V. The specification of asymmetric configuration in organic chemistry Experientia 12: 81–124, 1956
Cowan A, Geller EB, Adler MW, Classification of Opioids on the basis of change in seizure threshold in rats. Science 206: 465–467, 1979
Day RO, Williams KM, Graham GG, Lee EJD, Knihinicki RD, et al. Stereoselective disposition of ibuprofen enantiomers in synovial fluid. Clinical Pharmacology and Therapeutics 435: 480–487, 1989
Drayer DE, On the use of drugs administered as racemates. Clinical Pharmacology and Therapeutics 42: 364, 1987
Evans AM, Nation RL, Sansom LN, Bochner F, Somogyi AA, Stereoselectne drug disposition: potential for misinterpretation of drug disposition data. British Journal of Clinical Pharmacology 26: 771–780, 1988
Evans AM, Nation RL, Sansom LN, Bochner F, Somogyi AA, Stereoselective plasma protein binding of ibuprofen enantiomers. European Journal of Clinical Pharmacology 36: 283–290, 1989
Fitos I, Tegyey Z, Simonyi M, Sjoholm I, Larsson T, Lagercrantz C, Stereoselective binding of 3-acetoxy-. and 3-hydrox-1.4-benzodiazepine-2-ones to human serum albumin. Selective allosteric interaction with warfarin enantiomers. Biochemical Pharmacology 352: 263–269, 1986
Gal J, Stereoisomerism and drug nomenclature. Clinical Pharmacology and Therapeutics 443: 251–253, 1988
Giacomini KM, Nelson WL, Pershe RA, Valdivieso L, Turner-Tamiyasu K, et al. In vivo interaction of the enanliomers of disopyramide in human subjects. Journal of Pharmacokinetics and Biopharmaceutics 14: 335–356, 1986
Greig ME, Griffin RL. Antagonism of slow reacting substance in anaphylaxis SRS-A and other spasmogens on the guinea pig tracheal chain by hydratropic acids and their effects on anaphylaxis. Journal of Medicinal Chemistry 18: 112–116, 1975
Hendel J, Brodthagen H. Entero-hepatic cycling of methotrexate estimated by the use of the D-isomer as a reference marker. European Journal of Clinical Pharmacology 26: 103–107, 1984
Hsyu P-H, Giacomini KM. Stereoselective renal clearance of pindolol in humans. Journal of Clinical Investigation 76: 1720–1726, 1985
Karnes TH, Sarkar MA. Enantiomeric resolution of drug compounds by liquid chromatography. Pharmaceutical Research 44: 285–292, 1987
Kawashima K, Levy A, Speclor S. Stereospecific radioimmunoassay for Propranolol isomers. Journal of Pharmacology and Experimental Therapeutics 196: 517–523, 1976
Lee EJD, Williams KM, Graham GG, Day RO, Champion GD, Stereoselective disposition of ibuprofen enantiomers in man. British Journal of Clinical Pharmacology 19: 669–674, 1985
Lennard MS, Tucker GT, Silas JH, Freestone S, Ramsay LE, et al. Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquine metabolisers. Clinical Pharmacology and Therapeutics 34: 732–737, 1983
Lima JJ, Boudoulas H, Shields B. Stereoselective pharmacokinetics of disopyramide enantiomes in man. Drug Metabolism and Disposition 13: 572–577, 1985
Ofori-Adjei D, Ericsson O, Lindstrom B, Hermansson J, Adjepon-Yamoah, et al. Enantioselective analysis of chloroquine and desethylchloroquine after oral administration of racemic chloroquine. Therapeutic Drug Monitoring 8: 457–461, 1986
Pike MC, Snyderman R, Augmentation of human monocyte chemotactic response by levamisole. Nature 261: 136–137, 1976
Richards R, Tattersfield AE, Bronchial beta-adrenoeeptor blockade following eyedrops of timolol and its isomer L-714,465 in normal subjects. British Journal of Clinical Pharmacology 20: 459–462, 1985
Schilsky RL, Choi KE, Vokes EE, Guaspari A, Guanieri C, et al. Clinical pharmacology of the stereoisomers of leucovorin during repeated oral dosing. Cancer 63(Suppl. 6): 1018–1021, 1989
Simonyi M, Gal J, Testa B, Signs of the times: the need for a stereochemically informative generic name system. Trends in Pharmacological Sciences 10: 349–354, 1989
Testa B, Mechanisms of chiral recognition in xenobiotic metabolism and drug-receptor interactions. Chirality 1: 7–9, 1989
Testa B, Mayer JM. Stereoselective drug metabolism in its significance in drug research. Progress in Drug Research 32: 249–303, 1988
Tocco DJ, Hooke KF, Deluna FA, Duncan AEW. Stereospecific binding of timolol, a bela-adrenergic blocking agent. Drug Metabolism and Disposition 4: 323–329, 1976
Wade DN, Mearrick PT, Morris J. Active transport of L-dopa in the intestine. Nature 242: 463–465, 1973
Webb JG, Street JA, Bagwell EE, Walle T, Gaffney TE. Stereoselective secretion of atenolol from PC12 cells. Journal of Pharmacology and Experimental Therapeutics 2473: 958–964, 1988
White PF, Ham J, Way WL, Trevor AJ. Pharmacology of ketamine isomers in surgical patients. Anesthesiology 523: 231–239, 1980
Williams KM, Day R, Knihinicki R, Duffield A. The stereoselective uptake of ibuprofen enantiomers into adipose tissue. Biochemical Pharmacology 35: 3403–3405, 1986
Williams KM, Lee EJD. Importance of drug enantiomers in clinical pharmacology. Drugs 30: 333–354, 1985
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Lee, E.J.D., Williams, K.M. Chirality Clinical Pharmacokinetic and Pharmacodynamic Considerations. Clin Pharmacokinet 18, 339–345 (1990). https://doi.org/10.2165/00003088-199018050-00001
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DOI: https://doi.org/10.2165/00003088-199018050-00001