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Granulomatous Slack Skin Presenting as Acquired Ichthyosis and Muscle Masses

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Abstract

We describe a case of granulomatous slack skin in a 31-year-old woman with an unusual presentation of acquired ichthyosis and muscular masses involving four limbs over 3 years. Vesicles and ulcerative skin nodules first appeared only 3 months prior to diagnosis. The diagnosis was confirmed after sequential biopsies of muscle, skin lesions, and lymph nodes, together with molecular genetic studies. The patient responded poorly to various therapies, including thalidomide, and died of doxorubicin-related cardiomyopathy.

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Acknowledgments

No sources of funding were used to assist in the preparation of this case report. The authors have no conflicts of interest that are directly relevant to the content of this case report.

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Authors and Affiliations

  1. Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan

    Pa-Fan Hsiao

  2. Mackay Medicine, Nursing and Management College, Taipei, Taiwan

    Pa-Fan Hsiao

  3. Department of Pathology, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan

    Cheng-Hsiang Hsiao

  4. Department of Dermatology, National Taiwan University College of Medicine and National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan

    Tsen-Fang Tsai & Shiou-Hwa Jee

  5. Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan

    Ming Yao

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  1. Pa-Fan Hsiao
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  2. Cheng-Hsiang Hsiao
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  3. Tsen-Fang Tsai
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  4. Ming Yao
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  5. Shiou-Hwa Jee
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Correspondence to Tsen-Fang Tsai.

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Hsiao, PF., Hsiao, CH., Tsai, TF. et al. Granulomatous Slack Skin Presenting as Acquired Ichthyosis and Muscle Masses. Am J Clin Dermatol 10, 29–32 (2009). https://doi.org/10.2165/0128071-200910010-00004

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