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Overview of Allergic Mechanisms

Ebastine Has More Than an Antihistamine Effect

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Summary

Histamine antagonists together with topical steroids are the treatment of choice in allergic rhinitis. Many of these histamine antagonists exhibit effects in addition to blockade of the histamine receptor. In this study we have investigated the effects of ebastine and carebastine on the release of eicosanoids and cytokines from human dispersed polyp cells and the effect of these compounds on the release of inflammatory mediators into nasal lavage fluid after allergen challenge. Ebastine was shown to block the release of anti-IgE-induced prostaglandin D2 (PGD2) and leukotriene C4/D4 from human nasal polyp cells (IC30 values of 2.57 and 9.6 μmol/L, respectively) and to inhibit the release of cytokines. Carebastine inhibited the release of PGD2 (IC30 8.14 μmol/L) but had little effect on cytokine release. When patients underwent nasal provocation tests with allergen, ebastine significantly increased the mean number of pollen grains required to induce an allergic response. In addition, the drug inhibited the release of granulocyte-macrophage colony-stimulating factor but had no effect on any other mediators measured.

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Authors and Affiliations

  1. Service de Maladies Respiratoires, INSERM U454 Hôpital Arnaud de Villeneuve, 34295, Montpellier-Cedex 5, France

    Alison Campbell, François-Bernard Michel &  Jean Bousquet

  2. Rhône-Poulenc Rorer, SPECIA, Paris, France

    Clotilde Bremard-Oury

  3. Service d’ORL, Hôpital Saint Charles, Montpellier, France

    Louis Crampette

Authors
  1. Alison Campbell
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  2. François-Bernard Michel
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  3. Clotilde Bremard-Oury
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  4. Louis Crampette
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  5. Jean Bousquet
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Campbell, A., Michel, FB., Bremard-Oury, C. et al. Overview of Allergic Mechanisms. Drugs 52 (Suppl 1), 15–19 (1996). https://doi.org/10.2165/00003495-199600521-00005

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  • DOI: https://doi.org/10.2165/00003495-199600521-00005

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