Summary
Renin release from the kidneys is controlled by four major mechanisms — renal baroreceptors, the macula densa, the sympathetic nervous system and other humoral and ionic influences. Recently, the importance of the sympathetic nervous system in modulating renin release for a variety of stimuli has become apparent. The sympathetic adrenergic nerves act on a specific β-receptor to stimulate renin release from the kidney. Those antihypertensive drugs that inhibit adrenergic nerve transmission tend therefore to lower plasma renin. β-Adrenoreceptor blocking drugs also generally lower plasma renin by specific inhibition of renal renin release both in animals and humans. Diuretics and vasodilators in contrast elevate plasma renin levels.
Plasma renin levels in hypertensive patients are the net result of many diverse influences, and similarly in patients treated with antihypertensive drugs the plasma renin level often is the result of opposing influences. Plasma renin levels tend to return towards normal levels after treatment in hypertensive patients.
Plasma renin levels may offer a guide to a more rational basis for antihypertensive therapy in the future. However, the primary aim in treatment of the hypertensive patient should be to lower his blood pressure, independent of the effect of plasma renin levels.
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References
Aberg, H.: Plasma renin activity after the use of a new beta adrenergic blocking agent (ICI 66082). International Journal of Clinical Pharmacology 9: 98–100 (1974).
Alexandre, J.M.; Menard, J.; Chevillard, C. and Schmitt, H.: Increased plasma renin activity induced in rats by physostigmine and effects of alpha and beta receptor blocking drugs thereon. European Journal of Pharmacology 12: 127–131 (1970).
Anavekar, S.N.; Louis, W.J.; Morgan, T.O.; Doyle, A.E. and Johnston, C.I.: The relationship of plasma levels of pindolol in hypertensive patients to effects on blood pressure, plasma renin and plasma noradrenaline levels. Qinical and Experimental Pharmacology and Physiology 2: 203–212(1975).
Assaykeen, T.A.: Control of renin secretion; in Assaykeen (Ed.). Advances in Experimental Medicine and Biology (Henun Press, New York 1972).
Assaykeen, T.A.; Clayton, P.L.; Goldfein, A. and Ganong, W.F.: Effect of alpha and beta-adrenergic blocking agents on the renin response to hypoglycaemia and epinephrine in dogs. Endocrinology 87: 1318–1322 (1970).
Ayers, C.R.; Harris, R.H. and Lefer, L.G.: Control of renin release in experimental hypertension. Circulation Research 24: 103–109 (1969).
Baer, L.; Goodwin, F.J. and Laragh, J.H.: Diazoxideinduced renin release in man: Dissociation from plasma and extracellular fluid volume changes. Journal of Clinical Endocrinology and Metabolism 29: 1107–1109(1969).
Barajas, L.: The innervation of the juxtaglomerular apparatus: An electron microscopic study of the innervation of the glomerular arterioles. Laboratory Investigation 13: 916–922 (1964).
Barbeau, A.; Gillo-Joffroy, L.; Boucher, R.; Nowaczynski, W. and Genest, J.: Renin-aldosterone system in Parkinson’s disease. Science 165: 291 (1969).
Beck, N.; Kim, K.S. and Davis, B.B.: Catecholaminedependent cyclic adenosine monophosphate and renin in the dog kidney. Circulation Research 36: 401–405 (1975).
Birbari, A.: Effect of sympathetic nervous system on renin release. American Journal of Physiology 220: 16–18(1971).
Blaine, E.H.: Davis, J.O. and Prewitt, R.L.: Evidence for a renal vascular receptor on the control of renin secretion. American Journal of Physiology 220: 1593–1596(1971).
Blair-West, J.R.; Coghlan, J.P.; Denton, D.A.; Funder, J.W.; Scoggins, B.A. and Wright, R.D.: Inhibition of renin secretion by systemic and intrarenal angiotensin infusions. Amer. J. Physiol. 220: 1309 (1971).
Bourgoignie, J.J.; Catanzaro, E.J. and Perry, H.M. Jr: Renin-angiotensin-aldosterone system during chronic thiazide therapy of benign hypertension. Circulation 37: 27–35 (1968).
Bozovic, L. and Castenfors, J.: The effects of ganglonic blocking on plasma renin activity in exercising and pain-stressed rats. Acta Physiologica Scandinavica 70: 290–293 (1967a).
Bozovic, L. and Castenfors, J.: Effect of dihydrallazine on plasma renin activity and renal function during supine exercise on normal subjects. Acta Physiologica Scandinavica 70: 281–289 (1967b).
Bravo, E.L.; Tarazi, R.C. and Dustan, H.P.: On the mechanism of suppressed plasma-renin activity during beta-adrenergic blockade with propranolol. Journal of Laboratory and Clinical Medicine 83(1): 119–128 (1974).
Bravo, E.L.; Tarazi, R.C.; Dustan, H.P. and Lewis, J.W.: Dissociation between renin and arterial pressure responses to beta-adrenergic blockade in human essential hypertension. Circulation Research 36 (Suppl. 1): 241–247(1975).
Brod, J.; Horbach, L.; Just, H.; Rosenthal, J. and Nicolescu, R.: Acute effects of clonidine on central and peripheral haemodynamics and plasma renin activity. European Journal of Clinical Pharmacology 4: 107–114(1972).
Brown, J.J.; Davies, D.L.; Ferris, J.B.; Fraser, R.; Haywood, E.; Lever, A.R. and Robertson, J.I.S.: Comparison of surgery and prolonged spironolactone therapy in patients with hypertension, aldosterone excess and low plasma renin. British Medical Journal 1: 729–734(1972).
Brown, J.J.; Davies, D.L.; Lever, A.F. and Robertson, J.I.S.: Variations in plasma renin concentration in several physiological and pathological states. Canadian Medical Association Journal 90: 201 (1964).
Brown, J.J.; Davies, D.L.; Lever, A.F. and Robertson, J.I.S.: Plasma renin concentration in human hypertension. IV. Renin in relation to treatment and prognosis. British Medical Journal 2: 268–271 (1966a).
Brown, J.J.; Davies, D.L.; Lever, A.F. and Robertson, J.I.S.: Renin and angiotensin — A survey of some aspects. Postgraduate Medical Journal 42: 153–176 (1966b).
Brown, JJ.; Lever, A.F. and Robertson, J.I.S.: Plasma renin concentration in human hypertension. American Heart Journal 74: 413–418 (1967).
Brown, T.C.; Davis, J.O. and Johnston, C.I.: Acute responses in plasma renin and aldosterone secretion to diuretics. American Journal of Physiology 211: 437 (1966).
Brubacher, E.S. and Vander, A.J.; Sodium deprivation and renin secretion in unaesthetized dogs. American Journal of Physiology 214: 15–19 (1968).
Brunner, H.R.; Laragh, J.H.; Baer, L.; Newton, M.A.; Goodwin, F.J.; Krakoff, L.R.; Baro, R.H. and Buhler, F.R.: Essential hypertension: Renin and aldosterone, heart attack and stroke. New England Journal of Medicine 286: 441–449 (1972).
Brunner, H.R.; Gavras, H.; Laragh, J.H.L.; Marrus, G. and Sealy, J.E.: Renin as risk factor in hypertension: An updated analysis. Abstract No. 438, Vlth International Congress of Nephrology, Florence (1975).
Buhler, F.R.; Laragh, J.H.; Baer, L.; Vaughan, E.D. and Brunner, H.R.: Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases. New England Journal of Medicine 287: 1209–1214 (1972).
Buhler, F.R.; Laragh, J.H.; Vaughan, E.D.; Brunner, H.R.; Gavras, H. and Baer, L.: Antihypertensive action of propranolol. Specific antirenin responses in high and normal renin forms of essential renal, renovascular and malignant hypertension. American Journal of Cardiology 32: 511–522 (1973).
Bunag, R.D.; Page, I.H. and McCubbin, J.W.: Neural stimulation of release of renin. Circulation Research 19: 851–858(1966).
Bunag, R.D.; Page, I.H. and McCubbin, J.W.: Inhibition of renin release by vasopressin and angiotensin. Cardiovascular Research 1: 67 (1967).
Castenfors, J.: Effect of ethacrynic acid on plasma renin activity during supine exercise in normal subjects. Acta Physiologica Scandinavica 70: 215–220 (1967).
Castenfors, J.; Johnsson, H. and Orr, O.L.: Effect of alprenolol on blood pressure and plasma renin activity in hypertensive patients. Acta Medica Scandinavica 193(3): 189–195(1973).
Catt, K.J.; Cran, E.; Zimmett, P.Z.; Best, J.B.; Cain, M.D. and Coghlan, J.P.: Angiotensin II blood levels in human hypertension. Lancet 1: 459–464 (1971).
Chonko, A.M.; Stein, J.H. and Ferris, T.F.: Renin and the kidney. Nephron 15: 279–305 (1975).
Coghlan, J.P.; Blair-West, J.R.; Denton, D.A.; Scoggins, B.A. and Wright, R.D.: Perspectives of aldosterone and renin control. Australia and New Zealand Journal of Medicine 1: 178–197 (1971).
Cohen, E.L.; Conn, J.W. and Rovner, D.R.: Postural augmentation of plasma renin activity and aldosterone excretion in normal people. Journal of Clinical Investigation 46: 418 (1967).
Cooke, C.R.; Brown, T.C.; Zacherle, B.J. and Walker, W.G.: Effect of altered sodium concentration in the distal nephron segments on renin release. Journal of Clinical Investigation 49: 1630–1641 (1970).
Coote, J.H.; Johns, E.J.; MacLeod, V.H. and Singer, B.: Effect of renal nerve stimulation, renal blood flow and adrenergic blockade on plasma renin activity in the cat. Journal of Physiology 226: 15 (1972).
Cruz, A.F.; Noth, R.N.; Helder, R.G. and Mulrow, P.J.: Glucagon stimulation of plasma renin activity in humans. Journal of Clinical Endocrinology and Metabolism 41: 183(1975).
Davis, J.O.: What signals the kidney to release renin. Circulation Research 28: 301–304 (1971).
Davis, J.O.: The control of renin release. American Journal of Medicine 55: 333–350 (1973).
De Champlain, J.; Genest, J.; Veyrat, R. and Boucher, R.: Factors controlling renin in man. Archives of Internal Medicine 117: 355 (1966).
Demers, R.G.; Hendler, R.; Allan, R.P. and Boyd, J.: Edema and increased plasma renin activity in lithium treated patients. Behavioural Neuropsychiatry 3(9): 20–24 (1971).
Doyle, A.E. and Jerums, G.: Sodium balance plasma renin and aldosterone in hypertension. Circulation Research 26: 11267–11275(1970).
Dunn, M.J. and Tannen, R.L.: Low renin hypertension. Kidney International 5: 317–325 (1974).
Editorial: Angiotensin myocardial infarction and strokes. Lancet 1: 1273–1274 (1972).
Editorial: New thoughts on essential hypertension. British Medical Journal 1: 121 (1972).
Eide, L; Löyning, E. and Kiil, F.: Potentiation of renin release by combining renal arterial constriction of β-adrenergic stimulation. Scandinavian Journal of Clinical Laboratory Investigation 34: 301–310 (1974).
Esch, I.; Hacheta, P.; Gaul, G. and Kneussel, K.: Der Krankheitsrerlauf der essentiellen Hypertonie bei vermindertor Plasmareninaktivität. Wiener Klinische Wochenschrift 85: 617–621 (1973).
Esler, M.D.: Effect of practolol on blood pressure and renin release in man. Clinical Pharmacology and Therapeutics 15: 484–489 (1974).
Esler, M.D. and Nestel, P.J.: Renin and sympathetic nervous system responsiveness to adrenergic stimuli in essential hypertension. American Journal of Cardiology 32: 643–649 (1973a).
Esler, M.D. and Nestel, P.J.: Evaluation of practolol in hypertension. British Heart Journal 35: 469–474 (1973b).
Fajola, A.F.; Martz, B.L. and Helmer, O.M.: Plasma renin activity during supine exercise in offspring of hypertensive parents. Journal of Applied Physiology 25: 410(1968).
Fraser, R.; James, V.H.T.; Brown, J.J.; Issac, P.; Lever, A. and Robertson, J.I.S.: Effect of angiotensin and of frusemide on plasma aldosterone cortisol and renin in man. Lancet 2: 289 (1965).
Fyhrquist, F.; Kurppa, K. and Huuskonen, M.: Plasma renin activity, blood pressure and sodium excretion during treatment with clonidine. Acta Medica Scandinavica 197: 457–461 (1975).
Ganong, W.F.: The role of catecholamines and acetylcholine in the regulation of endocrine function. Life Sciences 15: 1401–1414 (1974).
Ganong, W.F.: Sympathetic effects on renin secretion: Mechanism and physiological role in control of renin secretion; in Assaykeen (Ed.) Advances in Experimental Medicine and Biology, p. 17–32 (Plenum Press, New York 1972).
Gordon, R.D.; Kuchel, O.; Liddle, G.W. and Island, D.P.: Role of the sympathetic nervous system in regulating renin and aldosterone production in man. Journal of Clinical Investigation 46: 599 (1967).
Gotshall, R.W.; Davis, J.O.; Shade, R.E.; Spielman, W.; Johnson, J.A. and Braverman, B.: Effects of renal denervation on renin release in sodium depleted dogs. American Journal of Physiology 225: 344–349 (1973).
Gottlieb, T.B.; Katz, F.H. and Chidsey, C.A.: Combined therapy with vasodilator drugs and beta-adrenergic blockade in hypertension. Circulation 45: 471–483 (1972).
Gross, F.: The renin-angiotensin system in hypertension. Annals of Internal Medicine 75: 777–784 (1971).
Gross, F. and Möhring, J.: Renal pharmacology with special emphasis on aldosterone and angiotensin. Pharmacology Review 10: 57–90 (1973).
Gutman, Y. and Benzakein, F.: Effect of phenformin and chlorpropamide on renin activity in the rat. Experimentia 27: 1313–1314 (1971).
Gutman, Y.; Benzakein, F. and Liuneh, P.: Polydipsia induced by isoprenaline and by lithium: Relation to kidneys and renin. European Journal of Pharmacology 16: 380–385(1971).
Gutman, Y.; Tamir, N. and Benzakein, F.: Effect of lithium on plasma renin activity. European Journal of Pharmacology 24(3): 347–351 (1973).
Haber, E.; Koerner, T.; Page, L.B.; Kliman, B. and Purndoe, A.; Application of radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal subjects. Journal of Clinical Endocrinology 29: 1349–1355 (1969).
Halushka, P.V. and Keiser, H.R.: Acute effects of alphamethyldopa on mean blood pressure and plasma renin activity. Circulation Research 35: 458–463 (1974).
Hansson, L.: Beta-adrenergic blockade in essential hypertension. Effects of propranolol on hemodynamic parameters and plasma renin activity. Acta Medica Scandinavica Suppl. 550: 1–40 (1973).
Hansson, L. and Zweifler, A.J.; The effect of propranolol on plasma renin activity and blood pressure in mild essential hypertension. Acta Medica Scandinavica 195(5): 397–401 (1974).
Hedeland, H.; Dymling, J.F. and Hökfelt, B.: Catecholamines, renin and aldosterone in postural hypotension. Acta Endocrinologica 62: 399 (1969).
Hodge, R.L.; Lowe, R.D. and Vane, J.R.: The effects of alteration of blood volume on the concentration of circulating angiotensin in anaesthetized dogs. Journal of Physiology 185: 613–618 (1966).
Hofbauer, K.G.; Zschiedrich, H.; Hackenthal, E. and Gross, F.: Function of the renin-angiotensin system on the isolated perfused rat kidney. Circulation Research 34: 1193–1201 (1974).
Hokfelt, B.; Hedeland, H. and Dymling, J.F.: Studies on catecholamines renin and aldosterone following catapresan (2 (2,6-dichlor-phenylamine)-2-imidazoline hydrochloride) in hypertensive patients. European Journal of Pharmacology 10: 389–397 (1970).
Imbs, J.L.; Schmidt, M. and Schwartz, J.: Effect of dopamine on renin secretion in the anaesthetized dog. European Journal of Pharmacology 33: 151–157 (1975).
Jerums, G. and Doyle, A.E.: Renal sodium handling and responsiveness of plasma renin levels in hypertension. Clinical Science 37: 79–90 (1969).
Johns, E.J.; Richards, H.K. and Singer, B.: Effects of adrenaline, nor adrenaline, isoprenaline and salbutamol on the production and release of renin by isolated renal cortical cells of the cat. British Journal of Pharmacology 53: 67–73 (1975).
Johns, E.J. and Singer, B.: Specificity of blockade of renal renin release by propranolol in the cat. Clinical Science and Molecular Medicine 47: 331–343 (1974).
Johns, E.J. and Singer, B.: Comparison of the effects of propranolol and ICI 66082 in blocking the renin releasing effect of renal nerve stimulation in the cat. British Journal of Pharmacology 52: 315–318 (1974).
Johnson, J.A.; Davis, J.O. and Witty, R.T.: Effects of catecholamines and renal nervr stimulation on renin release in the non-filtering kidney. Circulation Research 29: 646–653 (1971).
Johnston, C.I.; Anavekar, N.; Chua, K.G. and Louis, W.J.: Plasma renin and angiotensin levels in human hypertension following treatment. Clinical Science and Molecular Medicine (Suppl.) 45: 4875–4903 (1973).
Johnston, C.I.; Mendelsohn, F.A.O. and Doyle, A.E.: Metabolism of angiotensin II in sodium depletion and hypertension in humans. Circulation Research 30: 1203–1213(1972).
Johnston, C.I.; Mendelsohn, F.A.O.; Hutchinson, J.H. and Morris, B.: Composition of juxtaglomerular granules isolated from rat kidney cortex; in Sambhi (Ed.) Mechanisms of Hypertension. Proceedings of International Workshop Conference, Excerpta Medica International Congress Series No. 302 (1973).
Kaneko, Y.; Ikeda, T.; Takeda, T.; Inoue, G.; Tagawa, H. and Ueda, H.: Renin release in patients with benign essential hypertension. Circulation 38: 353–362 (1968).
Klaus, D.; Boxskor, A.; Fleischer, K.; Simsch, A.: Stimulier- und Supprimierbarkeit der Reninsekretion durch Natrumentzugbzw. Klinische Wochenschrift 48: 1024–1033 (1970).
Kotchen, T.O.; Hartley, L.H.; Rice, T.W.; Mougey, E.H.; Jones, L.G. and Mason, J.W.: Renin, norepinephrine and epinephrine responses to graded exercise. Journal of Applied Physiology 31: 178–184 (1971).
Kuchel, O.; Fishman, L.M.; Liddle, G.W. and Michelakis, A.: Effect of diazoxide on plasma renin activity in hypertensive patients. Annals of Internal Medicine 67: 791–799(1967).
Laragh, J.H.: Vasoconstriction-volume analysis for understanding and treating hypertension: The use of renin and aldosterone profiles. American Journal of Medicine 55: 262–274 (1973).
Laragh, J.H.; Baer, L.; Brunner, H.R.; Buhler, F.R.; Sealey, J.E. and Darracott Vaughan, E.: Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. American Journal of Medicine 52: 633–652 (1972).
Leenen, F.H. and McDonald, R.H.: Effect of isoproterenol on blood pressure plasma renin activity and water intake in rats. European Journal of Pharmacology 26: 129–135 (1974).
Leenen, F.H.H.; Redmond, D.P. and McDonald, R.H.: Alpha and beta adrenergic-induced renin release in man. Clinical Pharmacology and Therapeutics 18: 31–38(1975).
Lewis, E.J.; Blaufox, M.D. and Hickler, R.G.: Renin secretion by the denervation kidney. British Journal of Medicine 2: 1430–1431 (1966).
Lewis, P.J. and Lee, M.R.: Renin release in the rabbit produced by ergometrine infusions. British Journal of Experimental Pathology 53: 150–152 (1972).
Loeffler, J.R.; Stockigt, J.R. and Ganong, W.F.: Effect of alpha and beta adrenergic blocking agents on the increase in renin secretion produced by stimulation of the renal nerves. Neuroendocrinology 10: 129 (1972).
Louis, W.J.; Morgan, T.O.; Anavekar, S.N.; and Doyle, A.E.: Evaluation of MK 950 as an antihypertensive agent; in Magnani (Ed.) Beta Adrenergic Blocking Agents in the Management of Hypertension and Angina Pectoris (Raven Press, New York 1974).
Lowder, S.C. and Liddle, G.W.: Effects of guanethidine and methyldopa on a standardized test for renin responsiveness. Annals of Internal Medicine 82: 757–760(1975).
Lyons, H.J. and Churchill, P.C.: Renin secretion from rat renal cortical cell suspensions. American Journal of Physiology 228: 1835–1839 (1975).
Maebashi, M. and Yoshinaga, K.: Changes in plasma renin after administration of spironolactone. Japanese Circulation Journal 31: 435–439 (1967).
Marcia, G.; Romero, J.C. and Shepherd, J.T.: Continuous inhibition of renin release in dogs by vagally innervated receptors in the cardiopulmonary region. Circulation Research 36: 529–535 (1975).
Massingham, R. and Hayden, M.C.: A comparison of the effects of prazosin and hydralazine in blood pressure, heart rate and plasma renin activity in conscious renal hypertensive dogs. European Journal of Pharmacology 30: 121–124(1975).
McAllister, R.G.; Van Way, C.W.; Dayani, K.; Anderson, W.J.; Temple, E.; Michelakis, A.M.; Coppage, W.S. and Oates, J.A.: Malignant hypertension: Effect on therapy on renin and aldosterone. Circulation Research (Suppl.) 28(5): 160–174 (1971).
Meekers, J.; Missolten, A.; Fagard, R.; Demuynck, D.; Harvengt, C; Pas, P.; Billiet, L. and Amery, A.: Predictive value of various parameters for the antihypertensive effect of beta blocker ICI 66082. Archives Internationales de Pharmacologie et Therapie 213: 294–306 (1975).
Meyer, P.; Ménard, J.; Alexandre, J.M. and Weil, B.: Correlations between plasma renin, haematocrit and natriuresis. Revue Canadienne de Biologie 25: 111 (1966).
Meyer, P.; Ménard, J.; Papanicolaou, N. and Milliez, P.: Re-evaluation of the role of hypovolaemia on the release of renin. Experimentia 25: 498–499 (1969).
Meurer, K.A.; Dieter, H.M.; Schmidt, D.; Schmidt, H.J. and Kaufmann, W.: Die β-adrenergen rezeptoren als Vermittler der reninfreisetzung. Deutsche Medizinische Wochenschrift 96: 749–751 (1971).
Meurer, K.A.; Rosskamp, E.; Krause, D.K. and Kaufmann, W.: Stimulating action of various drugs on PRA; in Genest and Koiw (Eds) Hypertension p.140–148 Springer-Verlag, Berlin 1972).
Michelakis, A.M.; Caudle, J. and Liddle, G.W.: In vitro stimulation of renin production by epinephrine, norepinephrine and cyclic AMP. Proceedings of the Society of Experimental Biology and Medicine 130: 748–753(1969).
Michelakis, A.M. and McAllister, R.G.: The effect of chronic adrenergic receptor blockade on plasma renin activity in man. Journal of Clinical Endocrinology and Metabolism 34: 386–394 (1972).
Michelakis, A.M. and Robertson, D.: Plasma renin activity and levodopa in Parkinson’s disease. Journal of the American Medical Association 213: 83–85 (1970).
Mogil, R.A.; Itskovitz, H.D.; Russell, J.H. and Murphy, J.J.: Renal innervation and renin activity on salt metabolism and hypertension. American Journal of Physiology 216: 693–697 (1969).
Mohammed, S.; Fajola, A.F.; Privitera, P.J.; Lipicky, R.J.; Martz, B.L. and Gaffney, T.E.: Effect of methyldopa on plasma renin activity in man. Circulation Research 25: 543–548(1969).
Morgan, T.O.; Roberts, R.; Carney, S.L.; Louis, W.J. and Doyle, A.E.: β-adrenergic receptor blocking drugs hypertension, plasma renin. British Journal of Clinical Pharmacology 2: 159–164 (1975).
Michelakis, A.M. and Robertson, D.: Plasma renin activity and levodopa in Parkinson’s disease. Journal of the American Medical Association 213: 83–85 (1970).
Mogil, R.A.; Itskovitz, H.D.; Russell, J.H. and Murphy, J.J.: Renal innervation and renin activity on salt metabolism and hypertension. American Journal of Physiology 2 6: 693–697 (1969).
Mohammed, S.; Fajola, A.F.; Privitera, P.J.; Lipicky, R.J.; Martz, B.L. and Gaffney, T.E.: Effect of methyldopa on plasma renin activity in man. Circulation Research 25: 543–548(1969).
Morgan, T.O.; Roberts, R.; Carney, S.L.; Louis, W.J. and Doyle, A.E.: β-adrenergic receptor blocking drugs hypertension, plasma renin. British Journal of Clinical Pharmacology 2: 159–164 (1975).
Morris, B.J.; Nixon, R.L. and Johnston, C.I.: Release of renin from glomeruli isolated from rat kidney. Clinical and Experimental Pharmacology and Physiology (In press, 1976).
Muller, J. and Barajas, L.: Electron microscopic and histochemical evidence for a tubular innervation in the renal cortex of the monkey. Journal of Ultrastructure Research 41: 533–549 (1972).
Naughton, R.J.; Bertoncello, I. and Skinner, S.L.: Abolition of the renin releasing action of frusemide by acute renal denervation in dogs. Clinical and Experimental Pharmacology and Physiology 2: 213–227 (1975).
Nielsen, L. and Moller, L: On the mechanism of renin stimulation. Acta Medica Scandinavica 186: 493–497 (1969).
Nilsson, O.: The adrenergic innervation of the kidney. Laboratory Investigation 14: 1392–1395 (1965).
Nolly, H.L.; Reid, I.A. and Ganong, W.F.: Effect of theophylline and adrenergic blocking drugs on the renin response to norepinephrine in vitro. Circulation Research 35: 575–579 (1974).
Nomura, G.; Kurosaki, M.; Takabatake, T.; Kibe, Y. and Takeuchi, J.: Reinnervation and renin release after unilateral renal denervation in the dog. Journal of Applied Physiology 33: 649–655 (1972).
O’Malley, K.; Velasco, M.; Wells, J. and McNay, J.L.: Control plasma renin activity and changes in sympathetic tone as determinants of minoxidil-induced increase in plasma renin activity. Journal of Clinical Investigation 55: 230–235 (1975).
Onesti, G.; Schwartz, A.B.; Kim, K.E.; Paz, V.; Martinez, C. and Swartz, C: Antihypertensive effect of clonidine. Circulation Research 28 (Suppl. 2): 53–69 (1971).
Oparil, S. and Haber, E.: The renin angiotensin system. New England Journal of Medicine 291: 389–401, 446–457 (1974).
Otsuka, K.; Assaykeen, T.A.; Goldfein, A. and Ganong, W.F.: Effect of hypoglycaemia on plasma renin activity in dogs. Endocrinology 87: 1306–1317 (1970).
Page, I.H. and Bumpus, F.M. (Eds): Angiotensin; in Handbook of Experimental Pharmacology, New Series Vol. 37 (Springer-Verlag, Berlin Heidelberg & New York 1974).
Page, I.H. and McCubbin, J.W. (Eds): in Renal Hypertension (Year Book Medical Publishers, Chicago 1968).
Passo, S.S.; Assaykeen, T.A.; Otsuka, K.; Wise, B.L.; Goldfein, A. and Ganong, W.F.: Effect of stimulation of the medulla oblongata on renin secretion in dogs. Neuroendocrinology 7: 1–10 (1971).
Peskar, B.; Meyer, D.K.; Tauchmann, U. and Hertting, G.: Influence of isoproteronol, hydrallazine and phentolamine on the renin activity of plasma and renal cortex of rats. European Journal of Pharmacology 9: 394–396 (1970).
Pettinger, W.A.; Campbell, W.B. and Keeton, K.: Adrenergic component of renin release induced by vasodilating antihypertensive drugs in the rat. Circulation Research 33: 82–86(1973).
Pettinger, W.A. and Mitchell, H.C.: Renin release, saralasin and the vasodilator — beta-blocker drug interaction in man. New England Journal of Medicine 292: 1214–1217(1975).
Peytremann, A.; Favre, L. and Vallotton, M.B.: Effect of cold pressure test and 2 deoxy-D-glucose in plasma renin activity in man. European Journal of Clinical Investigation 2: 432 (1972).
Reid, I.A.; Schrier, R. and Earley, L.: An effect of extrarenal β-adrenergic stimulation in the release of renin. Journal of Clinical Investigation 51: 1861–1869 (1972).
Reid, I.A.; Stockigt, J.R.; Goldfein, A. and Ganong, W.F.: Stimulation of renin secretion in dogs by theophyline. European Journal of Pharmacology 7: 325–332 (1972).
Reid, I.A.; MacDonald, D.M.; Pachnis, B. and Ganong, W.F.: Studies concerning the mechanism of suppression of renin secretion by clonidine. Journal of Pharmacology and Experimental Therapeutics 192: 713–721 (1975).
Rosenthal, J.; Boucher, R.; Nowaczynski, W. and Genest, J.: Acute changes in plasma volume, renin activity and free aldosterone levels in healthy subjects following frusemide administration. Canadian Journal of Physiology and Pharmacology 46: 85 (1967).
Rosset, E. and Veyrat, R.: Release of renin by human kidney slices, in vitro effect of angiotensin II, norepinephrine and aldosterone. European Journal of Clinical and Biological Research 16: 792–794 (1971).
Salvetti, A.; Arzilli, F. and Zucchelli, G.C.: The effect of clonidine on plasma renin activity in human hypertension. Clinical Science and Molecular Medicine (Suppl.)45: 1855(1973)
Shade, R.E.; Davis, J.O.; Johnson, J.A.; Gotshall, R.W. and Spielman, W.S.: Mechanism of action of angiotensin II and antidiuretic hormone on renin secretion. American Journal of Physiology 224: 926 (1973).
Shopsin, B.; Sathananthan, G. and Gershon, S.: Plasma renin response to lithium in psychiatric patients. Clinical Pharmacology and Therapeutics 14: 561–564 (1973).
Slotkoff, L.M.; Eisner, G.M.; Adamson, W. and Lillienfield, L.S.: The role of the autonomic nervous system in intrarenal regulation of renin secretion. Proceedings of the Society of Biology and Medicine 137: 683–691 (1971).
Spark, R.F. and Melby, J.C.: Aldosteronism in hypertension: The spironolactone response test. Annals of Internal Medicine 69: 685 (1968).
Stokes, G.S.; Weber, M.A. and Thorneil, I.R.: Betablockers and plasma renin activity in hypertension. British Medical Journal 1: 60–62 (1974).
Stroobandt, R.; Fagaro, R. and Amery, A.K.P.C: Are patients with essential hypertension and low renin protected against stroke and heart attack? American Heart Journal 86: 781–787 (1973).
Sullivan, J.M.; Nakano, K.K. and Tyler, R.: Plasma renin activity during levodopa therapy. Journal of American Medical Association, 224: 1726–1728 (1973).
Sweet, C.S.; Wengler, H.C. and O’Malley, T.A.: Antagonism of hydrochlorothiazide-induced elevations, in plasma renin activity by methyldopa in conscious renal hypertensive dogs. Canadian Journal of Physiology and Pharmacology 52: 1036–1040 (1974).
Tanigawa, H.; Allison, D.J. and Assaykeen, T.A.: A comparison of the effects of various catecholamines on plasma renin activity alone and in the presence of adrenergic blocking agents; in Genest and Koiw (Eds) Hypertension, p.37–44 (Springer-Verlag, Berlin 1972).
Tanigawa, H.; Dua, S.L. and Assaykeen, T.A.: Effect of renal and adrenal denervation in the renin response to slow haemorrhage in dogs. Clinical and Experimental Pharmacology and Physiology 1: 325–332 (1974).
Tarazi, R.C.; Dustan, H.P. and Frohlich, E.D.: Long-term thiazide therapy in essential hypertension: Evidence for persistent alteration in plasma volume and renin activity. Circulation 41: 709–717 (1970).
Thurau, K.: Aspects in renal physiology. Klinische Wochenschrift 50: 221–225 (1972).
Thurau, K.; Dahlheim, H.; Gruner, A.; Mason, J. and Granger, P.: Activation of renin in the single juxtaglomerular apparatus by sodium chloride in the tubular fluid at the macula densa. Circulation Research 30 (Suppl. 2): 182–186 (1972).
Ueda, H.; Yagi, S. and Kaneko, Y.: Hydrallazine and plasma renin activity. Archives of Internal Medicine 122: 387–391 (1968).
Vagnucci, A.H. and Shapiro, A.P.: Perspective on the renin agiotensin aldosterone system in hypertension. Metabolism 23: 272–302 (1974).
Vander, A.J.: Control of renin release. Physiological Review 47: 359–382(1967).
Vander, A.J.: Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs. American Journal of Physiology 209: 659–662 (1965).
Vander, A.J.: Inhibition of renin release in the dog by vasopressin and vasotocin. Circulation Research 23: 605 (1968).
Vander, A.J. and Carlson, J.; Mechanism of the effects of frusemide on renin secretion in anesthetized dogs. Circulation Research 25: 145–151 (1969).
Vander, A.J. and Geelhoed, G.W.: Inhibition of renin secretion by angiotensin. Proceedings of Society of Experimental Biological Medicine 120: 399 (1965).
Vander, A.J. and Luciano, J.R.: Effects of mercurial diuretics and acute volume depletion on renin release in dog. American Journal of Physiology 212: 651 (1967).
Vandongen, R.: Adrenergic receptor mechanisms and renin secretion. Australian and New Zealand Journal of Medicine 4: 237–242 (1974).
Vandongen, R.: Inhibition of renin secretion in the isolated rat kidney by antidiuretic hormones. Clinical Science and Molecular Medicine 49: 73–76 (1975).
Vandongen, R. and Peart, W.S.: The inhibition of renin secretion by alpha-adrenergic stimulation in the isolated rat kidney. Clinical Science and Molecular Medicine 47: 471–479 (1974).
Vandongen, R.; Peart, W.S. and Boyd, G.W.: Adrenergic stimulation of renin secretion on the isolated perfused rat kidney. Circulation Research 32: 290–296 (1973).
Vaughan, E.D.; Laragh, J.H.; Gavras, I.; Bühler, F.R.; Gavras, H.; Brunner, H.R. and Baer, L.: Volume factor in low and normal renin essential hypertension. American Journal of Cardiology 32: 523–532 (1973).
Voudoukis, I.J.; On the role of hydrallazine in renal hemodynamics and secretion of renin. American Heart Journal 72: 140–141 (1966).
Wallach, L.; Nyarai, I. and Dawson, K.G.: Stimulated renin: A screening test for hypertension. Annals of Internal Medicine 82: 27–34 (1975).
Wathen, R.L.; Kingsbury, W.S.; Stouder, D.A.; Schneider, E.G. and Rostorfer, H.H.: Effects of infusion of catecholamines and angiotensin II on renin release in anesthetized dogs. American Journal of Physiology 209: 1012–1017(1965).
Weber, M.A.; Stokes, G.S. and Gain, J.M.: Comparison of the effects on renin release of beta adrenergic antagonists with differing properties. Journal of Clinical Investigation 54: 1413–1419 (1974).
Weidmann, P.; Hirsch, D.; Maxwell, M.H.; Rokun, L. and Schroth, P.: Plasma renin and blood pressure during treatment with methyldopa. American Journal of Cardiology 34: 671–676 (1974).
Weinberger, M.H.; Dowdy, A.J.; Nokes, G.W. and Luetscher, J.A.: Plasma renin activity and aldosterone secretion on hypertensive patients during high and low sodium intake and administration of diuretic. Journal of Clinical Endocrinology 28: 359–369 (1968).
Wilcox, C.S.; Aminoff, M.J.; Kurtz, A.B. and Slater, J.D.H.: Comparison of the renin response to dopamine and noradrenaline in normal subjects and patients with autonomic insufficiency. Clinical Science and Molecular Medicine 46: 481 (1974).
Williams, G.H.; Rose, L.I.; Dluhy, R.G.; McCaughn, D.; Jagger, P.I.; Hickler, R.B. and Lauler, D.P.: Abnormal responsiveness of the renin aldosterone system to acute stimulation in patients with essential hypertension. Annals of Internal Medicine 72: 317–326 (1970).
Winer, N.; Chokshi, O.S. and Walkenhorst, W.G.: Effects of cyclic AMP, sympathomimetic amines and adrenergic receptor antagonists on renin secretion. Circulation Research 29: 239–248 (1971).
Winer, N.; Chokshi, D.S.; Yoon, M.S. and Freedman, A.D.: Adrenergic receptor mediation of renin secretion. Journal of Clinical Endocrinology and Metabolism 29: 1168–1175 (1969).
Witty, R.T.; Davis, J.O.; Johnson, J.A. and Prewitt, R.L.: Effects of papaverine and haemorrhage on renin secretion in the non-filtering kidney. American Journal of Physiology 221: 1666–1671 (1971).
Wogermark, J.; Ungerstedt, U. and Ljungvist, A.: Sympathetic innervation of the juxtaglomerular cells of the kidney. Circulation Research 22: 149–153 (1968).
Zehr, J.E. and Feigl, E.O.: Suppression of renin activity by hypothalamic stimulation. Circulation Research 32: 117–126(1973).
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Johnston, C.I. Effect of Antihypertensive Drugs on the Renin-Angiotensin System. Drugs 12, 274–291 (1976). https://doi.org/10.2165/00003495-197612040-00003
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DOI: https://doi.org/10.2165/00003495-197612040-00003