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Once-Daily Administration of Antiretrovirals

Pharmacokinetics of Emerging Therapies

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Abstract

Adherence to therapy is of critical importance for the long-term success of the treatment of HIV infection. Once-daily administration of antiretroviral agents is appealing, as it may increase patient’s adherence. The pharmaceutical industry is making huge efforts to develop drugs or combinations of drugs with pharmacokinetic properties allowing once-daily administration. The major pharmacokinetic requirement for once-daily administration is that the intracellular concentration of the antiretroviral or its active metabolite remains above the minimal concentration that can inhibit viral replication during the entire 24-hour period. Soon, all three major classes of antiretroviral agents will be available as once-daily formulations. However, only a few clinical trials have yet assessed the efficacy and safety of truly once-daily antiretroviral combinations. Preliminary results from these small pilot studies suggest that once-daily administration of antiretrovirals is a feasible approach. Large comparative trials are needed before the real benefits of such a strategy can be fully assessed.

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Acknowledgements

No sources of funding were used to assist in the preparation of this manuscript. Dr Molina has received consulting and lecture fees from Triangle, GSK, Abbott, BMS, Roche and Gilead. Dr Taburet has recevied research grants from GSK, Gilead, BMS, Roche and Abbott.

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  1. Clinical Pharmacy, Hospital Biçêtre (Assistance Publique/ Hôpitaux de Paris), 78 rue du Général Leclerc, 94270, Kremlin Biçêtre, France

    Anne-Marie Taburet & Sabine Paci-Bonaventure

  2. Hospital Bichat, Assistance Publique-Hôpitaux de Paris, France

    Gilles Peytavin

  3. Hospital Saint-Louis, Assistance Publique-Hôpitaux de Paris, France

    Jean-Michel Molina

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  1. Anne-Marie Taburet
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  2. Sabine Paci-Bonaventure
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Taburet, AM., Paci-Bonaventure, S., Peytavin, G. et al. Once-Daily Administration of Antiretrovirals. Clin Pharmacokinet 42, 1179–1191 (2003). https://doi.org/10.2165/00003088-200342140-00001

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