Abstract

Convergent biomimetic technologies are a popular biotechnological direction. They include approaches that rely on biological and membrane processes, which require special engineering support, e.g., hybrid biomembrane systems. This article reviews scientific achievements in the sphere of biomembrane systems, their design, technological capabilities, and development prospects. The review covered scientific publications on the development, research, application, problems, and prospects of biomembrane systems published in 2013–2024 and registered in Web of Science, Google Scholar, Scopus, Elsevier, and eLIBRARY.RU. The scientific and technical data made it possible to identify the main features of biomembrane systems and classify them. Biomembrane systems improve the cultivation of yeast, lactic and acetic acids, and other metabolites. In lactic acid production, biomembrane systems increase the process efficiency by tenfold: the yield reaches 50 g/L×h with a product content of 100 g/L. Biomembrane systems demonstrate excellent prospects as a source of new progressive biotechnologies. However, they remain understudied for industrial use. The organization, structure, performance, and development of biomembrane processes and systems are highly relevant as part of new effective and economical convergent biomimetic technologies but require additional research.

Keywords

Membrane bioreactor, fermentation system, biotechnology, engineering biotechnology, microbial cultivation

REFERENCES

1. Kovalchuk MV, Naraykin OS. Nature-like technologies – New opportunities and threats. Security Index. 2016;22(3–4):103–108 (In Russ.) https://elibrary.ru/YRNQYF
2. Kovalchuk MV, Naraykin OS, Yatsishina EB. Convergence of science and technology – A new stage of scientific and technological development. Russian Studies in Philosophy. 2013;(3):3–11. (In Russ.) https://elibrary.ru/PYKLUT
3. Kovalchuk MV, Naraykin OS, Yatsishina EB. Nature-like technologies: New opportunities and new challenges. Herald of the Russian Academy of Sciences. 2019;89(5): 455–465. (In Russ.) https://www.doi.org/10.31857/s0869-5873895455-465
4. Fedorenko BN. Industrial bioengineering: Engineering support for biotechnological production. Saint Petersburg: Professia; 2020. 518 p. (In Russ.)
5. Fedorenko BN, Yablokov AE, Yakushev AO. Engineering support of convergent nature-like technologies. Factory of the future: Shifting to advanced digital and smart production and robotic systems in the food industry: Conference proccedings. Moscow: MSUFP; 2021;399–407. (In Russ.)
6. Fedorenko BN. Engineering of convergent biomimetic technologies based on biomembrane processes and systems. Moscow: Rosbiotech; 2024. 576 p. (In Russ.)
7. Antipov ST, Bredikhin SA, Klyuchnikov AI, Panfilov VA, Fedorenko BN. Bioreactors for the future of food technology: Theory and application. Saint Petersburg: Lan’; 2022. 524 p. (In Russ.)
8. Klyuchnikov AI, Fedorenko BN, Antipov ST, Panfilov VA. Fundamental creation concepts for food technologies bioreactors constructions of the future. Bulletin of the Kerch State Marine Technological University. 2023;(1):130–137.
9. Dostalek M, Häggstrom M. A filter fermenter apparatus and control equipment. Biotechnology and Bioengineering. 1982;24(9):2077–2086. https://www.doi.org/10.1002/bit.260240914
10. Swittsov AA, Markvichev NS, Kurakov VV. Membrane bioreactors in biotechnology. Review. Moscow: All-Union Scientific Research Institute of Certification Minmedmicrobioprom; 1986. 36 p. (In Russ.)
11. Soifer RD. Membrane technology of biologically active substances. Journal of the Mendeleyev All-Union Chemical Society. 1987;32(6):661–669. (In Russ.)
12. Kudryashov VL. Membrane bioreactor is a new hybrid equipment for the production of food biologically active substances, biological products and wastewater treatment. Food Processing Industry. 2018;(1):14–17. (In Russ.) https://elibrary.ru/YNTMHG
13. Kuznetsov NA, Beloded AV, Derunets AS, Grosheva VD, Vakar LL, et al. Biosynthesis of lactic acid in a membrane bioreactor for cleaner technology of polylactide production. Clean Technologies and Environmental Policy. 2017;19(3):869–882. https://www.doi.org/10.1007/s10098-016-1275-z
14. Mukhachev SG, Alexandrovskaya YuP, Filippova NK, Yemelyanov VM. Kinetics of aerobic alcohol yeast cultivation in a membrane bioreactor. Herald of Kazan Technological University. 2003;(2):168–172. (In Russ.) https://elibrary.ru/ HUWHJJ
15. Shavaliev MF, Mukhachev SG, Valeeva RT, Yemelyanov VM. Inoculator with membrane gas supply device as a means of improving the asepsis of alcohol production. Herald of Kazan Technological University. 2011;(5):147–149. (In Russ.) https://elibrary.ru/NPIXVT
16. Nedovic V, Willaert R. Fundamentals of cell immobilisation biotechnology. Berlin: Springer Science & Business Media; 2013. 555 p.
17. Eibl R, Eibl D, Portner R, Catapano G, Czermak P. Cell and tissue reaction engineering: Principles and practice. Berlin: Springer; 2009. 363 p.
18. Stepanov SV, Stepanov AS, Stashok YuE, Blinkova LA. Modular membrane bioreactors. Water Supply and Sanitary Technique. 2013;(8):51–55. (In Russ.) https://elibrary.ru/QZHNYJ
19. Vorobiova ES, Safarov RR, Guseva EV, Menshutina NV. Simulation of hydrodinamics in the hollow fiber membrane for cultivation of mammalian cells. Advances in chemistry and chemical technology. 2015;29(4):72–74. (In Russ.) https://elibrary.ru/SLIZFV
20. van Bentem AGN, Petri CP, Schyns PFT, van der Roest HF. Membrane bioreactors: Operation and results of an MBR wastewater treatment plant. London: IWA; 2007. 100 p. https://doi.org/10.2166/9781780402017
21. Judd S, Judd C. The MBR Book: Principles and applications of membrane bioreactors in water and wastewater treatment. Oxford: Elsevier; 2006. 325 p.
22. Yang W, Cicek N, Ilg J. State-of-the-art of membrane bioreactors: Worldwide research and commercial applications in North America. Journal of Membrane Science. 2006;270(1–2):201–211. https://doi.org/10.1016/j.memsci.2005.07.010
23. Stepanov SV. Technological calculation of aerotanks and membrane bioreactors. Moscow: ACB; 2023. 224 p. (In Russ.)
24. Kozlovskiy R, Shvets V, Kuznetsov A. Technological aspects of the production of biodegradable polymers and other chemicals from renewable sources using lactic acid. Journal of Cleaner Technology. 2017;155(1):157–163. https://doi.org/ 10.1016/j.jclepro.2016.08.092
25. Smirnova IV, Krechetnikova AN, Gernet MV. Way of receivtion of mash in spirits manufacture with ultrasonics treatment of raw. Storage and Processing of Farm Products. 2007;(9):68–69. (In Russ.) https://elibrary.ru/IBSBAL
26. Dey P, Pal P. Direct production of l (+) lactic acid in a continuous and fully membrane-integrated hybrid reactor system under non-neutralizing conditions. Journal of Membrane Science. 2012;389:355–362. https://doi.org/10.1016/j.memsci. 2011.10.051
27. Giorno L, Chojnacka K, Donato L, Drioli E. Study of a cell-recycle membrane fermentor for the production of lactic acid by Lactobacillus bulgaricus. Industrial & Engineering Chemistry Research. 2002;41(3):433–440. https://doi.org/ 10.1021/ie010201r
28. Nishiwaki A, Dann I. Comparison of lactic acid productivities at high substrate conversions in a continuous two-stage fermenter with cell recycle using different kinetic models. Chemical Engineering Communications. 2005;192(2):219–236. https://doi.org/10.1080/00986440590473335
29. Xu G, Chu J, Wang Y-H, Zhuang Y-P, Zhang S-L, et al. Development of a continuous cell-recycle fermentation system for production of lactic acid by Lactobacillus paracasei. Process Biochemistry. 2006;41(12):2458–2463. https://doi.org/ 10.1016/j.procbio.2006.05.022
30. Pal P, Sikder J, Roy S. Giorno L. Process intensification in lactic acid production: A review of membrane based processes. Chemical Engineering and Processing: Process Intensification. 2009;48(11–12):1549–1559. https://doi.org/10.1016/ j.cep.2009.09.003
31. Lu Z, Wei M, Yu L. Enhancement of pilot scale production of l(+)-lactic acid by fermentation coupled with separation using membrane bioreactor. Process Biochemistry. 2012;47(3):410–415. https://doi.org/10.1016/j.procbio.2011.11.022
32. Fan R, Ebrahimi M, Czermak P. Anaerobic membrane bioreactor for continous lactic acid fermentation. Membranes. 2017;7(2):26. https://doi.org/10.3390/membranes7020026
33. Meng F, Chae S-R, Drews A, Kraume M, Shin H-S, et al. Recent advances in membrane bioreactors (MBRs): Membrane fouling and membrane material. Water Research. 2009;43(6):1489–1512. https://doi.org/10.1016/j.watres.2008.12.044
34. Xiong Y, Liu Y. Biological control of microbial attachment: A promising alternative for mitigating membrane biofouling. Applied Microbiology and Biotechnology. 2010;86(3):825–837. https://doi.org/10.1007/s00253-010-2463-0
35. Judd SJ. A review of fouling of membrane bioreactor in sewage treatment. Water Science & Technology. 2004; 49(2):229–235. https://doi.org/10.2166/wst.2004.0131
36. van der Marela P, Zwijnenburgb A, Kempermana A, Wessling M, Temmink H, et al. Influence of membrane properties on fouling in submerged membrane bioreactors. Journal of Membrane Science. 2010;348(1–2):66–74. https://doi.org/ 10.1016/j.memsci.2009.10.054
37. Yu H-Y, Hu M-X, Xu Z-K, Wang J-L, Wang S-Yu. Surface modification of polypropylene microporous membranes to improve their antifouling property in MBR: NH3 plasma treatment. Separation and Purification Technology. 2005;45(1):8–15. https://doi.org/10.1016/j.seppur.2005.01.012
38. Kim J-S, Lee C-H, Chang I-S. Effect of pump shear on the performance of a crossflow membrane bioreactor. Water Research. 2001;35(9):2137–2144. https://doi.org/10.1016/S0043-1354(00)00495-4
39. Liu R, Huang X, Sun YF, Qian Y. Hydrodynamic effect on sludge accumulation over membrane surfaces in a submerged membrane bioreactor. Process Biochemistry. 2003;39(2):157–163. https://doi.org/10.1016/S0032-9592(03)00022-0
40. Ognier S, Wisniewski C, Grasmick A. Membrane bioreactor fouling in sub-critical filtration conditions: A local critical flux concept. Journal of Membrane Science 2004;229(1–2):171–177. https://doi.org/10.1016/j.memsci.2003.10.026
41. Pollice A, Brookes A, Jefferson B, Judd S. Sub-critical flux fouling in membrane bioreactors – A review of recent literature. Desalination. 2005;174(3):221–230. https://doi.org/10.1016/j.desal.2004.09.012
42. Cho BD, Fane AG. Fouling transients in nominally sub-critical flux operation of a membrane bioreactor. Journal of Membrane Science. 2002;209(2):391–403. https://doi.org/10.1016/S0376-7388(02)00321-6
43. Meng F, Chae S-R, Drews A, Kraume M, Shin H-S, et al. Recent advances in membrane bioreactors (MBRs): Membrane fouling and membrane material. Water Research. 2009;43(6):1489–1512. https://doi.org/10.1016/j.watres.2008.12.044
44. Palandova RD. Activation methods for baker’s yeast and alternative options. Storage and Processing of Farm Products. 2000;(8):19–22. (In Russ.)
45. Spirin AS, Chetverin AB, Voronin LA, Baranov VI, Alakhov YuB. Protein biosynthesis and prospects of cell-free biotechnology. Bulletin of the USSR Academy of Sciences. 1989;(11):30–38. (In Russ.)