BIOCHEMICAL DISORDER OBSERVED IN A DYSAUTONOMIC: ABOUT A CASE

The autonomic nervous system (SNA) innervates all the organs and ensures the homeostasis of the body, the disorder of the latter causes a pathology called dysautonomy in this work we will try to report the biochemical disorders observed in a dysautonomic patient. This is a 32-year-old patient who went back to the cardiology department of the 3rd military hospital of Laayoune for high Blood pressure and headaches a complete etiological assessment is done and who found hyperlipidemia and hyperglycemia echocardiography is normal, holter tensionel showed high diastolic arterial pressure exploration of the autonomic nervous system gave sympathetic hyperactivity. Biochemical disorders have defined the metabolic syndrome, which is strongly related to morbidity and cardiovascular mortality. The laboratory plays a valuable role in determining the criteria defining metabolic syndrome.

The autonomic nervous system (SNA) innervates all the organs and ensures the homeostasis of the body, the disorder of the latter causes a pathology called dysautonomy; in this work we will try to report the biochemical disorders observed in a dysautonomic patient. This is a 32year-old patient who went back to the cardiology department of the 3rd military hospital of Laayoune for high Blood pressure and headaches; a complete etiological assessment is done and who found hyperlipidemia and hyperglycemia; echocardiography is normal, holter tensionel showed high diastolic arterial pressure; exploration of the autonomic nervous system gave sympathetic hyperactivity. Biochemical disorders have defined the metabolic syndrome, which is strongly related to morbidity and cardiovascular mortality. The laboratory plays a valuable role in determining the criteria defining metabolic syndrome.

Observation:-
Mr M.E aged 32 ,with a BMI of 32 kg/m2 and without a particular history , who presented himself to the cardiology department of the 3rd military hospital of Laayoune for a hypertension: 160/95 mmHg , accompanied by chronic headache, the patient also has other clinical signs: *heaviness of the legs *Orthostatic hypotension *mictional disorder *asthenia *vertigo ISSN: 2320-5407 Int. J. Adv. Res. 8(12), 280-282 281 A biological assessment, transthoracic Doppler echocardiography and holter tensionel are requested . Echocardiography is normal while holter showed an increase in diastolic arterial pressure The standard biological assessment -made on device ABBOTT Architect plus Ci 4100 ( Figure 1)-objectified dyslipidemia and hyperglycemia: *Total cholesterol: 3.10 g/l *LDL cholesterol: 2.3 g/l *Triglycerides: 2 g/l *Fasting glucose: 1.18 g/L A complementary and specific biological assessment looking for plasmatic methoxylated derivatives , aldosterone , rénine; the latter are found without abnormality. Then the patient is referred to a specialized structure for an exploration of the SNA which showed a dysautonomic profile: *central and peripheral alpha and beta sympathetic hyperactivity. *intense vagal response.

Discussion:-
The detection of hyperlipidemia associated with hyperglycemia is part of the clinico-biological criteria that define metabolic syndrome caused by dysautonomy. Metabolic syndrome is a combination of several metabolic and cardiovascular risk factors such as obesity, high blood pressure, glucose intolerance, and hyperlipidemia [3]. The first official definition of this syndrome appeared in 1999 by the World Health Organization (Table 1) [4].
The importance of metabolic syndrome stems from its increasing prevalence worldwide and its association with a remarkable increase in cardiovascular morbidity and mortality [5]. People with metabolic syndrome are five times more likely to develop type 2 diabetes ( if not already) [6] , a three times higher risk of having a myocardial infarction or stroke and a risk of death twice as high [7].
These biochemical disturbances and this metabolic syndrome is explained by the sympathetic hyperactivity observed in this patient or the interest of introducing a treatment that aims to protect the cardiovascular system namely the veinotonics and antihypertensives. 282

Conclusion:-
SNA [8][9] is barely sketched but it is well neglected during medical studies while it regulates practically all the unconscious functions of the body, such as the cardiovascular system; blood pressure and heart rate.and its disruption causes serious metabolic and vascular disorders or the role of the laboratory has unearthed this biochemical dysfunction observed in the metabolic syndrome related to dysautonomy.