UTERINE CANCER: SEX DOMINANT CHARACTER

1. University of Debrecen. 2. Banasthali University. ...................................................................................................................... Manuscript Info Abstract ......................... ........................................................................ Manuscript History Received: 12 February 2020 Final Accepted: 14 March 2020 Published: April 2020 The undermentioned research describes the relationship between uterine cancer and genetic disorder, the research aims at providing a strong relationship using mathematical analysis based on the pedigree of a patient's family, it describes that recurrence of the disease in the family is due to sex linked dominance of the character.


Theory and Methodology:-
Pedigree analysis is the study of inheritable traits in a group of related individuals considering the nature of trait, the onset time and the duration of expression with the degree of effect.This study could categorize the disease into following as shown in the Fig. 1 Fig. 1:-Corresponding Author:-Bharat Kwatra Address:-University of Debrecen.

Autosomal Dominant:
Diseases which are dominant can be expressed even in heterozygous form.To determine whether the trait is dominant is: It is found in every successive generation.Half of the offspring have it.

Autosomal Recessive:
To determine whether the trait is recessive or not following should be considered: Diseased individuals have unaffected parents.1/4 th of progeny is diseased with heterozygote.E.g.: Phenylketonuria, Albinism X-linked recessive: Following are the characteristic features: Affected males have unaffected mothers.Affected female has an father and a carrier or unaffected female.Only females can be the carrier of such disorders.Skipping of generation can be observed.E.g.: Hemophilia, Duchenne muscular dystrophy

X-Linked Dominant:
The characteristic features are: Diseased father has all diseased daughters, but no son will be affected.If a mother is affected, she has 50% chances of passing it to offspring.

E.g.: Hypophosphatemia
Morgan's theory of linkage and recombination: from where we concluded that recombination is inversely proportional to linkage.Pedigree analysis is well known for the study of genetic disorders.Pattern for the occurrence of uterine cancer in the generation of family was studied using pedigree analysis: Study began when a lab report of a 55 years old woman showed uterine endometriosis carcinoma grade 2.The study was conducted in 3 major steps:

Collection of data:
Related medical reports of the patient(B 3 C 1 ) and the medical history of the rest of the related family members were collected.

Establishing relation:
The medical history of the entire family, considering only the uterine cancer was assembled in the form of pedigree which helped us to determine it as a genetic trait.In the pedigree the diseased person is having a non-diseased mother and non-diseased progeny as well which indicates it to be X-linked dominant.

Study:
A brief study was carried out from Mendel's to Morgan's theories based upon which the proving was done.665 Fig. 2:-Pedigree chart of patient's generation suffering with endometrioid carcinoma.

Results and Discussion:-
The pedigree could be predicted as the α (male) is the carrier which happens to be the father of the patient.Since α is carrier and B 3 C 1 is affected (allele value = 1), the 4 th filial, B 3 C 1 D 1 and B 3 C 1 D 2 may or may not be affected.Similarly, B 3 C 2 may or may not be affected (allele value = 0.25) and it is filial B 3 C 2 D 1 may or may not be affected (allele value = 0.25).These character alleles of uterine cancer are shown to be X-linked, keeping the allele of uterine cancer as a newly introduced allele; it should become a fixed allele in generation and must satisfy the microevolution equation.Using the micro-evolution equation given by Bharat Kwatra, et

Conclusions:-
It was concluded from the pedigree analysis and mendelian genetics that the allele responsible for the uterine cancer is x linked and using the micro-evolutionary relations with Morgan law it was mathematically proved to be dominant.Which draws the conclusion to Uterine cancer is a x linked dominant character.