Regular ArticleAbsence of Excretion of the Active Moiety of Bisacodyl and Sodium Picosulfate into Human Breast Milk: an Open-label Parallel-group, Multiple-dose Study in Healthy Lactating Women
References (21)
- et al.
Functional bowel disorders
Gastroenterology
(2006) - et al.
AGA technical review on constipation
Gastroenterology
(2000) - et al.
Bowel patterns among subjects not seeking health care. Use of a questionnaire to identify a population with bowel dysfunction
Gastroenterology
(1982) - et al.
Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features
Am. J. Gastroenterol.
(1999) - et al.
Functional constipation and outlet delay: a population-based study
Gastroenterology
(1993) - et al.
The role of intestinal bacteria in the transformation of sodium picosulfate
Jpn. J. Pharmacol.
(1992) - et al.
Is bisacodyl absorbed at all from suppositories in man?
Int. J. Pharm.
(2000) - et al.
Clinical epidemiology of chronic constipation
J. Clin. Gastroenterol.
(1989) - et al.
Epidemiology of constipation in North America: a systematic review
Am. J. Gastroenterol.
(2004) - et al.
Systematic review on the management of chronic constipation in North America
Am. J. Gastroenterol.
(2005)
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2015, Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment: Third EditionGastrointestinal drugs
2014, Side Effects of Drugs AnnualCitation Excerpt :The sodium phosphate preparation caused more nausea, significantly lower serum calcium and phosphate concentrations, and a higher pulse rate. Breast feeding Bisacodyl and sodium picosulfate have a common active metabolite, bis-(para-hydroxyphenyl)-pyridyl-2-methane (BHPM) [93c]. After administration of bisacodyl and sodium picosulfate to two groups of 8 healthy lactating women who had stopped breast feeding BHPM could not be detected in breast milk, despite its appearance in plasma within 3–4 hours after bisacodyl and 4–5 hours after sodium picosulfate, with Cmax at 5 and 9 hours respectively.
High-sensitivity liquid chromatography-tandem mass spectrometry method for the simultaneous determination of sodium picosulfate and its three major metabolites in human plasma
2013, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :No study concerning the individual or simultaneous determination of PICO and its metabolites in a biological matrix has yet been reported. Possibly constrained by assay sensitivity, the published procedures for the toxicological screening of PICO only determine the total concentration of BHPM in a biological matrix after enzymatic cleavage of its conjugates [7,8]. A human metabolism study carried out in our laboratory revealed that the major metabolite of PICO in human plasma is M1.
The use of sodium thiosulfate in the treatment of hemorrhoids
2023, Ambulatornaya Khirurgiya
This study was sponsored by Boehringer Ingelheim, Germany.