The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Original Article
Data on long-term survival of the NOD/Shi-scid IL-2Rγnull (NOG) mouse in two facilities
Yuji YamashitaTamio SatoKaori NoishikiKinji KobayashiAsako UchiyamaHiroyuki IzumiTakashi TamuraMasayuki ShikamuraYu OinishiMiho SaitoShin Kawamata
Author information
JOURNAL FREE ACCESS FULL-TEXT HTML
Supplementary material

2021 Volume 46 Issue 10 Pages 453-469

Details
Abstract

The objective of this study was to investigate an appropriate observation period for an evaluation of tumorigenicity in NOD/Shi-scid IL-2 Rγnull (NOG) mice. At SNBL, 19 male and 19 female NOG mice were observed the general condition from 7 weeks old up to 68 weeks old and at FBRI, 7 male and 16 female NOG mice were observed the general condition throughout the lifespan from 7 weeks old. The survival rate started to decline rapidly around 54 to 56 weeks of age in both facilities without a facility difference. Based on these survival data, it seems reasonable to terminate a tumorigenicity study at 52 weeks of age.

Content from these authors
© 2021 The Japanese Society of Toxicology
Previous article Next article
feedback
Top