A Study of Histopathological Spectrum of Ovarian Neoplastic and Non-Neoplastic Lesions at Teaching Hospital, Ahmedabad

  • Piyush Ashokbhai Patel Department of Pathology, GMERS Medical College and Sola Civil Hospital, Ahmedabad, India
  • Deval Narendrakumar Patel Department of Pathology, GMERS Medical College and Sola Civil Hospital, Ahmedabad, India
  • Mona Manubhai Patel Department of Pathology, GMERS Medical College and Sola Civil Hospital, Ahmedabad, India
  • Jignasa Nathalal Bhalodia Department of Pathology, GMERS Medical College and Sola Civil Hospital, Ahmedabad, India
DOI: https://doi.org/10.21276/APALM.2856
Keywords: Ovarian lesion, Surface epithelial tumor, Germ cell tumor

Abstract

Background: Ovarian carcinoma is one of the most common gynecologic cancers that ranks third after cervical and uterine cancer. ovarian lesions are neoplastic and non neoplastic and many neoplastic lesions are asymptomatic and possess great challenge to the gynecological oncologist. Aims & Objectives: To analyze frequency, age distribution and histopathological spectrum of ovarian lesions at teaching hospital, Ahmedabad. Materials & Method: This study was undertaken between period of 1st January 2018 to 29th February 2020 at Department of Pathology, GMERS Medical college, sola, Ahmedabad. H and E stained slides were examined by light microscopy and histopathological type of lesions were classified according to World Health Organization (WHO) classification -2014. Results: There were total 182 cases of ovarian lesions. 56(30.76%) cases are neoplastic, among them only 6(10.71%) were malignant. Surface epithelial tumor (n=27 cases, 48.21%) were most common neoplastic lesion while sex cord stromal tumor (n=8 cases,14.29%) were least common. Most common age group affected for neoplastic lesions was 31-40 years. Conclusion: We found that ovarian lesions affect wide variation of age starting from 11 years young patient to 65 years old patients. Non neoplastic lesions were almost double in prevalence than neoplastic lesions. Histopathological analysis according to WHO classification reveal that surface epithelial tumors and germ cell tumors were forms the majority of neoplastic lesions.

References

1. Malli M, Vyas B, Gupta S, Desai H. A histological study of ovarian tumors in different age groups. International Journal of Medical Science and Public Health. 2014 Mar 1;3(3):338-42.
2. Kanthikar SN, Dravid NV, Deore PN, Nikumbh DB, Suryawanshi KH. Clinico-histopathological analysis of neoplastic and non-neoplastic lesions of the ovary: a 3-year prospective study in Dhule, North Maharashtra, India. Journal of clinical and diagnostic research: JCDR. 2014 Aug;8(8):FC04.
3. Momenimovahed Z, Tiznobaik A, Taheri S, Salehiniya H. Ovarian cancer in the world: epidemiology and risk factors. International journal of women's health. 2019;11:287.
4. Thirukumar M, Ahilan S. Histopathological pattern of ovarian lesions: a Hospital based study in Batticaloa, Sri Lanka. Journal of Diagnostic Pathology. 2018;13(1):16-21.
5. WHO classification of ovarian neoplasms. Pathology Outlines.com website. http://www.pathologyoutlines.com/topic/ovary tumorwhoclassif.html. Accessed January 30th, 2019.
6. Shah Neerja, Raval Nisha G , Joshi Jayesh R, Agnihotri Ashok S histopathological spectrum of ovarian neoplasms- a 14 year study; Pathology and laboratory medicine 2016,vol 2, issue 8.
7. Sawant A, Mahajan S. Histopathological study of ovarian lesions at a tertiary health care institute. MVP Journal of Medical Science. 2017 May 22;4(1):26-9.
8. Kurman RJ, Norris HJ. Malignant germ cell tumours of the ovary. Hum Pathol.1977; 8(5):551–64. Available from: https://doi.org/10.1016/S0046-8177(77)80115-9.
9. Pilli GS, Suneeta KP, Dhaded AV, Yenni VV. Ovarian tumours: a study of 282 cases. Journal of the Indian Medical Association. 2002 Jul;100(7):420-3.
10. Tushar, Kar & Kar, Asaranti & Kathagola, & Mangalabag, Cuttack. (2005). Intra-operative cytology of ovarian tumours. Journal of Obstetrics and Gynecology of India. 55. 345-349.
11. Thakkar NN, Shah SN. Histopathological study of ovarian lesions. Int J Sci Res. 2015;4(10):1745-9.
12. Gupta N, Bisht D, Agarwal AK, Sharma VK. Retrospective and prospective study of ovarian tumours and tumour-like lesions. Indian journal of pathology & microbiology. 2007 Jul;50(3):525-7.
13. Mankar DV, Jain GK. Histopathological profile of ovarian tumours: A twelve year institutional experience. Muller J Med Sci Res. 2015;6(2):107-1.
14. Mondal SK, Banyopadhyay R, Nag DR, Roychowdhury S, Mondal PK, Sinha SK. Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India. Journal of cancer research and therapeutics. 2011 Oct 1;7(4):433.
15. Shadab S, Tadayon T. Histopathological diagnosis of ovarian mass. Journal of Pathology of Nepal. 2018 Apr 3;8(1):1261-4.
16. Pradhan A, Sinha AK, Upreti D. Histopathological patterns of ovarian tumors at BPKIHS. Health Renaissance. 2012 Jul 28;10(2):87-97.
17. Danish F, Khanzada MS, Mirza T, Aziz S, Naz E, Khan MN. Histomorphological spectrum of ovarian tumors with immunohistochemical analysis of poorly or undifferentiated malignancies. Gomal Journal of Medical Sciences. 2012 Dec 31;10(2).
18. Chanu SM, Dey B, Raphael V, Panda S, Khonglah Y. Clinicopathological profile of ovarian cysts in a tertiary care hospital. Int J Reprod Contracept Obstet Gynecol. 2017;6:4642-5.
19. Greene MH, Clark JW, Blayney DW. The epidemiology of ovarian cancer. InSeminars in oncology 1984 Sep (Vol. 11, No. 3, pp. 209-226).
20. Harlow BL, Weiss NS, Roth GJ, Chu J, Daling JR: Case-control study of borderline ovarian tumors. Reproductive history and exposure to exogenous female hormones. Cancer Res 1988; 48:5849-5852.
21. Richardson GS, Scully RE, Nikrui N, Nelson JH: Common epithelial cancer of the ovary. N Engl J Med 1985; 312:415-424.474–483
22. Weiss NS: Measuring the separate effects of low parity and its antecedents on the incidence of ovarian cancer. Am J Epidemiol 1988; 128:451-455.
23. Agarwal D, Kaur S, Agarwal R, Gathwal M. Histopathological analysis of neoplastic lesions of the ovary: a 5-year retrospective study at tertiary health care centre. International Journal of Contemporary Medical Research. 2018;5(5):E14-7.
Published
2020-10-29
Issue
Vol 7 No 10 (2020)
Section
Original Article

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).