A peculiar case of psychosis

● Background: Psychosis in pregnancy is rare and could be life-threatening. It requires prompt evaluation and proper management accordingly. Anti-N-methyl-d-aspartate receptor (anti-NMDAr) encephalitis following herpes simplex virus (HSV) infection is a rare cause of psychosis during pregnancy. ● Case presentation: A 20 year old woman at 18 weeks gestation presented with agitation and a 3-day history of hallucinations. She had a prior hospitalization for HSV encephalitis six weeks before. Her laboratory workup was unremarkable except for positive anti-NMDAr antibodies in the CSF. The patient was treated with high dose corticosteroids and plasmapheresis and she was discharged two weeks later fully recovered. ● Conclusions: Anti-NMDAr encephalitis can be the culprit behind a new-onset of psychosis in pregnancy. Early diagnosis and treatment are crucial.


Abstract
• Background: Psychosis in pregnancy is rare and could be life-threatening. It requires prompt evaluation and proper management accordingly. Anti-N-methyl-d-aspartate receptor (anti-NMDAr) encephalitis following herpes simplex virus (HSV) infection is a rare cause of psychosis during pregnancy.
• Case presentation: A 20 year old woman at 18 weeks gestation presented with agitation and a 3-day history of hallucinations. She had a prior hospitalization for HSV encephalitis six weeks before. Her laboratory workup was unremarkable except for positive anti-NMDAr antibodies in the CSF. The patient was treated with high dose corticosteroids and plasmapheresis and she was discharged two weeks later fully recovered.
• Conclusions: Anti-NMDAr encephalitis can be the culprit behind a new-onset of psychosis in pregnancy. Early diagnosis and treatment are crucial.

Background
Anti-N-methyl-d-aspartate receptor (anti-NMDAr) encephalitis is the most common autoimmune encephalitis. It was rst reported in 2005 and has been thoroughly studied since then. [1] It is postulated that autoantibodies target the Nu1 subunit of NMDA receptor, decreasing its activity, and leading to symptoms of anti-NMDAr encephalitis. Anti-NMDAr encephalitis presentation often comprises prodromal viral-like symptoms that progress into psychiatric symptoms, confusion, memory disturbances, seizures, and movement disorders.
The two known triggers of anti-NMDAr encephalitis are tumors and infectious agents, particularly herpes simplex virus (HSV).
Anti-NMDAr encephalitis is rare in pregnancy, and its psychiatric features resemble many primary mental disorders that could present with acute psychosis.
We report the case of a young pregnant woman presenting with an acute psychotic episode three weeks after recovering from HSV encephalitis. Her acute symptoms were attributed to anti-NMDAr encephalitis following HSV-1 infection. We believe that this report sheds some light on this recently-described disease and encourages clinicians to consider this diagnosis when evaluating acute episodes of psychosis in pregnant patients.

Case Presentation
A 20 year-old female gravida 2 para 1 at 22 weeks gestation, presented to our emergency room with agitation. She experienced 5 days of visual hallucinations according to her family. They denied any fever, headache, or vomiting. They also denied any recent history of head trauma. The patient does not use tobacco, alcohol, or illicit drugs. She had a normal prenatal course during the rst trimester.
Six weeks earlier, she presented to our institution with a 3-day history of severe headache, fever, and vomiting accompanied by behavioural changes for two days. She was diagnosed with HSV-1 encephalitis based on positive HSV1 PCR in the cerebrospinal uid and characteristic brain MRI ndings.
She was treated with acyclovir for 3 weeks and was symptom-free at discharge.
Based on the patient's history and current presentation, a CSF sample was obtained to rule out HSV encephalitis recurrence. Cerebrospinal uid was within normal limits and HSV1 PCR was negative.
Laboratory panels including liver, renal, and thyroid function tests, electrolytes concentrations, full blood count and coagulation markers were all within normal limits. Vitamin B12 and folic acid levels were also normal.
An abdominal ultrasound was performed to rule out ovarian teratoma, which is known to cause anti-NMDAr encephalitis. It showed a 22-week-old viable fetus and no pelvic masses were seen.
Treatment with high dose corticosteroid was started and plasmapheresis was performed. The patient had remarkable improvement within two weeks of admission. She was discharged fully recovered.

Discussion
When evaluating a patient with acute altered mental status or psychosis, the primary goal is to differentiate between an encephalopathy and a psychiatric disorder; such as schizophrenia or bipolar disorder. [2] It is very unlikely for a rst psychotic episode of a psychiatric disorder to occur during pregnancy. [ 3] A new-onset of psychosis in a pregnant woman should stimulate a thorough workup for an underlying medical or pharmacologic etiology, particularly when it is accompanied by clear disorientation, visual or tactile hallucinations, uctuations in the level of consciousness, or evident neurologic symptoms. [2] Whereas psychotic episodes of psychiatric disorders present with delusions, hallucinations, thought disorganization, and agitation. [4] There is limited data on the incidence of new-onset psychotic episodes during pregnancy. According to Paffenbarger et al., the overall rate of mental illness during pregnancy was 5 per 10.000 live births. [3] However, psychotic episodes of underlying psychiatric disease may relapse or reactivate during pregnancy. [2,3] Psychosis can be the presenting symptom of many medical illnesses and neurologic conditions, such as delirium, endocrine disorders (thyroid and adrenal dysfunction), hepatic and uremic encephalopathy, infectious disease, in ammatory and demyelinating disorders, metabolic disorders, neurological and neurodegenerative diseases, and vitamin de ciency.
Our patient had no history of endocrine, renal, or hepatic disease and her liver, and renal function tests were normal at the current presentation. She had no history of alcohol abuse and she had no diagnosed psychiatric disease.
However, she had a history of HSV encephalitis six weeks earlier and was treated with acyclovir until complete resolution. Based upon her current symptoms and history, it was presumed that she was either undergoing a recurrence of the viral encephalitis or an autoimmune encephalitis following the viral disease.
Her CSF sample analysis con rmed the latter and HSV-induced anti-NMDAr encephalitis was diagnosed.
To our knowledge, this is the rst reported case in Syria of anti-NMDAr encephalitis following HSV infection in a pregnant patient.
Anti-NMDAr encephalitis is rarely reported in pregnancy and when it occurs, it is di cult to delineate it from other neuropsychiatric disorders.
Rare disorders as such can only be diagnosed when thought of; therefore we highlight the importance of taking a detailed patient history when evaluating psychosis in a pregnant woman.
The clinical presentation of anti-NMDAr encephalitis comprises a viral-like illness that later progresses to a constellation of symptoms including, but not limited to, psychiatric manifestations, seizures, decreased consciousness level, dyskinesias, language defect, and autonomic dysfunction.
Anti-NMDAr is associated with the presence of underlying tumors, namely ovarian teratomas containing nervous tissue. [5] In a cohort study conducted by Titulaer et al. it was found that 50% of anti-NMDAr female patients had ovarian teratomas.
[6] However, in patients older than 45 years, anti-NMDAr encephalitis is rarely accompanied by tumors, and in those cases, carcinomas are more commonly detected leading to a less favourable outcome. [7] Anti-NMDAr encephalitis is also associated with preceding herpes simplex encephalitis. Studies have shown that 20-30% of patients with prior HSV encephalitis who present with a relapse of symptoms not related to HSV relapse do have anti-NMDAr antibodies detected in their CSF. Anti-NMDAr IgG antibodies can cross the placenta and have been reported to be detectable in the serum of babies born to affected mothers during pregnancy. However, it is still unclear whether these