The ability to perform optimally under pressure is critical across many occupations, including the military, first responders, and competitive sport, and depends on a range of cognitive factors. How common these key performance factors are across application domains remains unclear. The current study sought to integrate existing knowledge in the performance field in the form of a transdisciplinary expert consensus on the cognitive mechanisms that underlie performance under pressure. International experts were recruited from four performance domains (i. Defence; ii. Competitive Sport; iii. Civilian High-stakes; and iv. Performance Neuroscience). Experts rated constructs from the Research Domain Criteria (RDoC) framework (in addition to several expert-suggested constructs) across successive rounds, until all constructs reached consensus for inclusion or were eliminated. Finally, included constructs were ranked for their relative importance. Sixty-eight experts completed the first Delphi round, with 94% of experts retained by the end of the Delphi process. Seven of the ten constructs that reached transdisciplinary consensus came from the Cognitive Systems domain including: 1) Attention; 2) Cognitive Control—Goal Selection, Updating, Representation & Maintenance; 3) Cognitive Control—Performance Monitoring; 4) Cognitive Control—Response Selection & Inhibition/Suppression; 5) Working memory—Flexible Updating; 6) Working memory—Active Maintenance; and 7) Working memory—Interference Control. Other constructs that reached transdisciplinary consensus were Self-knowledge, Arousal, and Shifting (an expert-suggested construct). Our results identify a set of transdisciplinary neuroscience-informed constructs, validated through Delphi consensus. This expert consensus is critical to standardising cognitive assessment and informing mechanism-targeted interventions in the broader field of human performance optimisation.