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Phenylboronic Acid-based 19F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change

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Abstract

Herein, we report on a new 19F MRI probe for the detection and imaging of H2O2. Our designed 2-fluorophenylboronic acid-based 19F probe promptly reacted with H2O2 to produce 2-fluorophenol via boronic acid oxidation. The accompanying 19F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H2O2 by 19F chemical-shift-selective MRI.

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Acknowledgments

We thank Dr. T. Ishimoto of Kyushu University for discussions and Prof. T. Matsuda (Kyoto University) for their help in the 19F MRI experiments. This work was supported by the Funding Program for Next Generation World-Leading Researchers (NEXT), partly by Grants-in-Aid No. 25620135 (H. N.) from JSPS, and partly by CREST, Japan Science and Technology Agency (JST). T. A. thanks JSPS for a fellowship.

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Authors and Affiliations

  1. INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi, Fukuoka, 819-0395, Japan

    Hiroshi Nonaka, Qi An, Tomohiro Doura, Akira Tsuchiya & Shinsuke Sando

  2. Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Fuminori Sugihara & Yoshichika Yoshioka

Authors
  1. Hiroshi Nonaka
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  2. Qi An
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  3. Fuminori Sugihara
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  4. Tomohiro Doura
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  5. Akira Tsuchiya
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  6. Yoshichika Yoshioka
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  7. Shinsuke Sando
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Corresponding author

Correspondence to Shinsuke Sando.

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Nonaka, H., An, Q., Sugihara, F. et al. Phenylboronic Acid-based 19F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change. ANAL. SCI. 31, 331–335 (2015). https://doi.org/10.2116/analsci.31.331

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  • DOI: https://doi.org/10.2116/analsci.31.331

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