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Alternative Plugs Flow Liquid Chromatography (APFLC)/EI-MS System Using a T-shaped Flow Path

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Abstract

The vapor condensation method can be used for forming an alternative flow of liquid masses using a single solvent for alternative plugs flow liquid chromatography (APFLC), described in our previous paper. APFLC is more effective when adopting a T-shaped flow path and aqueous-organic solvents with a liquid-to-gas volume ratio (bulk fraction; ß) ranging between 0.0006 and 0.004 in an open tubular GC capillary column at below 70°C. High-density plugs flow by a T-shaped flow path leads to extremely high resolution. Alternative plugs flow is formed when the liquid contact angle to the solid phase is above 75°. An aqueous mixture of the usual HPLC solvent can be readily used for APFLC. An EI-mass spectrum is obtained that is comparable with that in the NIST library, except for the DMF mixture medium. Due to low-pressure loss properties in the column, the system does not require a high-pressure liquid pump. Solid hydrocarbon resin with a contact angle to water of between 75° and 79°, such as polystyrene and olefinic polymers, is anticipated to be applicable to APFLC and hydro-membrane gas chromatography (HMGC) by a consideration of their surface tensions.

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Authors and Affiliations

  1. Infra-red Spectroscopy Analytical Laboratory, 3-3-13 Chuo, Ebina, Kanagawa, 243-0432, Japan

    Isao Tanikawa

  2. Corporate Research & Development, Toyo Seikan Group, 22-4 Okazawa, Hodogaya, Yokohama, Kanagawa, 240-0062, Japan

    Miwako Konuma & Hiroko Hosono

  3. Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan

    Hiroshi Nakamura

Authors
  1. Isao Tanikawa
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  2. Miwako Konuma
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  3. Hiroko Hosono
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  4. Hiroshi Nakamura
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Correspondence to Isao Tanikawa.

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Tanikawa, I., Konuma, M., Hosono, H. et al. Alternative Plugs Flow Liquid Chromatography (APFLC)/EI-MS System Using a T-shaped Flow Path. ANAL. SCI. 27, 95–99 (2011). https://doi.org/10.2116/analsci.27.95

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  • DOI: https://doi.org/10.2116/analsci.27.95

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