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Fluorescent probe visualization for selective detection of cuprous ion

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Abstract

Cuprous ion is an essential element for human life activities. However, excessive cuprous can cause dysfunction of the human body system. To help explain this evolving biology, we report a fluorescent probe for detecting unstable Cu(I). Cu(I) undergoes a metal complexation reaction with the sulfur element in the probe, resulting in a photoelectron transfer (PET) effect. The probe fluorescence is greatly suppressed, and rapid and selective visual detection of Cu(I) in the inorganic environment is realized. There is also a good linear relationship between the probe fluorescence intensity and the Cu(I) concentration (R2 = 0.992), which can realize the quantitative detection of Cu(I). When the probe concentration is 0.1 μM, the detection limit is 15 nM, and the detection limit of the visual method is as low as 0.1 μM. This work provides a valuable starting point for real-time monitoring of the Cu(I) concentration in a human anaerobic environment based on active probes.

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References

  1. J. Chayen, Cell. Biochem. Fun. 13(2), 153 (1995)

    Article  CAS  Google Scholar 

  2. P.G. Ridge, Y. Zhang, V.N. Gladyshev, PLoS ONE 3, 1 (2008)

    Article  Google Scholar 

  3. E.L. Que, D.W. Domaille, C.J. Chang, Chem. Rev. 108(5), 1517 (2008)

    Article  CAS  Google Scholar 

  4. A.K. Boal, A.C. Rosenzweig, Chem. Rev. 109(10), 4760 (2009)

    Article  CAS  Google Scholar 

  5. L. Band, I. Bertini, S. Ciofi-Baffoni, T. Kozyreva, K. Zovo, P. Palumaa, Nature 465, 645 (2010)

    Article  Google Scholar 

  6. C.J. Chang, Nat. Chem. Biol. 11(10), 744 (2015)

    Article  CAS  Google Scholar 

  7. S.C. Dodani, D.W. Domaille, C.I. Nam, E.W. Miller, L.A. Finney, S. Vogt, C.J. Chang, Proc. Natl. Acad. Sci. USA. 108(15), 5980 (2011)

    Article  CAS  Google Scholar 

  8. R.H. Crabtree, J. Inorg. Nucl. Chem. 40, 1453 (1978)

    Article  CAS  Google Scholar 

  9. X. Duan, E. Block, Z. Li, T. Connelly, J. Zhang, Z. Huang, X. Su, Y. Pan, L. Wu, Q. Chi, Proc. Natl. Acad. Sci. USA. 109(9), 3492 (2012)

    Article  CAS  Google Scholar 

  10. L. Krishnamoorthy, J.A. Cotruvo, J. Chan, H. Kaluarachchi, C.J. Chang, Nat. Chem. Biol. 12(8), 586 (2016)

    Article  CAS  Google Scholar 

  11. T. Finkel, M. Serrano, M.A. Blasco, Nature 448(7155), 767 (2007)

    Article  CAS  Google Scholar 

  12. K.J. Barnham, A.I. Bush, Chem. Soc. Rev. 43(19), 6727 (2014)

    Article  CAS  Google Scholar 

  13. S.G. Kaler, Nat. Rev. Neurol. 7(1), 15 (2011)

    Article  CAS  Google Scholar 

  14. J.L. Burkhead, L.W. Gray, S. Lutsenko, Biometals 24(3), 455 (2011)

    Article  CAS  Google Scholar 

  15. U. Merle, M. Schaefer, P. Ferenci, W. Stremmel, Gut 56(1), 115 (2007)

    Article  CAS  Google Scholar 

  16. A.C. Joseph, T.A. Allegra, M.R. Karla, J.C. Christopher, Chem. Soc. Rev. 44(13), 4400 (2015)

    Article  Google Scholar 

  17. K.P. Carter, A.M. Young, A.E. Palmer, Chem. Rev. 114, 4564 (2014)

    Article  CAS  Google Scholar 

  18. A.T. Aron, K.M. Ramos-Torres, J.A. Cotruvo, C.J. Chang, Acc. Chem. Res. 48(8), 2434 (2015)

    Article  CAS  Google Scholar 

  19. C.J. Fahrni, Curr. Opin. Chem. Biol. 17(4), 656 (2013)

    Article  CAS  Google Scholar 

  20. M.C. Heffern, H.M. Park, H.Y. Au-Yeung, D. Van, C.M. Ackerman, A. Stahl, C.J. Chang, Proc. Natl. Acad. Sci. USA. 113(50), 14219 (2016)

    Article  CAS  Google Scholar 

  21. E.L. Que, C.J. Chang, Chem. Soc. Rev. 39(1), 51 (2009)

    Article  Google Scholar 

  22. E.L. Que, C.J. Chang, J. Am. Chem. Soc. 128(50), 15942 (2006)

    Article  CAS  Google Scholar 

  23. E.L. Que, E. Gianolio, S.L. Baker, A.P. Wong, S. Aime, C.J. Chang, J. Am. Chem. Soc. 131(24), 8527 (2009)

    Article  CAS  Google Scholar 

  24. S. Park, H.J. Kim, J. Hypertens. 9(33), 4473 (2012)

    Google Scholar 

  25. I. Tsujikawa, E. Kanda, The 573rd report of the Research Institute for Iron, Steel and Other Metals, P420 (Tohoku University, Japan, 1950)

    Google Scholar 

  26. W. Zeng, X. Yang, X. Chen, Y. Yan, Eur. Polym. J. 61, 309 (2014)

    Article  CAS  Google Scholar 

  27. Y. Fu, C. Liu, S. Pu, Sens. Actuators B 239, 295 (2017)

    Article  CAS  Google Scholar 

  28. F. Ma, M. Sun, K. Zhang, Y. Zhang, H. Zhu, L. Wu, D. Huang, S. Wang, RSC Adv. 4(104), 59961 (2014)

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The work was financially supported by the National Key Research and Development Program of China (2017YFA02070000), the National Natural Science Foundation of China (21775042).

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Authors and Affiliations

  1. Guangdong Provincial Key Laboratory of Petrochemical Pollution Process and Control, School of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming, 525000, Guangdong, China

    Ranhao Yin & Suhua Wang

  2. School of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, China

    Long Yu, Pengchen Su, Guoqiang Liu & Hongwei Ge

Authors
  1. Ranhao Yin
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  2. Long Yu
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  3. Pengchen Su
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  4. Guoqiang Liu
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  5. Hongwei Ge
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  6. Suhua Wang
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Corresponding author

Correspondence to Suhua Wang.

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Advanced Publication Released Online by J-STAGE September 10, 2021.

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Yin, R., Yu, L., Su, P. et al. Fluorescent probe visualization for selective detection of cuprous ion. ANAL. SCI. 38, 145–150 (2022). https://doi.org/10.2116/analsci.21P218

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