Skip to main content
SpringerLink
Log in

Characterization of pressure-driven water flows in nanofluidic channels by mass flowmetry

  • Original Paper
  • Published:
Analytical Sciences Aims and scope Submit manuscript

Abstract

With developments in analytical devices promoted by nanofluidics, estimation of the flow rate in a nanochannel has become important to calculate volumes of samples and reagents in chemical processing. However, measurement of the flow rate in nanospaces remains challenging. In the present study, a mass flowmetry system was developed, and the flow rate of water by pressure-driven flow in a fused-silica nanochannel was successfully measured in picoliters per second. We revealed that the water flow rate is dependent on the viscosity significantly increased in a square nanochannel with 102 nm width and depth (3.6 times higher than the bulk viscosity for a representative channel size of 190 nm) and slightly increased in a plate nanochannel with micrometer-scale width and 102 nm depth (1.3 times higher for that of 234 nm), because of dominant surface effects. The developed method and results obtained will greatly contribute to nanofluidics and other related fields.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. X. Ou, P. Chen, B.-F. Liu, Anal. Sci. 35, 609 (2016)

    Article  Google Scholar 

  2. L.F. Giraldo, B.L. López, L. Pérez, S. Urrego, L. Sierra, M. Mesa, Macromol. Symp. 258, 129 (2007)

    Article  CAS  Google Scholar 

  3. H. Shimizu, K. Toyoda, K. Mawatari, S. Terabe, T. Kitamori, Anal. Chem. 91, 3009 (2019)

    Article  CAS  Google Scholar 

  4. N. Varongchayakul, J. Song, A. Meller, M.W. Grinstaff, Chem. Soc. Rev. 47, 8512 (2018)

    Article  CAS  Google Scholar 

  5. B.R. Cipriany, P.J. Murphy, J.A. Hagarman, A. Cerf, D. Latulippe, S.L. Levy, J.J. Benítez, C.P. Tan, J. Topolancik, P.D. Soloway, H.G. Craighead, Proc. Natl. Acad. Sci. USA 109, 8477 (2012)

    Article  CAS  Google Scholar 

  6. T. Nakao, Y. Kazoe, E. Mori, K. Morikawa, T. Fukasawa, A. Yoshizaki, T. Kitamori, Analyst 144, 7200 (2019)

    Article  CAS  Google Scholar 

  7. G.K. Lockwood, S.H. Garofalini, J. Phys. Chem. C 118, 29750 (2014)

    Article  CAS  Google Scholar 

  8. R. Zhou, C. Sun, B. Bai, J. Chem. Phys. 154, 074709 (2021)

    Article  CAS  Google Scholar 

  9. A. Hibara, T. Saito, H.B. Kim, M. Tokeshi, T. Ooi, M. Nakao, T. Kitamori, Anal. Chem. 74, 6170 (2002)

    Article  CAS  Google Scholar 

  10. L. Li, Y. Kazoe, K. Mawatari, Y. Sugii, T. Kitamori, J. Phys. Chem. Lett. 3, 2447 (2012)

    Article  CAS  Google Scholar 

  11. K. Morikawa, Y. Kazoe, K. Mawatari, T. Tsukahara, T. Kitamori, Anal. Chem. 87, 1475 (2015)

    Article  CAS  Google Scholar 

  12. H. Chinen, K. Mawatari, Y. Pihosh, K. Morikawa, Y. Kazoe, T. Kitamori, Angew. Chem. Int. Ed. 51, 3573 (2012)

    Article  CAS  Google Scholar 

  13. T. Tsukahara, A. Hibara, Y. Ikeda, T. Kitamori, Angew. Chem. Int. Ed. 46, 1180 (2007)

    Article  CAS  Google Scholar 

  14. N.R. Tas, J. Haneveld, H.V. Jansen, M. Elwenspoek, A. van den Berg, Appl. Phys. Lett. 85, 3274 (2004)

    Article  CAS  Google Scholar 

  15. S. Liu, Q. Pu, L. Gao, C. Korzeniewski, C. Matzke, Nano Lett. 5, 1389 (2005)

    Article  CAS  Google Scholar 

  16. K. Morikawa, K. Mawatari, M. Kato, T. Tsukahara, T. Kitamori, Lab. Chip 10, 871 (2010)

    Article  CAS  Google Scholar 

  17. M. Whitby, L. Cagnon, M. Thanou, N. Quirke, Nano Lett. 8, 2632 (2008)

    Article  CAS  Google Scholar 

  18. R. Ishibashi, K. Mawatari, K. Takahashi, T. Kitamori, J. Chromatogr. A 1228, 51 (2012)

    Article  CAS  Google Scholar 

  19. J.P. Brody, P. Yager, R.E. Goldstein, R.H. Austin, Biophys. J. 71, 3430 (1996)

    Article  CAS  Google Scholar 

  20. J. Kestin, M. Sokolov, W.A. Wakeham, J. Phys. Chem. Ref. Data 7, 941 (1978)

    Article  CAS  Google Scholar 

  21. M. Wang, C.-C. Chang, R.-Y. Yang, J. Chem. Phys. 132, 024701 (2010)

    Article  Google Scholar 

  22. S.I. Kim, S.J. Kim, Microfluid. Nanofluid. 22, 12 (2018)

    Article  Google Scholar 

  23. Y. Kazoe, K. Mawatari, Y. Sugii, T. Kitamori, Anal. Chem. 83, 8152 (2011)

    Article  CAS  Google Scholar 

  24. R.F. Probstein, Physicochemical Hydrodynamics (Wiley, New York, 1994)

    Book  Google Scholar 

  25. Q. Xie, F. Xin, H.G. Park, C. Duan, Nanoscale 8, 19527 (2016)

    Article  CAS  Google Scholar 

  26. Q. Xie, M.A. Alibakhshi, S. Jiao, Z. Xu, M. Hempel, J. Kong, H.G. Park, C. Duan, Nat. Nanotech. 13, 238 (2018)

    Article  CAS  Google Scholar 

  27. Y. Kazoe, K. Mawatari, L. Li, H. Emon, N. Miyawaki, H. Chinen, K. Morikawa, A. Yoshizaki, P.S. Dittrich, T. Kitamori, J. Phys. Chem. Lett. 11, 5776 (2020)

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by a Kakenhi Grant-in-Aid (No. JP21000007) from the Japan Society for the Promotion of Science (JSPS). Fabrication facilities were provided in part by the Academic Consortium for Nano and Micro Fabrication from four universities (The University of Tokyo, Tokyo Institute of Technology, Keio University and Waseda University, Japan).

Author information

Authors and Affiliations

  1. Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8656, Japan

    Yutaka Kazoe, Kyojiro Morikawa, Kazuma Mawatari & Takehiko Kitamori

  2. Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8656, Japan

    Sho Kubori, Kazuma Mawatari & Takehiko Kitamori

Authors
  1. Yutaka Kazoe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sho Kubori
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kyojiro Morikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kazuma Mawatari
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takehiko Kitamori
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yutaka Kazoe or Takehiko Kitamori.

Additional information

Advanced Publication Released Online by JSTAGE July 30, 2021.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kazoe, Y., Kubori, S., Morikawa, K. et al. Characterization of pressure-driven water flows in nanofluidic channels by mass flowmetry. ANAL. SCI. 38, 281–287 (2022). https://doi.org/10.2116/analsci.21P198

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2116/analsci.21P198

Keywords

Search

Navigation