Skip to main content
SpringerLink
Log in

Development of Highly Sensitive Analysis Method for Histamine and Metabolites in Pregnant Women’s Fingernail by UPLC-ESI-MS

  • Published:
Analytical Sciences Aims and scope Submit manuscript

Abstract

In this study, a highly sensitive analysis method for the rapid detection of histamine (HA), imidazole-4-acetic acid (IAA) and 1-methylhistamine (MHA) in pregnant women’s fingernails was developed using the ultra-performance liquid chromatography (UPLC) coupled with electrospray ionization tandem mass spectrometry (ESI-MS/MS). HA and MHA were connected with 4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (DBD-F) as the derivation reagent for the first time. IAA was derivatized with 4-(N,N-dimethylaminosulfonyl)-7-piperazino-2,1,3-benzoxadiazole (DBDPZ) successfully. The derivative mixtures were simultaneously separated within 8 min on an ACQUITY UPLCTM BEH C18 column (1.7 μm, 100 × 2.1 mm i.d.) by isocratic elution using a mixture of 20 mM HCOONH4 and CH3CN (82:18) as the mobile phase, and sensitively detected by selected reaction monitoring (SRM). The quantitative analysis of HA, IAA, and MHA are performed by SRM using the fragmentation transitions of m/z 337.2 → 292.1, 420.6 → 375.1 and 351.2 → 306.0 under the positive ESI mode. The calibration curves for HA, IAA and MHA are presented herein, and their correlation coefficient were found to be above 0.9998, the measured detection limit for derivatized histamine and metabolites ranged from 0.06 to 0.15 fmol, and the relative standard derivation of intra-day and inter-day assays was 6.3%. Furthermore, the mean recoveries (%) of the standards added to human fingernails were in the range of 90.2–100.5%. The validated method was successfully applied to analyze human fingernail samples from three pregnant women and three healthy non-pregnant women. To the best of our knowledge, this report about the detection of histamine and metabolites in the fingernails of pregnant women’s fingernails is the first published.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. Koyama, A. Takeuchi, C. Tode, M. Shimizu, I. Morita, M. Nobukawa, M. Nobukawa, and N. Kobayashi, J. Chromatogr. B, 2009, 877, 207.

    Article  CAS  Google Scholar 

  2. J. Liu, L. Wang, W. Hu, X. Chen, and D. Zhong, J. Chromatogr. B, 2014, 971, 35.

    Article  CAS  Google Scholar 

  3. O. Comas-Basté, M. L. Latorre-Moratalla, R. Bernacchia, M. T. Veciana-Nogués, and M. C. Vidal-Carou, J. Pharm. Biomed. Anal., 2017, 145, 379.

    Article  PubMed  Google Scholar 

  4. H. G. Schwelberger, Inflamm. Res., 2009, 58, 51.

    Article  PubMed  Google Scholar 

  5. H. G. Schwelberger, Inflamm. Res., 2010, 59, 219.

    Article  Google Scholar 

  6. C. Poli, M. Laurichesse, O. Rostan, D. Rossille, P. Jeannin, M. Drouet, G. Renier, A. Chevailler, K. Tarte, C. Bendavid, C. Beauvillain, and P. Amé-Thomas, J. Pharm. Biomed. Anal., 2016, 118, 307.

    Article  CAS  PubMed  Google Scholar 

  7. Y. Itoh, R. Oishi, N. Adachi, and K. Saeki, J. Neurochem., 1992, 58, 884.

    Article  CAS  PubMed  Google Scholar 

  8. Y. Miyamoto, R. Yoshimoto, M. Yumoto, A. Ishihara, K. Takahashi, H. Kotani, A. Kanatani, and S. Tokita, Anal. Biochem., 2004, 334, 89.

    Article  CAS  PubMed  Google Scholar 

  9. K. Kuruma and T. Sakano, Anal. Sci., 1999, 15, 489.

    Article  CAS  Google Scholar 

  10. M. Previati, A. Raspadori, L. Bertolaso, A. Parmeggiani, D. Bindini, C. Vitali, I. Lanzoni, E. Corbacella, M. Saviano, F. Fagioli, G. Blo, and S. Capitani, J. Chromatogr. B, 2002, 780, 331.

    Article  CAS  Google Scholar 

  11. A. Yamatodani, H. Fukuda, H. Wada, T. Iwaeda, and T. Watanabe, J. Chromatogr., 1985, 344, 115.

    Article  CAS  PubMed  Google Scholar 

  12. Z. Wang, J. Wu, S. Wu, and A. Bao, Anal. Chim. Acta, 2013, 774, 1.

    Article  CAS  PubMed  Google Scholar 

  13. Y. Zhang, F. D. Tingley III, E. Tseng, M. Tella, X. Yang, E. Groeber, J. Liu, W. Li, C. J. Schmidt, and R. Steenwyk, J. Chromatogr. B, 2011, 879, 2023.

    Article  CAS  Google Scholar 

  14. J. Z. Min, H. Yano, A. Matsumoto, H. Yu, Q. Shi, T. Higashi, S. Inagaki, and T. Toyo'oka, Clin. Chim. Acta, 2011, 412, 98.

    Article  CAS  PubMed  Google Scholar 

  15. J. Z. Min, M. Yamamoto, H. Yu, T. Higashi, and T. Toyo'oka, Anal. Biochem., 2012, 424, 187.

    Article  CAS  PubMed  Google Scholar 

  16. J. Z. Min, A. Matsumoto, G. Li, Y.-Z. Jiang, H. Yu, K. Todoroki, K. Inoue, and T. Toyo'oka, Biomed. Chromatogr., 2014, 28, 492.

    Article  CAS  PubMed  Google Scholar 

  17. J. Z. Min, S. Hatanaka, H. Yu, T. Higashi, S. Inagaki, and T. Toyo'oka, Anal. Methods, 2010, 2, 1233.

    Article  CAS  Google Scholar 

  18. J. Z. Min, S. Hatanaka, H. Yu, T. Higashi, S. Inagaki, and T. Toyo'oka, J. Chromatogr. B, 2011, 879, 3220.

    Article  CAS  Google Scholar 

  19. J. Z. Min, Yakugaku Zasshi, 2014, 134, 1191.

    Article  CAS  Google Scholar 

  20. J. Z. Min, Y. Morota, Y.-Z. Jiang, G. Li, D. Jin, D. Kang, H-F. Yu, K. Inoue, K. Todoroki, and T. Toyo'oka, Eur J. Mass Spectrom., 2014, 20, 477.

    Article  CAS  Google Scholar 

  21. X. L. Li, G. Li, Y. Z. Jiang, D. Kang, C. H. Jin, Q. Shi, T. Jin, K. Inoue, K. Todoroki, T. Toyo'oka, and J. Z. Min, J. Chromatogr. B, 2015, 1002, 394.

    Article  CAS  Google Scholar 

  22. X. L. Li, Q. Shi, W. Jin, G. Li, K. Todoroki, H. Mizuno, T. Toyo’oka, and J. Z. Min, Biomed. Chromatogr., 2016, 30, 1338.

    Article  CAS  PubMed  Google Scholar 

  23. S. Oguri and Y. Yoneya, J. Chromatogr. B, 2002, 781, 165.

    Article  CAS  Google Scholar 

  24. M. Previati, A. Raspadori, L. Bertolaso, A. Parmeggiani, D. Bindini, C. Vitali, I. Lanzoni, E. Corbacella, M. Saviano, F. Fagioli, G. Blo, and S. Capitani, J. Chromatogr. B, 2002, 780, 331.

    Article  CAS  Google Scholar 

  25. S. Oguri and Y. Yoneya, J. Chromatogr. B, 2002, 781, 165.

    Article  CAS  Google Scholar 

  26. T. Toyo’oka, Biomed. Chromatogr., 2008, 22, 919.

    Article  PubMed  Google Scholar 

  27. T. Nakano, K. Todoroki, Y. Ishii, C. Miyauchi, A. Palee, J. Z. Min, K. Inoue, K. Suzuki, and T. Toyo’oka, Anal. Chim. Acta, 2015, 880, 145.

    Article  CAS  PubMed  Google Scholar 

  28. K. C. Chimalakonda, E. Pang, J. L. Weaver, K. E. Howard, V. Patel, and M. T. Boyne II, J. Pharm. Biomed. Anal., 2015, 102, 494.

    Article  CAS  PubMed  Google Scholar 

  29. J. Liu, L. Wang, W. Hu, X. Chen, and D. Zhong, J. Chromatogr. B, 2014, 971, 35.

    Article  CAS  Google Scholar 

  30. T. Toyo’oka, A. Suzuki, T. Fukushima, and M. Kato, Anal. Biochem., 2004, 333, 236.

    Article  PubMed  Google Scholar 

  31. H. Kawanishi, T. Toyo’oka, K. Ito, M. Maeda, T. Hamada, T. Fukushima, M. Kato, and S. Inagaki, J. Chromatogr. A, 2006, 1132, 148.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The present research was supported by the Science and Technology Development Project of Jilin Province of China (20160101207JC), and the National Natural Science Foundation of China (81660594, 81360487).

Author information

Authors and Affiliations

  1. Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy Yanbian University and Department of Pharmacy, Yanbian University Hospital, Yanji, 133002, Jilin Province, China

    Qingkun Ma, Qing Shi, Chun-Yan Xu & Jun Zhe Min

  2. Laboratory of Analytical and Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga, Shizuoka, 422-8526, Japan

    Aoi Uchibe & Toshimasa Toyo’oka

Authors
  1. Qingkun Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Aoi Uchibe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Qing Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Toshimasa Toyo’oka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chun-Yan Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jun Zhe Min
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Chun-Yan Xu or Jun Zhe Min.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ma, Q., Uchibe, A., Shi, Q. et al. Development of Highly Sensitive Analysis Method for Histamine and Metabolites in Pregnant Women’s Fingernail by UPLC-ESI-MS. ANAL. SCI. 34, 1023–1029 (2018). https://doi.org/10.2116/analsci.18SCP09

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2116/analsci.18SCP09

Keywords

Search

Navigation