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Chiral Separation of Sertraline with Microemulsion Electrokinetic Chromatography on a Polymer/β-cyclodextrin Assembling Molecular Film Modified Capillary

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Abstract

A capillary modified by assembling a molecular film was presented for the chiral separation of sertraline by microemulsion electrokinetic chromatography. The assembling molecular film was constructed with poly(diallyldimethylammonium-chloride) and β-cyclodextrin via inclusion complexation. The separation efficiency of cis-trans isomers and enantiomers of sertraline was improved with a running microemulsion that contained the acetonitrile, sodium dodecyl sulfate, n-butanol and n-hexane buffered with sodium tetraborate. The baseline separation of four sertraline cis-trans isomers and enantiomers was achieved under the optimum conditions. The detection limit for isomers and enantiomers of sertraline (1S,4S, 1R,4R, 1S,4R, 1R,4S) was 0.15, 0.15, 0.30, 0.30 mg/L, respectively. The mechanism of chiral separation was studied and it could be applied for the determination of commercial Zoloft tablet samples satisfactorily.

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References

  1. C. Tannergre, H. Engman, L. Knutson, M. Hedeland, U. Bondesson, and H. Lennernals, Clin. Pharmacol. Ther., 2004, 75, 298.

    Article  Google Scholar 

  2. T. Wozniak, R. Bopp, and E. Jensen, J. Pharm. Biomed. Anal., 1991, 9, 363.

    Article  CAS  PubMed  Google Scholar 

  3. K. Altria, J. Chromatogr., A, 1999, 856, 443.

    Article  CAS  PubMed  Google Scholar 

  4. S. Terabe, K. Otsuka, K. Ichikawa, A. Tsuchiya, and T. Ando, Anal. Chem., 1984, 56, 111.

    Article  CAS  Google Scholar 

  5. J. Vindevogel and P. Sandra, “Introduction to Micellar Electrokinetic Chromatography”, 1992, Hüthig, Heidelberg.

    Google Scholar 

  6. L. Yang, D. Zhang, and Z. Yuan, Anal. Chim. Acta, 2001, 433, 23.

    Article  CAS  Google Scholar 

  7. J. Zukowski, V. Biasi, and A. Berthod, J. Chromatogr, A, 2002, 948, 331.

    Article  CAS  PubMed  Google Scholar 

  8. B. Chu, B. Guo, Z. Wang, and J. Lin, J. Sep. Sci., 2008, 31, 3911.

    Article  CAS  PubMed  Google Scholar 

  9. D. Chen, Y Chen, and Y Hu, Chromatographia, 2004, 60, 469.

    Article  CAS  Google Scholar 

  10. Z. Zhang, B. Yan, K. Liu, Y Liao, and H. Liu, Electrophoresis, 2009, 30, 379.

    Article  CAS  PubMed  Google Scholar 

  11. Z. Tang, T. Wang, and J. Kang, Electrophoresis, 2007, 28, 2981.

    Article  CAS  PubMed  Google Scholar 

  12. S. Hooper and M. Anderson, Electroanalysis, 2007, 19, 652.

    Article  CAS  Google Scholar 

  13. A. Wang, J. Xu, and H. Chen, Electroanalysis, 2007, 19, 674.

    Article  CAS  Google Scholar 

  14. Q. Zhang, J. Xu, H. Lian, X. Li, and H. Chen, Anal. Bioanal. Chem., 2007, 387, 2699.

    Article  CAS  PubMed  Google Scholar 

  15. D. Chen, S. Jiang, Y. Chen, and Y. Hu, J. Pharm. Biomed. Anal., 2004, 34, 239.

    Article  CAS  PubMed  Google Scholar 

  16. K. Kudo, K. Iwaya, C. Yomota, S. Morris, and M. Saito, Enantiomer, 2000, 5, 369.

    CAS  PubMed  Google Scholar 

  17. C. Eap, G. Bouchoux, M. Amey, N. Cochard, L. Savary, and P. Baumann, J. Chromatogr. Sci., 1998, 36, 365.

    Article  CAS  PubMed  Google Scholar 

  18. E. Lacassie, J. Gaulier, P. Marquet, J. Fabatel, and G. Lachâtre, J. Chromatogr, B, 2000, 742, 229.

    Article  CAS  Google Scholar 

  19. I. Mcintyre, C. King, V. Staikos, J. Gall, and O. Drummer, J. Forensic Sci., 1997, 42, 951.

    Article  CAS  PubMed  Google Scholar 

  20. A. Önal, E. Kepekçi, S. Çetin, and S. Ertürk, J. AOAC Int., 2006, 89, 966.

    Article  PubMed  Google Scholar 

  21. T. Buzinkaiová and J. Polonský, Electrophoresis, 2000, 21, 2839.

    Article  PubMed  Google Scholar 

  22. M. Schultz and E. Furlong, Anal. Chem., 2008, 80, 1756.

    Article  CAS  PubMed  Google Scholar 

  23. A. Batt, M. Kostich, and J. Lazorchak, Anal. Chem., 2008, 80, 5021.

    Article  CAS  PubMed  Google Scholar 

  24. A. Lajeunesse, C. Gagnon, and S. Sauvé, Anal. Chem., 2008, 80, 5325.

    Article  CAS  PubMed  Google Scholar 

  25. H. Hattori, K. Ito, M. Iwai, T. Arinobu, Y. Mizutani, T. Kumazawa, A. Ishii, O. Suzuki, and H. Seno, Forensic Toxicol., 2007, 25, 100.

    Article  CAS  Google Scholar 

  26. A. Ramirez, M. Mottaleb, B. Brooks, and C. Chambliss, Anal. Chem., 2007, 79, 3155.

    Article  CAS  PubMed  Google Scholar 

  27. S. Lucangioli, L. Hermida, V. Tripodi, V. Rodríguez, E. López, P. Rouge, and C. Carducci, J. Chromatogr, A, 2000, 871, 207.

    Article  CAS  PubMed  Google Scholar 

  28. X. Xu, X. Wang, Y Liu, B. Liu, H. Wu, and P. Yang, Rapid Commun. Mass Spectrom., 2008, 22, 1257.

    Article  CAS  PubMed  Google Scholar 

  29. Y. Cao, W. Gong, N. Li, C. Yin, and Y Wang, Anal. Bioanal. Chem., 2008, 392, 1003.

    Article  CAS  PubMed  Google Scholar 

  30. L. Giannini, S. Orlandini, R. Gotti, S. Pinzauti, and S. Furlanetto, Talanta, 2009, 80, 781.

    Article  CAS  PubMed  Google Scholar 

  31. C. Yin, S. Ding, W. Gong, and Y. Cao, Chin. J. Anal. Chem., 2008, 9, 1177.

    Google Scholar 

  32. K. Altria, B. Clark, and P. Mahuzier, Chromatographia, 2000, 52, 758.

    Article  CAS  Google Scholar 

  33. F. Erim, A. Cifuentes, H. Poppe, and J. Kraak, J. Chromatogr, A, 1995, 708, 356.

    Article  Google Scholar 

  34. B. Chu, B. Guo, Z. Wang, and J. Lin, J. Sep. Sci., 2008, 31, 3911.

    Article  CAS  PubMed  Google Scholar 

  35. M. Fang, Y Cheng, J. Zhang, Q. Wu, J. Hu, L. Zhao, and T. Xu, J. Phys. Chem. B, 2010, 114, 6048.

    Article  CAS  PubMed  Google Scholar 

  36. M. Fechner, S. Kosmella, and J. Koetz, J. Colloid Interface Sci., 2010, 345, 384.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Qianli Zhang or Yifeng Tu.

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Cheng, H., He, B., Zhang, Q. et al. Chiral Separation of Sertraline with Microemulsion Electrokinetic Chromatography on a Polymer/β-cyclodextrin Assembling Molecular Film Modified Capillary. ANAL. SCI. 26, 1087–1092 (2010). https://doi.org/10.2116/analsci.26.1087

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  • DOI: https://doi.org/10.2116/analsci.26.1087

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