Cent Eur J Public Health 2014, 22(3):159-163 | DOI: 10.21101/cejph.a3894

Combined Effect of Selected Mineral Fibres and Tobacco Smoke on Respiratory Tract in Rats

Marta Hurbánková, Dominika Hrašková, Milan Beňo, Silvia Černá, Soňa Wimmerová, Štefánia Moricová
Laboratory of Respiratory Toxicology, Faculty of Public Health, Slovak Medical University in Bratislava, Bratislava, Slovak Republic

The rats were inhaling amosite and wollastonite fibres at two concentrations (30 and 60 mg/m3) one hour every second day and cigarette smoke of 3 cigarettes per day (with the exception of Saturdays and Sundays). They were sacrificed after 6 month of exposure. Bronchoalveolar lavage (BAL) was performed and selected inflammatory and cytotoxic parameters were examined. Amosite: inflammatory parameters were the most changed after 60 mg/m3 in both groups with or without smoking; the cytotoxic parameters were strongly influenced by smoking. Wollastonite (asbestos substitute) inhalation confirmed lower inflammatory and cytotoxic effects on all examined animal groups in comparison with amosite.

Keywords: fibrous dusts, cigarette smoke, combined effect, bronchoalveolar lavage, inflammatory and cytotoxic parameters, inhalation exposure

Received: March 23, 2013; Revised: June 27, 2014; Accepted: June 27, 2014; Published: September 1, 2014  Show citation

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Hurbánková M, Hrašková D, Beňo M, Černá S, Wimmerová S, Moricová Š. Combined Effect of Selected Mineral Fibres and Tobacco Smoke on Respiratory Tract in Rats. Cent Eur J Public Health. 2014;22(3):159-163. doi: 10.21101/cejph.a3894. PubMed PMID: 25438392.
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