Mental health and weight regain after bariatric surgery: associations between weight regain and psychiatric and eating-related comorbidities

ABSTRACT Objective Weight regain is a common outcome of weight loss interventions. Mental health-related comorbidities, among other factors, can mediate weight regain regardless of the implemented treatment modality. This study explores whether postoperative psychopathological comorbidities are associated with weight regain after bariatric surgery. Subjects and methods This cross-sectional study recruited 90 outpatients who underwent Roux-en-Y gastric bypass surgery. Anthropometric measurements were collected retrospectively from medical charts. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorder-IV (DSM-IV) Axis I Disorders (SCID-I) was applied to evaluate psychiatry diagnoses. Validated self-report instruments were used to assess depression, anxiety, alcohol use, impulsivity, binge eating, and body image dissatisfaction. Weight regain was defined as a ≥20% increase from the maximum weight lost. Level of evidence: Level III, cross-sectional study based on a well-designed study. Results Overall, 55.6% of participants experienced weight regain. Notably, mental disorders such as current binge-eating disorder and lifetime diagnoses including bulimia nervosa, alcohol abuse/dependence, and obsessive-compulsive disorder were significantly associated with weight regain. However, controlled analysis found that, for mental disorders, only current binge-eating disorder (odds ratio [OR] 6.3, 95% confidence interval [CI] 1.26-31.06, p = 0.024) remained associated with weight regain. Eating-related psychopathologies also associated with weight regain included binge eating (d = 0.55; p = 0.013), eating disinhibition (d = 0.76; p = 0.001), higher hunger levels (d = 0.39; p = 0.004), and non-planning trait impulsivity (d = 0.69; p = 0.0001). Conclusion Postoperative presence of psychopathological comorbidities, such as eating psychopathology and trait impulsivity, were associated with weight regain after bariatric surgery. These findings highlight the importance of addressing mental health in individuals experiencing postsurgical weight regain.


INTRODUCTION
B ariatric surgery is widely recognized as the standard treatment for severe obesity (1).Numerous studies have consistently demonstrated the benefits of bariatric surgery, including significant weight loss, improved control or resolution of clinical comorbidities, and enhanced quality of life (2).However, it is important to acknowledge that weight regain can occur after this type of surgery, with reported incidences ranging from 9% to 91% (3).The variability in reported rates is influenced by the differing definitions of weight regain across various studies and the absence of a standardized definition, making it challenging to address this outcome consistently (2,3).Some evidence suggests the use of the percentage of the maximum amount of weight lost from the lowest postoperative weight after surgery as a standardized measure to assess weight regain (2)(3)(4)(5).A reduction exceeding 20% from this parameter is considered a possible marker of significant weight recidivism (2).Addressing this evidence-based categorization in clinical investigations could contribute to improving our understanding of this outcome following bariatric surgery.
Several risk factors have been identified as potentially contributing to weight regain after bariatric surgery, including the natural course of obesity, surgicalrelated factors, behavioral aspects, and clinical variables (1).Significant weight regain following bariatric surgery may lead to the deterioration of metabolic improvements achieved through the procedure, including increased insulin resistance, reemergence of diabetes, worsening nonalcoholic fatty liver disease, and recurrence of obesity-related comorbidities (2,6,7).Moreover, a growing body of evidence suggests that psychopathological comorbidities may contribute to poor bariatric surgery outcomes (4).
There is robust evidence showing an increase in poor mental health in individuals with obesity compared with those with a normal body mass index (BMI) (8), indicating a greater association between clustering of physical multimorbidity and mental health in individuals with obesity (8,9).Studies reporting such evidence indicate common pathways linking obesity to mental disorders, including genetic influence, obesity biomarkers (insulin resistance, inflammatory processes, oxidative damage), environmental factors (alcohol use, physical inactivity, socioeconomic status), and distress (8)(9)(10)(11).
The frequency of comorbid mental disorders in individuals with severe obesity seeking bariatric surgery is higher than that in the general population (12).Previous studies have focused on the relationship between psychopathological comorbidities prior to bariatric surgery and weight regain (5,(13)(14)(15)(16)(17).Most of these studies have shown that preoperative psychopathology did not result in a greater degree of weight regain (18).However, the course of psychiatric comorbidities after bariatric surgery remains unclear.Some prospective studies have reported a decline (14,15,19) in comorbid mental disorders after bariatric surgery compared with the preoperative period, while others have reported that the incidence remained stable or increased in the long term after surgery (14,16).When considering eating psychopathology specifically, a subgroup of individuals may experience a reduction in their eating psychopathological symptoms after bariatric surgery (5).
Some studies have shown that postoperative psychopathology, such as depressive symptoms (20) and attentional impulsivity (21), are positively associated with weight regain (13) and deterioration in health-related quality of life (22,23).A metaanalysis published in 2019 found that postoperative eating psychopathologies, such as binge eating, loss of control while eating, and grazing, are associated with a greater risk (odds ratio [OR] 2.2) of weight regain (13).To summarize, the available evidence suggests that individuals undergoing bariatric surgery are more susceptible to mental disorders both before and after surgery (12,24).
Mental impairment has a complex nature and can be conceptualized as diagnostic categories or clusters of psychopathological symptoms (16).While the categorical perspective determines the presence or absence of a specific mental disorder, the dimensional perspective considers the existence of psychopathology along a continuum of normal to severe (25).This difference in assessment could contribute to the superior ability of the dimensional approach in detecting subtle mental impairment phenomena (16).Therefore, an analysis that considers both parameters could be more sensitive and accurate for evaluating psychopathological manifestations, especially among individuals undergoing bariatric surgery, due to the anatomic and metabolic changes induced by the procedure (26).
Given these observations, the present study used a structured assessment methodology to investigate the interplay between postoperative psychopathology (categorical and dimensional) and weight regain after bariatric surgery.The aim of the study was to investigate the relationship between weight regain and psychopathology among patients who had undergone Roux-en-Y gastric bypass (RYGB) and had a minimum postoperative period of 18 months.This time frame was chosen based on the weight trajectory following RYGB and the occurrence of weight regain.

Participants
The present study used a convenience sample and was conducted at the Bariatric Surgery Program of the Clementino Fraga Filho University Hospital at the Federal University of Rio de Janeiro (UFRJ).The inclusion criteria were participants who (A) had undergone RYGB, (B) were 18 years or older, (C) were of any sex, and (D) had a minimum postoperative period of 18 months.The exclusion criteria were (A) untreated endocrine disease, (B) pregnancy, or (C) corticosteroid use.
The institutional review board approved the study protocol (CAAE number: 53712516.6.0000.5257).All participants provided written informed consent before undergoing any study procedure.

Procedures and assessments
A total of 125 individuals who had undergone RYGB surgery were sequentially contacted and invited to participate during their appointments at the hospital or via telephone between September 2016 and October 2018.Of all individuals contacted, 90 (72%) completed the full research protocol (Figure 1).
The participants were evaluated by psychiatrists (MFFPM and JCH) experienced and trained in the use of psychiatric assessment instruments.During the faceto-face interview, the following variables were collected: • Demographics.
• Clinical variables.We collected data on psychiatric medication use, including the names of the medications and their frequency of utilization.Subsequently, we classified these medications into categories, which included antidepressants, antianxiety drugs, anticonvulsants, antipsychotics, medications for mania/mood stabilizers, and central nervous system stimulants (14).• Occurrence of mental disorders (current and lifetime) and psychopathological symptoms (self-report scales), assessed using a structured interview.• Weight, collected retrospectively from the participants' medical charts and measured at admission in the surgical unit.We collected the following parameters: preoperative weight, measured on surgery day, and lowest postoperative weight.The current weight was measured during the face-to-face interview using a balance beam scale and with the participants without shoes and wearing light clothes.In the cases we did not find reliable information regarding the lowest postoperative weight in the medical charts, we considered the postoperative lowest weight reported by the participant.• Height, collected from the participants' medical charts and measured at admission in the surgical unit.To assess the impact of time in our analysis, we created groups based on the postoperative time in months (short/medium follow-up group: 18-59 months; longer follow-up group: ≥60 months) (27).The time required to achieve maximum weight loss was calculated as the difference between the date of the surgery (month/year) and the date of the minimum postoperative weight (month/year).Subsequently, groups for the time to achieve maximum weight loss were defined as 0-24 months and >24 months (2).

Mental health assessment Mental disorders (categorical)
Mental disorders were assessed using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) Axis I Disorders (SCID-I), a semi-structured interview tool used to classify mental disorders.The SCID-I Patient Edition is a well-validated instrument for the assessment of current and lifetime diagnoses of mental disorders.The SCID-I version used had been translated into Portuguese and adapted to the Brazilian population (28).The eating disorders section was based on the classification criteria established by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) (29).
Specific psychopathologies were evaluated using validated self-report questionnaires during in-person assessment to determine current psychopathology.

General psychopathology (dimensional)
For general psychopathology, participants completed the Beck Depression Inventory (BDI), which contains 21 self-rated items measuring the intensity of depressive symptoms in the past 2 weeks (30).Trait impulsivity was assessed using the Barratt Impulsiveness Scale (BIS-11), a self-reported 30-item Likert scale that measures impulsiveness in different domains, namely, motor impulsiveness (incoherent action in a given context), attentional impulsiveness (inability to focus attention or concentrate), and non-planning impulsiveness (decrease in orientation toward the future); higher scores indicate greater severity of impulsiveness (31).

Eating psychopathology (dimensional)
Eating psychopathology was assessed using the Binge Eating Scale (BES), a 16-item Likert scale measuring the severity of binge eating (≥27 = severe; 18-26 = moderate; ≤17 = no binge eating) (32).Additionally, the Three-Factor Eating Questionnaire (TFEQ) (33), a 51-item scale, was applied to measure eating behavior in three domains: restriction (restricting food intake to control body weight), disinhibition (tendency toward overeating and eating in response to external food stimuli), and hunger (eating episodes elicited by hunger signals) (34).Finally, body shape concerns were evaluated using the Body Shape Questionnaire (BSQ), a 34-item Likert scale that quantifies concerns about body image in the past 4 weeks (35).The self-report instruments used in this study had been validated in the context of the Brazilian population (30)(31)(32)34,35).

Weight regain
Weight regain was calculated as the percentage of weight regained after surgery, considering the difference between the current weight and the lowest weight after surgery, relative to the difference between the weight measured before and after surgery: [100*(current weight -lowest postoperative weight)] / (preoperative weight -lowest postoperative weight)], in which the lowest postoperative weight was the minimum postoperative weight achieved after the RYGB (2).Participants were stratified into groups based on a weight regain cutoff value of ≥20%, per this calculation.Thus, patients with weight regain ˂20% were classified into the non-weight regain group ("NWR group"), while those with weight regain ≥20% were included in the weight regain group ("WR group") (1).

Weight loss
Weight loss after surgery was calculated as a percentage of preoperative weight and BMI variation.We applied the calculation of the total weight loss using the formula: [100*(preoperative weight -current weight) / preoperative weight] (27).Subsequently, we defined groups based on total weight loss <20% and ≥20% to examine insufficient weight loss (3).The weight loss measure of percent excess weight loss was also calculated.The calculation was based on the formula: [(preoperative weight -current weight) / (preoperative weight -ideal weight)].We then defined groups based on percent excess weight loss <50% and ≥50% to investigate a surgical nonresponse (3).A BMI change was calculated as follows: [preoperative BMI -current postoperative BMI] (3,27).

Statistical analysis
Descriptive analyses were performed to summarize the demographic data, anthropometric measurements, and clinical variables (frequencies and percentages for categorical variables and medians with minimum-maximum values for continuous variables).Our dependent variable was weight regain at the established cutoff (≥20% from the maximum weight loss).Independent variables included clinical variables (psychiatric medication use, postoperative time as a continuous variable in months, postoperative time groups based on short/medium follow-up Bariatric surgery and mental health Arch Endocrinol Metab, 2024, v.68, 1-13, e230208. [18-59 months], and longer follow-up [participants included if they had ≥60 months of postoperative time]), mental disorders (lifetime and current), and psychopathological symptoms (binge eating measured by the BES, eating behavior assessed by TFEQ, shape concerns evaluated by BSQ, depressive symptoms assessed by BDI, and trait impulsivity measured by BIS-11).
The Mann-Whitney U test for nonparametric data was performed to compare continuous clinical variables, psychopathological symptoms measured by the self-report questionnaires, and the defined weight regain cutoff.The effect size was calculated based on the median differences between the groups, with the standard deviation in the variance of this calculation.Subsequently, the statistical significance of the effect size was calculated using Cohen's d statistic.We adopted Cohen's suggestion that d values of 0.2, 0.5, and 0.8 could be considered to represent a small, medium, and large effect size, respectively (36).The frequencies of mental disorders in the weight regain categories were compared using the chi-squared test.
We conducted a stepwise automatic logistic regression analysis controlling for confounding variables in the association between mental disorders and weight regain.First, covariates (sex, postoperative time groups, postoperative time to the maximum weight loss groups, lifetime obsessive-compulsive disorder, lifetime alcohol abuse/dependence, lifetime bulimia nervosa, and current binge-eating disorder) were introduced into the model.Second, only covariates that remained statistically significant in the equation were described, and their ORs were calculated along with 95% confidence intervals (CIs).
The data were analyzed using the Statistical Package for Social Sciences (SPSS), Version 21 (IBM Corp., NY, USA).Statistical significance was set at p < 0.05.
In the sample (n = 90), 57.7% (n = 52) and 76.6% (n = 69) participants had a current and lifetime mental disorder, respectively.Mood disorders were the most frequent diagnostic category in the entire sample, with 41.1% (n = 37) of participants presenting a lifetime and 30% (n = 27) a current mood disorder.Lifetime major depressive disorder was the most prevalent diagnosis, observed in 41.1% (n = 37) participants, followed by current depressive episode, observed in 28.8% (n = 26) of them.Of note, 60% (n = 54) of participants displayed some type of anxiety disorder.Specifically, 53.3% (n = 48) of participants met diagnostic criteria for a lifetime anxiety disorder, while 38.9% (n = 35) had a current anxiety disorder.Lifetime specific phobia had the highest prevalence in the overall sample (23.3%; n = 21), followed by lifetime social phobia (16.6%; n = 15), current generalized anxiety disorder (13.3%; n = 13), and lifetime generalized anxiety disorder (4.4%; n = 4).Additionally, 27.7% (n = 25) of participants met diagnostic criteria for lifetime post-traumatic stress disorder and 14.1% (n = 13) for current post-traumatic stress disorder.Lifetime alcohol abuse was present in 13.3% (n =12) of the sample, while a diagnosis of current alcohol abuse was present in 11.1% (n = 10).Lifetime binge-eating disorder was the second most prevalent mental disorder, occurring in 36.6% (n = 33) of participants.

Association between mental disorders and weight regain
Comparing the groups, when the mental disorders were pooled in a class analysis for the presence of any lifetime or current mental disorder, the WR group (n = 50) exhibited a prevalence of 86% (n = 43) compared with 72.5% (n = 29) in the NWR group (n = 40).However, these differences between the NWR and WR groups were only significant for specific mental disorders, namely, alcohol abuse/dependence (5% versus 20%, respectively, p = 0.03), obsessive-compulsive disorder (2.5% versus 14%, respectively, p = 0.05), current bingeeating disorder (7.5% versus 24%, respectively, p = 0.03), and lifetime bulimia nervosa (0 versus 12%, respectively, p = 0.02).Differences in prevalence of mental disorders between the groups are shown in Table 2.
The controlled analysis examining the association between the WR cutoff and mental disorders revealed that only current binge-eating disorder remained significantly associated with the dependent variable (OR 6.3, 95% CI 1.26-31.06;p = 0.024), as shown in Table 3.

Association between psychopathology and weight regain
We found significant differences in psychopathology intensity between groups in terms of binge eating (BES), eating behaviors dimensions of disinhibition, restriction, and hunger (TEFQ), and non-planning impulsivity (BIS-11).The results for the comparison between the level of psychopathology and the weight regain groups are shown in Table 4.The effect size for the psychopathology degree and TFEQ restriction (d = -0.60)and hunger (d = 0.39) was small.We found a medium effect size of the BES score (d = 0.55), TFEQ disinhibition (d = 0.76), and BIS-11 domain of non-planning impulsivity (d = 0.69) for weight regain.

DISCUSSION
The present study confirmed the association between multiple mental health domains and weight regain in patients undergoing bariatric surgery.Notably, the frequency of psychiatric comorbidities (categorical), such as current binge-eating disorder, lifetime bulimia nervosa, lifetime obsessive-compulsive disorder, and alcohol abuse/dependence, was significantly higher in participants with weight regain.Furthermore, in terms of psychopathology assessed dimensionally, disordered eating behavior and impulsivity were significantly higher in participants with postoperative weight regain.However, after a controlled analysis, only binge-eating disorder remained significantly associated with weight regain.
We found an increased prevalence of mental disorders and higher levels of psychopathology, which is consistent with other studies (8,12,14,37) demonstrating that the bariatric surgery population and individuals with severe obesity often have psychiatric comorbidity.In our sample, 40% of participants were using psychiatric medications.However, as we reported, there was no significant difference in weight regain comparing the groups with and without the use of psychopharmacotherapy.This is comparable to the results of a 7-year prospective study by Kalarchian and cols., which reported that 37.7% of the participants were on some form of psychiatric medication (14).Furthermore, Kalarchian and cols.found no significant difference in weight regain associated with the use of psychiatric medication (14,38).This finding deserves attention because individuals with psychiatric disorders may need closer postoperative follow-up.
We found a significantly higher lifetime prevalence of obsessive-compulsive disorder and alcohol abuse/ dependence in participants with weight regain compared with those without weight regain.Considering the lack of information regarding the association between weight regain and general psychiatric comorbidity (13), this is a unique finding.Although a higher incidence of obsessive-compulsive disorder has been reported in bariatric surgery candidates (39,40) compared with individuals with severe obesity who are not candidates for bariatric surgery, our data suggests a relationship between this lifetime mental disorder and a poor surgical weight outcome.A potential explanation for this finding is that individuals with obsessive-compulsive disorder may have greater difficulty adhering to follow-up visits and recommendations because of their psychiatric impairment (40).In our study, weight regain was associated with higher rates of lifetime problematic alcohol use, with 10% showing current issues and 13.3% having a lifetime history, consistent with similar studies on patients at postoperative RYGB Bariatric surgery and mental health Arch Endocrinol Metab, 2024, v.68, 1-13, e230208.(41).However, the link between lifetime problematic alcohol use and weight regain remains unclear and requires further investigation.Some evidence suggests that metabolic changes following the RYGB procedure may reduce alcohol appeal for certain individuals (42).Additionally, those with a history of problematic alcohol use may draw upon coping skills from substance abuse treatment to adopt healthier habits after bariatric surgery (42), potentially explaining a proportional prevalence of current alcohol problems among our weight regain groups.
Our data indicate a significant association between lifetime diagnosis of bulimia nervosa and current binge-eating disorder with weight regain after RYGB surgery.However, the application of DSM-5 criteria to assess binge-eating spectrum disorders in this population may underestimate their prevalence due to anatomical restrictions imposed by the surgical procedure, potentially impacting the amount of food consumed during binge episodes (43).This could make the marker "loss of control while eating" more accurate for this group.In a prospective study of 748 individuals who had undergone bariatric surgery, Hilbert and cols.( 43) investigated the differences in prevalence of bingeeating spectrum disorders when assessing them based on DSM-5 criteria compared with diagnoses centered on the loss of control rather than the quantity of food consumed.In the fourth year of assessment, they found a prevalence of binge-eating disorder of 0.88% using the DSM-5 criteria, compared with 1.76% when focusing on the loss of control marker.Therefore, our findings related to binge-eating disorder and bulimia nervosa based on DSM-5 criteria could be underrated.Even though the presence of binge-eating symptoms has been related to less weight loss and/or more weight regain postoperatively (18,44), various authors (13,18,45) have identified methodological flaws in the existing evidence.These authors have pointed out the need for studies using validated interviews and not only self-reported questionnaires to assess eating disorder diagnoses.Thus, the results of the present study add relevant information regarding the relationship between eating disorders and the bariatric surgery outcome of weight regain.
Overall, our findings suggest that mental disorders such as obsessive-compulsive disorder, substance use disorders, binge-eating disorder, and bulimia nervosa, which share common features of the impulsivitycompulsivity spectrum, were associated with weight regain after RYGB surgery (46).These features include emotional dysregulation or disinhibition (loss of control over eating), impulsivity, and compulsive behaviors (47)(48)(49).The interplay of these behaviors may contribute to a suboptimal outcome after bariatric surgery, including weight regain and psychosocial distress.
In the present study, postoperative weight regain was positively associated with binge-eating symptoms, eating disinhibition, and non-planning impulsivity, and negatively associated with restrictive eating habits, with moderate effect sizes.Our findings are consistent with previous studies (13,50,51) and suggest that postoperative binge eating is associated with unfavorable weight outcomes in bariatric surgery.Likewise, Dos Rodrigues in 2021 (52) and Amundsen in 2017 (53) applied the TEFQ to individuals who had undergone bariatric surgery and found that those with weight regain had a significant increase in eating disinhibition and a decrease in restrictive eating.Thus, the results of the present study revealed that binge eating, eating disinhibition, and lower food restriction were associated with weight regain.These eating behaviors may be influenced by the long-term physiological changes induced by bariatric surgery, whereas decreased hunger satiation signals, hormonal changes, and biochemical modifications may be responsible for increased eating disorder scores (26).Finally, regarding impulsivity, Marchitelli and cols. in 2022 (54) followed longitudinally 47 patients after bariatric surgery and found that non-planning impulsivity was a reliable short-term predictor of weight loss after bariatric surgery.As non-planning impulsiveness interferes with the ability to predict the consequences of one's actions and to plan accordingly, this dimension of impulsivity (49) may have influenced adherence, leading to dysfunctional weight regain behaviors.
According to some evidence, alterations in the anatomical (gastric volume), metabolic (neurohormonal), and reward systems induced by bariatric surgery may impact the clinical presentation of psychopathology, especially disordered eating behaviors (55).First, the limitation in the gastric volume could limit the quantity of food that patients can eat postoperatively, while dysfunctional eating behaviors could change from overeating to eating smaller quantities.However, these alterations in eating habits could also induce emotional distress, owing to the loss of control over the amount of food compared with the preoperative quantity (18).

Bariatric surgery and mental health
Arch Endocrinol Metab, 2024, v.68, 1-13, e230208.Some gastrointestinal symptoms may develop de novo following bariatric surgery, including vomiting, dumping syndrome (resulting from rapid gastric emptying or reactive hypoglycemia), dysphagia, and chewing and spitting food (56,57).In the context of bariatric surgery procedures, it is important to consider that these gastrointestinal symptoms may be direct consequences of the surgical procedure rather than being strictly compensatory behaviors aimed at preventing weight gain (56,57).Second, after bariatric surgery, peripheral metabolic changes in gut hormones, peptides, microbiota, peripheral adiposity signals, and vagal tonus could affect general and eating psychopathology (26).These peripheral changes could influence eating psychopathology by modifying hunger homeostasis (satiety and hunger perception), which affects the amount of food consumed (26).Bariatric surgery can induce complex biological changes that interact with neurobehavioral features.However, this incipient research field requires more evidence to better elucidate these associations.

Strengths and limitations
Some limitations of the study must be considered, including its cross-sectional design, which renders inferences and determination of long-term consequences questionable.Moreover, conclusive associations cannot be determined without an epidemiological or prospective study design, owing to the sample size and low frequency of mental disorders, especially eating disorders (18).An additional limitation of our study is that it was based on a convenience sample, which could be a source of bias.We did not include the evaluation of problematic eating issues such as dumping syndrome, dysphagia, or the act of chewing followed by spitting out food.This omission limits the scope of discussions based on our findings regarding problematic eating following bariatric surgery.Additionally, we did not collect data on participants' maximum weight over the course of their lives, which could have potentially affected the interpretation of our weight-related outcomes.Also, some of the weight measurements applied in this study were self-reported, even though they can be adequately used in this postoperative population (58).The strengths of this study included the quality of outcome assessment with a standardized weight regain definition and validated instruments to assess mental health outcomes, including the DSM-5 criteria for eating disorder diagnoses.

Future direction
It is still unclear whether psychiatric comorbidity could trigger weight regain or vice versa (13).Future research with a large sample cohort, longitudinal design, and standardized weight regain definition (1) is needed.Moreover, the interplay between biological factors and mental health may explain how psychopathological comorbidities could impact weight regain (13,37).Future research should investigate this association with multiple mental health approaches, to better identify or predict impulsivity domains that can affect weight outcomes (59).Furthermore, timely targeted treatments based on specific psychiatric domains that are more prone to affect weight outcomes after bariatric surgery would be helpful (60).For instance, clinical settings should consider administering psychotropic drugs to treat psychiatric comorbidity, providing specific psychological interventions to support psychopathology impairment, or providing self-guided information to promote healthier habit modifications.Due to the association between binge-eating disorders/ behavior and weight regain, it is important to assess this behavior before and after bariatric surgery.A series of instruments, such as the Questionnaire on Eating and Weight Patterns-5 (QEWP-5) (61) and BES (62), may help clinicians and surgeons identify binge-eating behavior in this population.The adequate management of this condition may help overcome potential weight regain after bariatric surgery.
In conclusion, the findings of the present study indicate a high prevalence of poor mental health in patients experiencing weight regain after bariatric surgery.Thus, it is necessary to adequately assess and address mental health to improve the long-term outcomes of bariatric surgery.
Funding: this study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior -Brasil (Capes) -Finance Code 001.
Data availability: the study data are available from the corresponding author upon reasonable request.
Ethics approval and consent to publish: all participants provided written informed consent before undergoing any study procedure and agreed with the publication of their data in a scientific journal.and final approval of the manuscript version for publication.Marco Antônio Alves Brasil (HUCFF/UFRJ) -Contributed to the conception and design of the study protocol, critically reviewed the manuscript, and approved the final manuscript version for publication.João Regis Ivar Carneiro (HUCFF/ UFRJ) -Contributed to the conception and design of the study protocol, critically reviewed the manuscript, and approved the final manuscript version for publication.Ronir Raggio Luiz (Epidemiology/UFRJ) -Contributed to the conception and design of the protocol and to the data analysis and interpretation, critically reviewed the manuscript, and approved the final manuscript version for publication.João C. Hiluy (IPUB/ UFRJ) -Collaborated with the data collection and final review of the manuscript, and approved the final manuscript version for publication.José Carlos Appolinario (IPUB/UFRJ) -Study leader, mentor, and project supervisor.Contributed to the conception and design of the study protocol, data analysis and interpretation, and drafting of the manuscript, and approved the final manuscript version for publication.
Disclosure: Jose Carlos Appolinario receives/has received research grants, consultancy fees, and advisory board fees from Takeda and Janssen Pharmaceuticals.

Table 1 .
Demographic and clinical characteristics of individuals with and without weight regain after Roux-en-Y gastric bypass *The analysis was performed using the chi-square test for categorical variables and the Mann-Whitney U test for continuous variables.Significance was defined by a p value ≤ 0.05.Abbreviations: Δ, delta; %, percentage; BMI, body mass index, calculated as weight divided by the square of height; EWL; excess weight loss; NWR, no weight regain group; TWL, total weight loss; max, maximum; min, minimum; n, number; WR, weight regain group.

Table 2 .
Comparison of lifetime and current prevalence of mental disorders in individuals with and without weight regain after Roux-en-Y gastric bypass The analysis was performed using the chi-square test.Significance was defined by a p value ≤ 0.05.*The diagnosis of eating disorders was based on DSM-5 criteria.Abbreviations: N/A, not available; NWR, no weight regain; WR, weight regain.

Table 3 .
Multivariate logistic regression analysis* controlling for confounding variables (postoperative time, postoperative time to maximum weight loss, and psychiatric comorbidity) in the association between mental disorders and weight regain after bariatric surgery Dependent variable: weight regain ≥ 20% from the maximum weight lost.*Methodstepwise:In the first step, we introduced each covariate into the regression model, along with the dependent variable.The covariates were sex, postoperative time groups, postoperative time to maximum weight loss groups, lifetime obsessive-compulsive disorder, lifetime alcohol abuse/dependence, lifetime bulimia nervosa, and current binge-eating disorder.In the second step, we included only the covariates that remained statistically significant in the equation model after the first step.**Currentdiagnostic.Abbreviations: 95% CI, 95% confidence interval; OR, odds ratio.Bariatric surgery and mental healthArch Endocrinol Metab, 2024, v.68, 1-13, e230208.

Table 4 .
Comparison of general and eating psychopathologies in individuals with and without weight regain after Roux-en-Y gastric bypass (36)eral and eating psychopathology were evaluated during the in-person interview.**Analysisperformedusing the Mann-Whitney U test.Significance was defined by a p value ≤ 0.05.***Effectsize was calculated using Cohen's d statistic.According to Cohen, 0.2 could be considered a "small" effect size, 0.5 represents a "medium" effect size, and 0.8 a "large" effect size(36).Abbreviations: max, maximum; min, minimum; NWR, no weight regain; WR, weight regain.