Short-Term Evolution after Mitral Transcatheter Edge-to-Edge Repair: Clinical Value of Novel Echocardiographic Biomarkers

Javier Solsona-Caravaca; Rubén Fernández-Galera; Víctor González-Fernández; Lorenzo Airale; Johny Rivas; Luca Scudeler; Núria Vallejo; Gisela Teixidó-Turà; Guillem Casas; Filipa Valente; Ruper Oliveró; Yassin Belahnech; Gerard Martí; Bruno García; Ignacio Ferreira-González; José F. Rodríguez-Palomares; Laura Galian-Gay

doi:10.20944/preprints202405.0612.v1

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preprints.org > medicine and pharmacology > cardiac and cardiovascular systems > doi: 10.20944/preprints202405.0612.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Short-Term Evolution after Mitral Transcatheter Edge-to-Edge Repair: Clinical Value of Novel Echocardiographic Biomarkers

Javier Solsona-Caravaca

Rubén Fernández-Galera

Víctor González-Fernández

Ignacio Ferreira-González

^* ,

José F. Rodríguez-Palomares

^* ,

Laura Galian-Gay

Version 1 : Received: 8 May 2024 / Approved: 9 May 2024 / Online: 9 May 2024 (15:42:56 CEST)

How to cite: Solsona-Caravaca, J.; Fernández-Galera, R.; González-Fernández, V.; Airale, L.; Rivas, J.; Scudeler, L.; Vallejo, N.; Teixidó-Turà, G.; Casas, G.; Valente, F.; Oliveró, R.; Belahnech, Y.; Martí, G.; García, B.; Ferreira-González, I.; Rodríguez-Palomares, J. F.; Galian-Gay, L. Short-Term Evolution after Mitral Transcatheter Edge-to-Edge Repair: Clinical Value of Novel Echocardiographic Biomarkers. Preprints 2024, 2024050612. https://doi.org/10.20944/preprints202405.0612.v1 Solsona-Caravaca, J.; Fernández-Galera, R.; González-Fernández, V.; Airale, L.; Rivas, J.; Scudeler, L.; Vallejo, N.; Teixidó-Turà, G.; Casas, G.; Valente, F.; Oliveró, R.; Belahnech, Y.; Martí, G.; García, B.; Ferreira-González, I.; Rodríguez-Palomares, J. F.; Galian-Gay, L. Short-Term Evolution after Mitral Transcatheter Edge-to-Edge Repair: Clinical Value of Novel Echocardiographic Biomarkers. Preprints 2024, 2024050612. https://doi.org/10.20944/preprints202405.0612.v1

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MDPI and ACS Style

Solsona-Caravaca, J.; Fernández-Galera, R.; González-Fernández, V.; Airale, L.; Rivas, J.; Scudeler, L.; Vallejo, N.; Teixidó-Turà, G.; Casas, G.; Valente, F.; Oliveró, R.; Belahnech, Y.; Martí, G.; García, B.; Ferreira-González, I.; Rodríguez-Palomares, J. F.; Galian-Gay, L. Short-Term Evolution after Mitral Transcatheter Edge-to-Edge Repair: Clinical Value of Novel Echocardiographic Biomarkers. Preprints 2024, 2024050612. https://doi.org/10.20944/preprints202405.0612.v1

APA Style

Solsona-Caravaca, J., Fernández-Galera, R., González-Fernández, V., Airale, L., Rivas, J., Scudeler, L., Vallejo, N., Teixidó-Turà, G., Casas, G., Valente, F., Oliveró, R., Belahnech, Y., Martí, G., García, B., Ferreira-González, I., Rodríguez-Palomares, J. F., & Galian-Gay, L. (2024). Short-Term Evolution after Mitral Transcatheter Edge-to-Edge Repair: Clinical Value of Novel Echocardiographic Biomarkers. Preprints. https://doi.org/10.20944/preprints202405.0612.v1

Chicago/Turabian Style

Solsona-Caravaca, J., José F. Rodríguez-Palomares and Laura Galian-Gay. 2024 "Short-Term Evolution after Mitral Transcatheter Edge-to-Edge Repair: Clinical Value of Novel Echocardiographic Biomarkers" Preprints. https://doi.org/10.20944/preprints202405.0612.v1

Abstract

Background. Transcatheter edge-to-edge repair (TEER) is a safe and effective treatment in symptomatic patients with mitral regurgitation (MR). We aimed to investigate the short-term impact of mitral TEER on left ventricular (LV) performance and identify echocardiographic prognostic indicators. Methods. Seventy-eight patients with severe MR (organic and functional etiologies) were included retrospectively. All patients had a baseline and short-term echocardi-ography after TEER and were followed up for the primary composite endpoint (heart failure hos-pitalization and cardiovascular death) over a median period of 13 months. Results. A significant decrease in left ventricular ejection fraction (LVEF), all myocardial work indices (except global wasted work), and left atrial reservoir were observed after TEER. Additionally, there was an im-provement in the pulmonary artery systolic pressure and tricuspid annular plane systolic excur-sion/pulmonary artery systolic pressure (TAPSE/PASP) ratio. 34% of all patients presented the primary composite endpoint. A TAPSE/PASP ratio post-TEER < 0.47 (HR: 4.76, p-value = 0.039), and left atrial reservoir post-TEER < 9.0% (HR: 2.77, p-value = 0.047) were independently associ-ated with the primary endpoint. Conclusions. Echocardiography post-TEER reflects impairment in ventricular performance due to preload reduction and right ventricular to pulmonary artery coupling improvement. Short-term echocardiography after TEER identifies high-risk patients who could benefit from a close clinical follow-up.

Keywords

mitral regurgitation; transcatheter edge-to-edge repair; heart failure hospitalization; cardiovas-cular death; myocardial work; ventricle-pulmonary artery coupling; left atrial strain.

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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