Cimmino, A.; Fasciglione, G.F.; Gioia, M.; Marini, S.; Ciaccio, C. Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma. Int. J. Mol. Sci.2023, 24, 13344.
Cimmino, A.; Fasciglione, G.F.; Gioia, M.; Marini, S.; Ciaccio, C. Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma. Int. J. Mol. Sci. 2023, 24, 13344.
Cimmino, A.; Fasciglione, G.F.; Gioia, M.; Marini, S.; Ciaccio, C. Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma. Int. J. Mol. Sci.2023, 24, 13344.
Cimmino, A.; Fasciglione, G.F.; Gioia, M.; Marini, S.; Ciaccio, C. Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma. Int. J. Mol. Sci. 2023, 24, 13344.
Abstract
Phytoestrogens are plant-derived bioactive compounds with estrogen-like properties. Their potential health benefits, especially in cancer prevention and treatment, have been a subject of considerable research in the past decade. Phytoestrogens exert their effects, at least in part, through interactions with estrogen receptors (ERs), mimicking or inhibiting the actions of natural estrogens. Recently, there has been growing interest in exploring the impact of phytoestrogens on osteosarcoma (OS), a type of bone malignancy that primarily affects children and young adults, and currently presenting limited treatment options. Considering the critical role of estrogen/ERs axis in bone development and growth, the modulation of ERs has emerged as a highly promising approach in the treatment of OS. This review provides an extensive overview of current literature on the effects of phytoestrogens on human OS models. It delves into the multiple mechanisms through which these molecules regulate the cell cycle, apoptosis and key pathways implicated in the growth and progression of OS, including ERs signaling. Moreover, potential interactions between phytoestrogens and conventional chemotherapy agents commonly used in OS treatment will be examined. Understanding the impact of these compounds in OS holds great promise for developing novel therapeutic approaches that can augment current OS treatment modalities.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
