Evaluation of antidiabetic and antihyperlipidemic effects of Ougeinia oojeinensis in diabetic rats

Abstract

Ougeinia oojeinensis is a medicinal plant, used by herbalists for treating various diseases, one of which is diabetes mellitus. The aim of this study was to investigate the antidiabetic activity of Ougeinia oojeinensis bark and root extracts. The different doses of ethanol extracts of bark and root were administered orally in Streptozotocin (STZ)-induced diabetic rats. After the administration of extracts, blood glucose levels were monitored at specific intervals and it was found that they were significant lowered. The effect of extracts on induced hyperlipidemia was analyzed where the extracts significantly lowered the elevated total cholesterol, triglycerides (TGL) and low density lipoprotein (LDL) level while increased the High density lipoprotein (HDL). Glibenclamide was used as a standard drug at a dose of 0.50 mg/kg body weight. The experimental data revealed that extract has significant antidiabetic activity in streptozotocin-induced rats compared to standard drug.