Keywords
Cleft lip
Cleft palate
Dentition, mixed
Dentition, permanent
Tooth abnormalities
How to Cite
Abstract
Aim: To characterize the patterns of dental anomalies (DA) in the mixed and permanent dentitions of patients with nonsyndromic oral cleft (NSOC). Methods: This cross-sectional, observational, case-control study included 173 patients, 61 with mixed dentition (NSOC=29 and control=32) and 112 with permanent dentition (NSOC=57 and control=55). All subjected were submitted to clinical and radiographic examination. Dental anomalies of eruption, number, size and shape outside the cleft area were considered. Results: Although there was no statistical significance among patients with mixed dentition, dental agenesis was the anomaly more common in this group. In patients with permanent dentition, a higher prevalence of DA in NSOC group compared to control group was observed (p=0.02). Gyroversion and dental agenesis were the DA more frequently observed in the permanent dentition and the second premolar was the tooth more affected (p=0.003). Mandible and the left side were more involved, and dental agenesis was more frequently found in patients with unilateral cleft lip with or without cleft palate (NSCL±P). Conclusion: Our findings show a higher frequency of DA in NSOCs than in the control group in patients with permanent dentition, mainly due to a higher occurrence of agenesis of second premolars in patients with unilateral NSCL±P.
References
Konstantonis D, Alexandropoulos A, Konstantoni N, Nassika M. A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients. Prog Orthod. 2017;18(1):20. doi: 10.1186/s40510-017-0169-x.
Dixon MJ, Marazita ML, Beaty TH, Murray JC. Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet. 2011;12(3),167-78. doi: 10.1038/nrg2933.
Laganà G, Venza N, Borzabadi-Farahani A, Fabi F, Danesi C, Cozza P. Dental anomalies: prevalence and associations between them in a large sample of non-orthodontic subjects, a cross-sectional study. BMC Oral Health. 2017;17(1):62. doi: 10.1186/s12903-017-0352-y.
Boeira BR Jr, Echeverrigaray S. Dentistry and molecular biology: A promising field for tooth agenesis management. Tohoku J Exp Med. 2012 Apr;226(4):243-9. doi: 10.1620/tjem.226.243.
Fan L, Kan S, Yang F, Xu H, Li H, Zhu G, et al. Non-syndromic cleft lip with or without palate susceptible loci is associated with tooth agenesis. Oral Dis. 2019;25(3):803-11. doi: 10.1111/odi.13024.
Lancia M, Machado RA, Dionísio TJ, Garib DG, Santos CFD, Coletta RD, et al. Association between MSX1 rs12532 polymorphism with nonsyndromic unilateral complete cleft lip and palate and tooth agenesis. Arch Oral Biol. 2020;109:104556. doi: 10.1016/j.archoralbio.2019.104556.
Stahl F, Grabowski R, Wigger K. Epidemiology of Hoffmeister's "genetically determined predisposition to disturbed development of the dentition" in patients with cleft lip and palate. Cleft Palate Craniofac J. 2006;43(4):457-65. doi: 10.1597/04-156.1.
Tannure PN, Oliveira CA, Maia LC, Vieira AR, Granjeiro JM, Costa MC. Prevalence of dental anomalies in nonsyndromic individuals with cleft lip and palate: a systematic review and meta-analysis. Cleft Palate Craniofac J. 2012;49(2):194-200. doi: 10.1597/10-043.
Kouskoura T, Fragou N, Alexiou M, John N, Sommer L, Graf D, et al. The genetic basis of craniofacial and dental abnormalities. Schweiz Monatsschr Zahnmed. 2011;121(7-8):636-46. doi: 10.5167/uzh-50358.
Phan M, Conte F, Khandelwal KD, Ockeloen CW, Bartzela T, Kleefstra T, et al. Tooth agenesis and orofacial clefting: genetic brothers in arms? Hum Genet. 2016;135(12):1299-327. doi: 10.1007/s00439-016-1733-z.
Letra A, Menezes R, Granjeiro JM, Vieira AR. Defining subphenotypes for oral clefts based on dental development. J Dent Res. 2007 Oct;86(10):986-91. doi: 10.1177/154405910708601013.
da Silva AP, Costa B, de Carvalho Carrara CF. Dental anomalies of number in the permanent dentition of patients with bilateral cleft lip: radiographic study. Cleft Palate Craniofac J. 2008;45(5):473-6. doi: 10.1597/06-099.1.
Menezes R, Vieira AR. Dental anomalies as part of the cleft spectrum. Cleft Palate Craniofac J. 2008 Jul;45(4):414-9. doi: 10.1597/07-064.1.
Kuchler E, Motta L, Vieira A, Granjeiro J. Side of dental anomalies and taurodontism as potential clinical markers for cleft subphenotypes. Cleft Palate Craniofac J. 2011 Jan;48(1):103-8. doi: 10.1597/09-159.
Paranaíba LMR, Coletta RD, Swerts MSO. Quintino RP, Barros LM, Martelli-Júnior H. Prevalence of dental anomalies in patients with nonsyndromic cleft lip and/or palate in a brazilian population. Cleft Palate Craniofac J. 2013 Jul;50(4):400-5. doi: 10.1597/11-029.
Melo-Filho MR, Santos LAN, Martelli DRB, Silveira MF, Silva ME, Barros LM, et al. Taurodontism in patients with nonsyndromic cleft lip and palate in a Brazilian population: a case control evaluation with panoramic radiographs. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):744-50. doi: 10.1016/j.oooo.2015.08.005.
Sá J, Mariano LC, Canguçu D, Coutinho TS, Hoshi R, Medrado AP et al. Dental anomalies in a brazilian cleft population. Cleft Palate Craniofac J. 2016 Nov;53(6):714-9. doi: 10.1597/14-303.
Mangione F, Nguyen L, Foumou N, Bocquet E, Dursun E. Cleft palate with/without cleft lip in French children: radiographic evaluation of prevalence, location and coexistence of dental anomalies inside and outside cleft region. Clin Oral Investig. 2018 Mar;22(2):689-95. doi: 10.1007/s00784-017-2141-z.
Menezes C, de Arruda JA, Silva LV, Monteiro JL, Caribé P, Álvares P, et al. Nonsyndromic cleft lip and/or palate: A multicenter study of the dental anomalies involved. J Clin Exp Dent. 2018 Aug;10(8):e746-50. doi: 10.4317/jced.54926.
Aizenbud D, Coval M, Hazan-Molina H, Harari D. Isolated soft tissue cleft lip: epidemiology and associated dental anomalies. Oral Dis. 2011 Mar;17(2):221-31. doi: 10.1111/j.1601-0825.2010.01729.x.
Wu TT, Chen PK, Lo LJ, Cheng MC, Ko EW. The characteristics and distribution of dental anomalies in patients with cleft. Chang Gung Med J. 2011;34(3):306-14.
Schutte BC, Murray JC. The many faces and factors of orofacial clefts. Hum Mol Genet. 1999;8(10):1853-9. doi: 10.1093/hmg/8.10.1853.
Wejnert C, Pham H, Krishna N, Le B, DiNenno. Estimating design effect and calculating sample size for respondent-driven sampling studies of injection drug users in the United States. AIDS Behav. 2012;16(4):797-806. doi: 10.1007/s10461-012-0147-8.
Scott R, Turner CG. The anthropology of modern human teeth: dental morphology and its variation in recent human populations. Cambridge University Press; 2015.
Fekonja A. Prevalence of dental developmental anomalies of permanent teeth in children and their influence on esthetics. J Esthet Restor Dent. 2017;29(4):276-83. doi: 10.1111/jerd.12302.
Suzuki A, Nakano M, Yoshizaki K, Yasunaga A, Haruyama N, Takahashi I. A longitudinal study of the presence of dental anomalies in the primary and permanent dentitions of cleft lip and/or palate patients. Cleft Palate Craniofac J. 2017;54(3):309-20. doi: 10.1597/15-186.
Shapira Y, Lubit E, Kuftinec MM. Congenitally missing second premolars in cleft lip and cleft palate children. Am J Orthod Dentofacial Orthop. 1999;115(4):396-400. DOI: 10.1016/s0889-5406(99)70258-1.
Shapira Y, Lubit E, Kuftinec MM. Hypodontia in children with various types of clefts. Angle Orthod. 2000;70(1):16-21. doi: 10.1043/0003-3219(2000)070<0016:HICWVT>2.0.CO;2.
Karsten A, Larson M. The relationship between hypodontia in the second premolar region and heredity of cleft, lip and palate in children with isolated cleft palate. Swed Dent J. 2004;28(1):47-52.
Tortora C, Meazzini MC, Garattini G, Brusati R. Prevalence of abnormalities in dental structure, position, and eruption pattern in a population of unilateral and bilateral cleft lip and palate patients. Cleft Palate Craniofac J. 2008;45(2):154-62. doi: 10.1597/06-218.1.
Halpern RM, Noble J. Location and presence of permanent teeth in a complete bilateral cleft lip and palate population. Angle Orthod. 2010;80(3):591-6. doi: 10.2319/051009-250.1.
Bartzela TN, Carels CE, Bronkhorst EM, Rønning E, Rizell S, Kuijpers-Jagtman AM. Tooth agenesis patterns in bilateral cleft lip and palate. Eur J Oral Sci. 2010;118(1):47-52. doi: 10.1111/j.1600-0722.2009.00698.x.
Camporesi M, Baccetti T, Marinelli A, Defraia E, Franchi L. Maxillary dental anomalies in children with cleft lip and palate: a controlled study. Int J Paediatr Dent. 2010;20(6):442-50. doi: 10.1111/j.1365-263X.2010.01063.x.
Bartzela TN, Carels CE, Bronkhorst EM, Kuijpers-Jagtman AM. Tooth agenesis patterns in unilateral cleft lip and palate in humans. Arch Oral Biol. 2013;58(6):596-602. doi: 10.1016/j.archoralbio.2012.12.007.
Mikulewicz M, Ogiński T, Gedrange T, Berniczei-Royko A, Prussak E. Prevalence of second premolar hypodontia in the Polish cleft lip and palate population. Med Sci Monit. 2014 Mar;20:355-60. doi: 10.12659/MSM.890386.
Berniczei-Roykó Á, Tappe JH, Krinner A, Gredes T, Végh A, Gábor K, et al. Radiographic Study of the Prevalence and Distribution of Hypodontia Associated with Unilateral and Bilateral Clef Lip and Palate in a Hungarian Population. Med Sci Monit. 2016 Oct;22:3868-85. doi: 10.12659/msm.897957.
Schwartz JP, Lauris RC, Dalbén G, Garib DG. Second premolar agenesis as a subclinical phenotype of isolated cleft palate. Orthod Craniofac Res. 2017;20(1):1-7. doi: 10.1111/ocr.12134.
De Stefani A, Bruno G, Balasso P, Mazzoleni S, Baciliero U, Gracco A. Teeth agenesis evaluation in an Italian sample of complete unilateral and bilateral cleft lip and palate patients. Minerva Stomatol. 2018;67(4):156-64. doi: 10.23736/S0026-4970.18.04114-6.
Kim JW, Simmer JP, Lin BP, Hu JC. Novel MSX1 frameshift causes autosomal- dominant oligodontia. J Dent Res. 2006;85(3):267-71. doi: 10.1177/154405910608500312.
Vettore MV, Sousa Campos AE. Malocclusion characteristics of patients with cleft lip and/or palate. Eur J Orthod. 2011;33(3):311-7. doi: 10.1093/ejo/cjq078.
The Brazilian Journal of Oral Sciences uses the Creative Commons license (CC), thus preserving the integrity of the articles in an open access environment.
Downloads
