Bio-guided Isolation of Natural Iron Chelators from Mangifera indica Leaves and their Comparative Study to Desferal<SUP>®</SUP>

Sara N. Suliman; Mai H. ElNaggar; Marwa Elsbaey; Mohammed M. El-Gamil; Farid A. Badria

doi:10.20307/nps.2021.27.2.78

주제분류

...

저널정보

한국생약학회
Natural Product Sciences 학술저널
Natural Product Sciences Vol.27 No.2
2021.6 78 - 109 (32page)
DOI : 10.20307/nps.2021.27.2.78

저자정보

Sara N. Suliman (Mansoura University)
Mai H. ElNaggar (Kafrelsheikh university)
Marwa Elsbaey (Mansoura University)
Mohammed M. El-Gamil (Ministry of Justice)
Farid A. Badria (Mansoura University)

이용수
내서재: 0

내서재에 추가
되었습니다. 내서재에서
삭제되었습니다.

초록·키워드

오류제보하기

Through bio-guided isolation, two natural iron chelators were isolated from Mangifera indica L. leaves, identified as mangiferin (1) and iriflophenone-3-C-β-D-glucoside (2). Their iron-chelating activity was compared to that of Desferal^®using bipyridyl assay and EDTA as a standard. Mangiferin showed the highest activity with IC50 value of 0.385 mM (162.85 μg/mL). Furthermore, two combinations of mangiferin with Desferal® (M-D) and iriflophenone-3-C-β-D-glucoside (M-I) were evaluated. The results showed that mangiferin potentiated the iron chelation activity of Desferal^® about 46%, also that M-I combination is a promising candidate formula for iron chelation therapy. In addition, mangiferin and Desferal-iron complexes were prepared and characterized by IR, UV, and Mass spectra to compare their mode of chelation to iron. Their structural stability was studied by DFT calculations. Furthermore, they displayed increased ABTS antioxidant activity when bound to iron as compared to their free form, which enhances their pharmacological importance.

#Iron chelation #antioxidant activity #Desferal< #SUP> #®< #/SUP> #mangiferin #DFT