SHADBINDU TAILA NASYA IN ALLERGIC RHINITIS: A CONTROLLED CLINICAL TRIAL TO COMPARE ITS EFFICACY WITH TOPICAL AZELASTINE HYDROCHLORIDE NASAL SPRAY

With the aim to evaluate the efficacy of shadbindu taila Nasya and topical Azelastine hydrochloride nasal spray in the management of Allergic Rhinitis, a Single blind randomized clinical study was done. For the clinical study of Allergic Rhinitis 60 subjects was selected and studied. Subject’s fulfilling the criteria of diagnosis was studied irrespective of their religion, caste, sex and socio-economic status from shalakya-tantra (ENT) department of the institute after thorough scrutiny and proper consent in his/her language. The Subject’s having age between 20-60 yrs was selected for the clinical study. Detail history of the patient were elicited, pathological investigation including Hb, TLC, DLC, RBS and required radio logical investigation were done in a diagnostic Centre. The examination of the Nose is also carried out with the help of modern viewing techniques like Anterior Rhinoscopy, Posterior Rhinoscopy and Spatula Test etc. After observation and analytical study with the help of Wilcoxon sign rank test and Man-whiteny test it was concluded that in Allergic Rhinitis treatment with shadbindu taila Nasya shows more effective & long lasting Result in relieving sign and symptoms of Allergic Rhinitis than Azelastine hydrochloride nasal spray.


INTRODUCTION
The human life is full of competition due to which his life style has been completely changed, we has to face excessive exposure to pollution, cold Along with these factor consumption of chilled foods, cold drinks, ice cream etc. produces phlegm diseases which gives rise to respiratory tract diseases. As respiration is soul of physiological activity, Pranvaha strotas has its special importance. Dushti of Pranvaha Strotas may disturb the physiological activity of body. Nasa is commencement of pranvaha strotas. Nasa protects pranvaha strotas by adhering the harmful factors like pollen, dust to the mucous membrane, also humidifies air entering the nose and regulate the temperature of air entering the nose. Hence Pranvaha Strotas will be affected if physiological activity of protection of nose is not performed well. The pollution and the above said factors affect the nose and its mucosal membrane leading to various nasal diseases. Allergic Rhinitis is also a disease among them which is described by all Ayurvedacharya. In modern medical science, there is medical treatment for Allergic Rhinitis. Complete cure of these diseases is not yet possible by medical treatment.

MATERIALS AND METHODS
Patients having signs & symptoms of Allergic Rhinitis was randomly enrolled from the OPD of department of Shalakya-Tantra (ENT) of the institute after thorough scrutiny, proper consent & permission from ethical committee.

Grouping: 2 groups
Group A: The Subjects of this group was treated with shadbindu taila Nasya Group B: The Subjects of this group was treated with Azelastine hydrochloride nasal spray.

Examination of the patient
Nasal examination of the patient includes.
 Examination of external nose.  Examination of Vestibule.  Anterior Rhinoscopy  Posterior Rhinoscopy  Functional examination of nose.

RESULTS
In the Group A the Mean Foul Smell of Nose was observe to be 2.133 before treatment that reduced to 0.9333 after treatment (p value <0.05) , the Mean Anosmia of Nose was observe to be 1.633 before treatment that reduced to 1.567 after treatment (p value >0.05), the Mean Dryness of Nose was observe to be 2.5 before treatment that reduced to 0.6667 after treatment (p value <0.05),the Mean Crusting of Nose was observe to be 2.467 before treatment that reduced to 0.7000 after treatment (p value <0.05), the Mean Nasal Discharge of Nose was observe to be 1.333 before treatment that reduced to 0.5667 after treatment (p value <0.05), the Mean Blocking of Nose was observe to be 2.133 before treatment that reduced to 0.9000 after treatment (p value <0.05). In the Group B the Mean foul smell of Nose was observe to be 2.233 before treatment that reduced to 1.067 after treatment (p value <0.05), the Mean Anosmia of Nose was observe to be 1.500 before treatment that reduced to 1.400 after treatment ( Irritation of the skin produces vasodilatation in the locality. In neurology this reflex is known as Axon reflex. As shadbindu taila is being acidic in nature, it acts as irritant to nasal mucosal membrane, which produces vasodilatation. The acidic nature of shadbindu taila also inhibits the photolytic organism & also helps in removing crust. Thus shadbindu taila acts as vasodilator & Germicidal. Which are helpful in minimizing the symptoms of Allergic Rhinitis. From the above discussion, it is clear that Subjects having clinical features of Allergic Rhinitis are more significantly reduced in Group A than Group B which itself prove that treatment with shadbindu taila Nasya is better than treatment with Azelastine hydrochloride nasal spray in Allergic Rhinitis.