초록

Episodic memory, i.e. memorization of information within a spatiotemporal environment, is affected Alzheimer's disease (AD), but its impairment may also be occurred in the normal aging process. The purpose of this study is to analyze and evaluate memory in with Dementia of Alzheimer Type by examining their cognitive skills in episodic memory using the technique. This new method involves assessing the mental images the subject's own past in the mind like projected and movies. Three patients in the early stage of Dementia of Alzheimer Type, one with mild depression, and 2 healthy controls for comparison were asked to retrieve their episodic memory of the previous day, week, month, and a day testing day. The answers were then analyzed with regards to their specific features as emotional state, color, and time order. In the following day, the subjects were tasked to recall again the images they reproduced in the day's test order to observe of memory. Results showed that all 3 patients failed to arrange the retrieved images in time order and their images of the previous day were unclear in color and were stationary like photographs, even when they reproduced the mental images at much quantity as controls. patients could not remember particular events of yesterday, and only recalled the general occurrences of every day life. These results suggest that in the early stage of Dementia of Alzheimer Type, difficulties in the retrieval of recent episodic memory begin to primarily occur, and qualitative impairment happens earlier than quantitative.

키워드

Episodic memory, Autobiographical memory, Alzheimer's disease, The mental image

참고문헌(28)open

  1. [학술지] Braak, H / 1991 / Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections / Brain Pathology 1 (3) : 213 ~ 216

  2. [학술지] Fox, N. / 1996 / Protein folding, nucleation phenomena and delayed neurodegeneration in Alzheimer’s disease / Reviews in the Neurosciences 7 (1) : 21 ~ 28

  3. [학술지] Fox, N. / 1996 / “Atrophy of the hippocampal formation in early familial Alzheimer’s disease.” Longitudinal MRI study of as-risk members of a family with an amyloid precursor protein717Val-Gly mutation / Annals of the New York Academy of Sciences 17 (777) : 226 ~ 232

  4. [학술지] Laakso, M. P / 1998 / MRI of the hippocampus in Alzheimer's disease: sensitivity, specificity, and analysis of the incorrectly classified subjects / Neurobiology of Aging 19 (1) : 23 ~ 31

  5. [학술지] Vargha-Khadem F / 1997 / Differential effects of early hippocampal pathology on episodic and semantic memory / Science 18 (277) : 376 ~ 380

  6. [학술지] Nyberg, L / 1996 / Activation of medial temporal structures during episodic memory retrieval / Nature 380 : 715 ~ 717

  7. [단행본] Tulving, E / 1983 / Elements of Episodic Memory / Oxford University Press

  8. [학술지] Fink, G.R / 1996 / Cerebral representation of one’s own past; Neural networks involved in autobiographical memory / Journal of Neuroscience 16 (13) : 4275 ~ 4285

  9. [학술지] Kopelman, M. D. / 2001 / The loss of episodic memories in retrograde amnesia: single-case and group studies: Review / Philosophical Transactions of the Royal Society of London. Series B, Biological science 356 : 1409 ~ 1421

  10. [학술지] Conway, M. A / 2001 / Sensory-perceptual episodic memory and its context: autobiographical memory / Philosophical Transactions of the Royal Society of London. Series B, Biological science 356 : 1375 ~ 1384

  11. [학술지] Granholm, E / 1988 / Associative encoding and retrieval in Alzheimer's and Huntington's disease / Brain and Cognition 7 (3) : 335 ~ 347

  12. [학술지] Larsson, M / 1999 / Odor identification in normal aging and early Alzheimer’s disease: effect of retrieval support / Neuropsychogia 13 (1) : 47 ~ 53

  13. [학술지] Leube, D.T / 2003 / Successful episodic memory retrieval of newly learned faces activates a left fronto-parietal network / Cognitive Brain Research 18 (1) : 97 ~ 101

  14. [학술지] Greene, J. D. / 1996 / Identification of famous faces and famous names in early Alzheimer’s disease; Relationship to anterograde episodic memory and general semantic memory / Brain 119 : 111 ~ 128

  15. [학술지] Seltzer, B / 1974 / The temporal pattern of retrograde amnesia in Korsakoff's disease / Neurology 26 (4) : 527 ~ 530

  16. [학술지] Kopelman, M. D / 1989 / Remote and autobiographical memory, temporal context memory and frontal atrophy in Korsakoff and Alzheimer patients / Neuropsychologia 27 (4) : 437 ~ 460

  17. [학술지] Hodges, J. R / 1990 / Differential impairment of semantic and episodic memory in Alzheimer’s and Huntington’s disease: a controlled prospective study / Journal of neurology, neurosurgery and psychiatry 53 : 1089 ~ 1095

  18. [학술지] Graham, D. P / 2004 / The Alzheimer's Disease Assessment Scale-Cognitive subscale: normative data for older adult controls / Alzheimer Disease and Associated Disorders 18 (4) : 236 ~ 240

  19. [학술지] Hargrave, R. / 2002 / Impaired recognition of facial expression in Alzheimer’s disease / Journal of Neuropsychiatry and Clinical Neurosciences 14 (1) : 64 ~ 71

  20. [학술지] Dolan, R. J / 2000 / Dissociable temporal lobe activations during emotional episodic memory retrieval / Neuroimage 11 : 203 ~ 209

  21. [학술지] Cornoldi, C. / 1998 / Generation and retrieval of general, specific and autobiographical images representing concrete nouns / Acta Psychologica 72 : 25 ~ 39

  22. [학술지] Dror, I. E / 1994 / Mental imagery and aging / Psychology and Aging 9 (1) : 90 ~ 102

  23. [학술지] Cocude, M / 1997 / Latency and duration of visual mental images in normal and depressed subjects / Journal of Mental Images 21 : 127 ~ 142

  24. [학술지] De Beni, R. / 2007 / The generation and maintenance of visual mental images: evidence from image type and aging / Brain and Cognition 63 (3) : 271 ~ 278

  25. [학술지] Gardini, S / 2006 / Left mediotemporal structures mediate the retrieval of episodic autobiographical mental images / Neuroimage 30 (2) : 645 ~ 655

  26. [학술지] Nedjam, Z. / 2000 / Confabulation in a patient with fronto-temporal dementia and a patient with Alzheimer's disease / Cortex 36 (4) : 561 ~ 577

  27. [학술지] Cooper, J. M / 2006 / Provoked confabulations in Alzheimer's disease / Neuropsychologia 44 (10) : 1697 ~ 1707

  28. [학술지] Raes, F / 2005 / Autobiographical memory specificity and emotional abuse / British Journal of Clinical Psychological Society 44 : 133 ~ 138