This chapter discusses the prevalence of clinician burnout and its adverse consequences, describes the National Academy of Medicine’s Action Collaborative on Clinician Well-Being and Resilience, and helps the reader conduct a self-assessment of their own health and well-being. It also helps the reader evaluate their personal health and well-being related to the 10 dimensions of wellness and identify key strategies for improving their well-being in each of the wellness dimensions. Clinicians typically do a wonderful job of caring for their patients and family members, but they often do not prioritize their own self-care. Coupled with healthcare system challenges, including documentation requirements of electronic health records (which result in clinicians spending less time with their patients), maintenance of certification, loss of autonomy, unhealthy workplace cultures, and heavy workloads, these issues are a prescription for an unhealthy population and unsafe provision of care.