Sigma-1 receptor and the control of inflammation

Author: ORCID icon orcid.org/0000-0002-0342-8454
Rosen, Dorian, Pharmacology - School of Medicine, University of Virginia
Advisor:
Gaultier, Alban, MD-NESC Neuroscience, University of Virginia
Abstract:

The endoplasmic reticulum resident protein sigma-1 receptor is druggable and controls inflammatory outcomes during acute inflammatory insults.

Degree:
PHD (Doctor of Philosophy)
Keywords:
endoplasmic reticulum, sigma-1 receptor, inflammation, LPS, sepsis, multiple sclerosis, lipopolysaccharide, fecal induced peritonitis, fluvoxamine, XBP1, IRE1
Language:
English
Issued Date:
2019/05/01