Sensory response following knee joint damage in rabbits

Background:
Altered sensory information arising from damaged knee joint structures has been hypothesized as a
contributing factor to persistent muscle dysfunction following injury.
Methods:
Composite femoral nerve sensory signal was measured in 24 rabbits randomly allocated (8 per group) to
receive surgical anterior cruciate ligament (ACL) transection with or without autograft reconstruction or nothing
(control). Two-weeks after the intervention composite afferent signals were recorded from the femoral nerve.
Side-to-side ratios (surgical side vs contralateral heal
thy side) for peak femoral nerve afferent composite signal
were used for comparison.
Results:
Femoral nerve afferent signal ratios were signific
antly higher in the ACL-R (2.21 ± 0.74) group when
compared to the ACL-T (1.28 ± 0.61, P = 0.02) group and Control group (1.31 ± 0.78, P = 0.03).
Conclusion:
The magnitude of sensory information recorded on the femoral nerve is increased following ACL
injury and reconstruction surgery, but not after an isolated ACL injury in rabbits.

Hart, Joseph. "Sensory response following knee joint damage in rabbits." BMC Musculoskeletal Disorders 15.139 (2014).