An unusual case of persistent vomiting

Journal of Medical and Scientific Research case report A 40-year-old female, non-diabetic, non-hypertensive, presented with history of persistent vomitings since 6 months, 3-5 episodes of non-projectile, bilious vomitings per day, vomitus contains food particles and vomitings not related to food intake. History of constipation and increased frequency of urination present. History of significant weight loss present (lost 15kgs in 6 months). History of mild to moderate, non-progressive headache present since 3years but no history of visual disturbances. No history of odynophagia/ dysphagia/ dyspepsia/ cough/ haematemesis/ melena/ pain abdomen/ diarrhoea/ fever/ anorexia/ drug abuse/ native medicine abuse. Patient was treated outside with proton pump inhibitors, antacids and prokinetics. On examination, she was emaciated, dehydrated and very pale. Her blood pressure was 110/80 mmHg, and pulse rate was 88/min and regular. Cardiovascular, respiratory, and abdominal examinations were unremarkable. Laboratory work up revealed normal blood count except for Hb 9.9g/dl (microcytic, Abstract A 40-year-old female presented with history of persistent vomitings since 6 months. History of constipation and increased frequency of urination present. History of significant weight loss is present (lost 15kgs in 6 months). Work up for polyuria confirmed diabetes insipidus. Work up for diabetes insipidus revealed hypercalcemia secondary to primary hyperparathyroidism, resulting due to right parathyroid adenoma. Right parathyroid adenectomy was done and postoperatively patient developed hungry bone syndrome, which was treated by supplementing high dose of calcium and vitamin D supplementation.

Echocardiogram was normal.Vomitings and nephrogenic diabetes insipidus, secondary to hypercalcemia were confirmed.Since patient has anaemia, hypercalcemia and renal insufficiency, in differential diagnosis multiple myeloma, sarcoidosis, and hyperparathyroidism were considered.Work up revealed no lytic lesions in x-ray skull, serum 25-hydroxy vitamin D-19 ng/ml (30-100), serum phosphate 2.5mg/dl (2.5-4.5) and serum intact parathyroid hormone levels 1800 pg/ml (8-50).Work up for primary hyperparathyroidism revealed probable right superior parathyroid adenoma in ultrasonography of neck (Figure 1), which was confirmed with Sestamibi nuclear scan (Figure 2).Bone densitometry showed T scores at lumbar spine of -1.2 and at the total hip of -1.4.Patient was treated with intravenous crystalloids, steroids, and calcitonin prior to surgery.
Pre-operative serum calcium was 14 mg/dl.Right superior parathyroid adenectomy was done by general surgeon and post-operatively after 15 minutes, repeat serum intact PTH was advised and it was normal (56 pg/ml).Post-operative patient had hoarseness of voice secondary to injury to right recurrant laryngeal nerve.Post-operative serum calcium was 11.7 mg/dl, 9.6 mg/dl, 9.1mg/ dl on day 1,2,3 respectively.On post-operative Day 3, patient had paraesthesias all over the body and repeat serum calcium was advised (8.1mg/dl).It was treated with injection calcium gluconate and oral supplementation with pills containing calcium carbonate 500mg plus Calcitriol 0.25 mg thrice daily was advised.From POD 4 to POD 10, her serum calcium was between 7.1-7.8mg/dl despite of increasing number of calcium pills to 8 pills per day.Hungry bone syndrome was suspected and serum magnesium, serum phosphate and serum potassium were estimated.Serum magnesium was decreased 1.4 mg/dl, serum phosphate 2.1 mg/dl and serum potassium increased 5.7meq/l (serum creatinine-1.3mg/dl).Hypomagnesemia was corrected with magnesium sulphate and hyperkalemia was treated with potassium binding resins and salbutamol nebulization.With 4gm of calcium carbonate and calcitriol 2 µg on POD14, her calcium level was 8.0 mg/dl.Patient was discharged with oral calcium pills 3-3-2 per day (calcium carbonate 500mg, calcitriol 0.25mg) and potassium binding resins.Histopathology of excised parathyroid gland was suggestive of benign parathyroid adenoma.Genetic screening for MEN1 & 2 gene mutation was advised.

Discussion
Primary hyperparathyroidism is characterized by inappropriate, autonomous secretion of parathyroid hormone (PTH), mostly due to parathyroid adenoma and rarely due to hyperplasia or carcinoma.Most common cause of hypercalcemia is due to primary hyperparathyroidism [1].The incidence of primary hyperparathyroidism increases with age with peak in seventh decade, common in elderly women while it is more or less equal in men and women before 45 years age [2].
Asymptomatic hyperparathyroidism is prevalent in developed countries because of increase in biochemical screening, contrary to this symptomatic hyperparathyroidism (nephrolithiasis, bone pains, fracture) is more common in India [3,4].The clinical presentation of primary hyperparathyroidism in India as per systematic review of Pradeep et al. [4], is bone disease (77%), proximal muscle weakness (54%), brown tumours (42%), fractures (40%), renal disease (36%), psychiatric symptoms (26%), pancreatitis (15%), and asymptomatic (5.6%).In India, gastrointestinal presentations of hyperparathyroidism such as anorexia, nausea, vomiting, constipation and pain abdomen were more prevalent in the last decade [5].Viral N et al. [5] found in their study that presentation with nausea, vomiting (39%), constipation (48%), and polyuria (28%) in the last decade.Our patient even though presented with nausea, vomitings, she also had constipation and polyuria.Hyperparathyroidism usually causes weight gain, in contrast weight loss in our patient was because of dehydration due to persistent vomitings daily for 6 months.
Definitive treatment of primary hyperparathyroidism is parathyroidectomy.Patients with mild hypercalcemia (<12 mg/dl) can be directly posted for surgery while correction of calcium before surgery is preferred in case of moderate to severe hypercalcemia to avoid complications.Postoperative hypocalcaemia is common, following parathyroidectomy, which usually starts on POD3.
Hungry bone syndrome (HBS) was noticed in 24% to 82% of the cases postoperatively [3,6].HBS refers to the profound (serum calcium <8.4 mg/dl) and prolonged (longer than 4th day post-operatively) hypocalcaemia, which follows parathyroidectomy.This is usually associated with skeletal manifestations in majority of cases, however this was reported in less than 6% of cases without radiological evidence of PTH related bone disease.The risk factors for hungry bone syndrome in our case were due to very high preoperative parathyroid hormone levels (1800 pg/ml), coexistent vitamin d deficiency (19 ng/ml), and high preoperative serum calcium levels (14 mg/ dl).Treatment of HBS is replenishing the calcium deficit by using high doses of calcium which varies between 6 and 12 g/day [7] and supplementation of vitamin D. Correction of magnesium deficiency is required for resolution of the hypocalcaemia.Calcium levels may return to normal after few weeks to months in HBS.