ISHS Acta Horticulturae 1106: XXIX International Horticultural Congress on Horticulture: Sustaining Lives, Livelihoods and Landscapes (IHC2014): VI International Symposium on Human Health Effects of Fruits and Vegetables (FAVHEALTH 2014)
Potential antidiabetic activity of naturally occurring compounds by enzyme α-glucosidase inhibition |
| Author: | S. Islam |
| Keywords: | natural compounds, antidiabetic, inhibition, anthocyanins, polyphenols, thiols |
| DOI: | 10.17660/ActaHortic.2015.1106.26 |
| Abstract:
Fourteen naturally occurring compounds and two derivatives of naturally occurring compounds were tested for inhibitory activity with the enzyme α-glucosidase. These compounds included anthocyanins, thiol derivatives, and cinnamic acid. Acarbose was used as the standard. Rutin and tannic acid displayed the highest inhibitory effect (almost 90%), whereas thiols had a neglected effect. Compared to acarbose, rutin and tannic inhibitory effects were 1.6% higher. Concerning anthocyanins, pelargodin had a comparable effect as acarbose and the other anthocyanins tested displayed a less effect. More generally, the ortho-diphenolic structures as aglycones or free forms, such as cyanidin, caffeic acid and quercetin, were less active certainly due to their high oxidability in the test solutions. The glycosylation confer a better stability to the polyphenol, found in rutin, and contribute to a better effect. | |
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