Incidence of Incidental Findings on Pediatric Oncologic PET/CT

The purpose of this study is to determine the incidence and significance of incidental findings on pediatric oncologic PET/CT. A retrospective analysis of all PET/CT scans obtained at Helen DeVos Children’s Hospital between 2004-2008 in pediatric oncology patients was performed. Specific data points for study including DOB, primary diagnosis, secondary diagnosis, treatment status (chemotherapy and radiation) and PET/CT findings were obtained. Studies were reviewed and findings confirmed with board certified Nuclear Medicine and Pediatric Radiologists. Total of 104 patients with various tumors/malignancies underwent 323 integrated PET/CT for staging or monitoring. Of these 104 patients, 71 (68%) had at least one incidental finding present on the PET/ CT and 116 of 323 (36%) studies had at least 1 incidental CT finding. In conclusion, our retrospective study shows that careful evaluation of especially the CT component of integrated PET/CT scans provides clinically important information which may necessitate additional workup or treatment.


Introduction
PET with the glucose analog 18F-FDG is increasingly recognized as a powerful tool in evaluating patients with various malignant tumors [1][2][3]. Recently, combined PET and CT systems (PET/CT) have emerged as promising imaging modalities and are being more routinely used in clinical situations [4][5][6]. PET/CT offers routine precise fusion of metabolic PET images with high-quality CT images.
Routine PET combines information from emission scans obtained with F-FDG and from transmission scans obtained with germanium-68 or cesium-137 for attenuation correction. CT has been adapted as the transmission scan, and the adaptation has enabled acquisition of fused PET/CT images. The CT component of PET/CT is also whole-body CT, and abnormalities that can affect treatment decisions or warrant additional treatment may be present. Therefore, it is important that CT images be interpreted in addition to PET images.
The purpose of our study was to report the prevalence of abnormalities that do not show increased F-FDG uptake on the CT component of integrated PET/CT in pediatric oncology patients.

Discussion
The CT component of PET/CT, even if performed for purely anatomic localization, must be comprehensively interpreted to accurately identify all potentially important findings [9]. Evidence in our study shows that careful evaluation of the CT component of integrated PET/CT scans provides clinically important information.
Our classification of abnormalities as being of major, moderate, or minor clinical importance, although somewhat subjective to the pediatric population, was used in an attempt to quantify the significance of abnormalities present on the PET/CT studies.     Minimal downward displacement of cerebellar tonsils 1 1 Post treatment changes in thalamus and midbrain 1 1

Schmorls nodes 1 1
Focal hypodensity in left obturator 1 1 Large lytic lesion in inferior pubic ramus 1 1 In any patient with an underlying malignancy, there should be a heightened awareness to identify metastatic disease. Lymphoma, sarcoma, and testicular carcinoma, among others, have a high tendency to metastasize to the lungs. In our study, we had 15 patients with incidental pulmonary nodules on the CT thorax component of PET/CT. These nodules were identified and followed up closely on consequent PET/CT studies.       establishes that PET/CT imaging is a very valuable tool for diagnosing additional pathology that may necessitate additional workup or treatment.
Most of our patients are in a hypercoagulable state due to their malignancy. A hypercoagulable prothrombotic state of malignancy occurs due to the ability of tumor cells to activate the coagulation system and it has been estimated that hypercoagulation accounts for a significant percentage of mortality and morbidity in cancer patients [10]. In our study, we identified 8 patients with a thrombus. Twelve patients were identified with renal hypodensities that could represent either simple cysts or small infarcts.
Oncology patients are also in an immunosuppressed state and their chances of acquiring an atypical infection is high. We identified a total of 15 patients with pneumonia and a total of 25 patients with paranasal sinus disease. Four patients had pleural effusions.
The CT component of PET/CT is also very useful for identifying radiation/chemotherapy induced changes. It is important to become aware of these changes so that these are not confused with tumor or reoccurrence of tumor. We had three patients with enteritis of colon, 3 patients with focal fatty liver, two patients with dermal changes (breast and buttocks), one patient with bladder wall thickening, and one patient with radiation induced changes in the brain, two patients with hydronephrosis, and one patient with pericardial effusion.
Finally, it is good to identify findings that are of minor clinical relevance because if symptoms due to these abnormalities develop, it is likely that the diagnosis will be reached more quickly if the presence of the abnormalities is known [11]. We identified 5 patients with spondylosis, 1 patient with a large lytic lesion in the inferior public ramus (likely an enchondroma), two patients with cholethiasis, one patient with a non-obstructive renal calculi.

Conclusion
Our retrospective study indicates that incidental findings are common and most had moderate or major significance. This