Czech J. Food Sci., 2006, 24(2):72-83 | DOI: 10.17221/3302-CJFS

Antimutagenic effect of curcumin and its effect on the immune response in mice

Petr ©merák1, Zdeňka Polívková1, Helena ©estáková2, Rudolf ©tětina3, Ivo Bárta1, Martina Langová1, Bohumil Turek2, Jiřina Bártová4
1 Department of General Biology and Genetics and 4Department of General Hygiene, Center of Biomedical Science, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
2 National Institute of Public Health, Prague, Czech Republic
3 Faculty of Military Health Sciences, Department of Toxicology, Hradec Kralové, Czech Republic

A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities. Among the most extensively investigated and well-defined dietary chemopreventives is curcumin. Using the Ames test and in vivo micronucleus test, chemiluminescence test, blastic transformation test, and comet assay, we examined the antimutagenic effects of the chemically identified chemoprotective substance curcumin (diferuloylmethane) in the pure form on mutagenicity induced by three reference mutagens: aflatoxin B1 (AFB1), 2-amino-3-metylimidazo[4,5-f]quinoline (IQ), and N-nitroso-N-metylurea (MNU), and the effect of curcumin on the immunosuppression caused by these mutagens. Curcumin in the pure form showed a clear antimutagenic and immunomodulatory activities on mutagenicity and immunosuppression induced by reference mutagens.

Keywords: curcumin; antimutagenic effects; response of immune; Ames test; micronucleus test; comet assay; chemiluminescence; blastic transformation tests

Published: April 30, 2006  Show citation

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©merák P, Polívková Z, ©estáková H, ©tětina R, Bárta I, Langová M, et al.. Antimutagenic effect of curcumin and its effect on the immune response in mice. Czech J. Food Sci.. 2006;24(2):72-83. doi: 10.17221/3302-CJFS.
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