Vet Med - Czech, 2017, 62(4):179-185 | DOI: 10.17221/176/2015-VETMED

Comparative use of dimethyl sulphoxide (DMSO) in different animal speciesReview

G.M. Madruga1, L.Z. Crivellenti*,2, S. Borin-Crivellenti2,3, C.A. Cintra2, L.G. Gomes1, P.R. Spiller1
1 Federal University of Mato Grosso (UFMT), Cuiaba, Brazil
2 Franca University (UNIFRAN), Franca, Brazil
3 Federal University of Uberlandia (UFU), Uberlandia, Brazil

Dimethyl sulphoxide has a variety of biological effects that have made it the subject of numerous pharmacological studies. The first dimethyl sulphoxide therapeutic indication approved by the United States Food and Drug Administration (FDA) in 1978 was for intravesical instillation in cases of interstitial cystitis. Since then, due to its distinctive properties, it has been the subject of studies in several areas. This review describes indications, adverse effects and contraindications, as takes a critical approach to the main articles addressing the clinical use of dimethyl sulphoxide.

Keywords: dimethyl sulfoxide; indications; adverse effects; contraindications; interstitial cystitis; therapeutic properties; cryopreservation; DMSO toxicity; experimental models

Published: April 30, 2017  Show citation

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Madruga GM, Crivellenti LZ, Borin-Crivellenti S, Cintra CA, Gomes LG, Spiller PR. Comparative use of dimethyl sulphoxide (DMSO) in different animal species. Vet Med-Czech. 2017;62(4):179-185. doi: 10.17221/176/2015-VETMED.
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    References

    1. Bakar B, Kose EA, Sonal S, Alhan A, Kilinc K, Keskil IS (2012): Evaluation of neurotoxicity of DMSO infused into the carotid artery of rat. Injury 43, 315-322. Go to original source... Go to PubMed...
    2. Baliga R, Zhang Z, Baliga M, Ueda N, Shah SV (1998): In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity. Kidney International 53, 394-401. Go to original source... Go to PubMed...
    3. Benekli M, Anderson B, Wentling D, Bernstein S, Czuczman M, Mccarthy P (2000): Severe respiratory depression after dimethylsulphoxide-containing autologous stem cell infusion in a patient with AL amyloidosis. Bone Marrow Transplantation 25, 1299-1301. Go to original source... Go to PubMed...
    4. Brayton CF (1986): Dimethyl sulfoxide (DMSO): a review. The Cornell Veterinarian 76, 76-90.
    5. Capriotti K, Capriotti JA (2012): Dimethyl sulfoxide history, chemistry, and clinical utility in dermatology. The Journal of Clinical and Aesthetic Dermatology 5, 24-26.
    6. Carpenter JF, Dawson PE (1991): Quantitation of dimethyl sulfoxide in solutions and tissues by high-performance liquid chromatography. Cryobiology 28, 210-215. Go to original source... Go to PubMed...
    7. Chaloupka JC, Vinuela F, Vinters HV, Robert J (1994): Technical feasibility and histopathologic studies of ethylene vinyl copolymer (EVAL) using a swine endovascular embolization model. American Journal of Neuroradiology 15, 1107.
    8. Chen D, Song D, Wientjes MG, Au JL (2003): Effect of dimethyl sulfoxide on bladder tissue penetration of intravesical paclitaxel. Clinical Cancer Research 9, 363-369.
    9. Crivellenti LZ (2015): Nephrology and urology (in Portuguese). In: Crivellenti LZ, Borin-Crivellenti S (eds): Routine Cases in Veterinary Medicine for Small Animals. 2nd edn. MedVet Ltda, Sao Paolo. 418-786.
    10. Crivellenti LZ, Borin-Crivellenti S, Carvalho MB (2013): Toxicity of dimethyl sulfoxide in healthy dogs and with chronic kidney disease. Ciencia Rural 43, 1831-1837. Go to original source...
    11. David NA (1972): The pharmacology of dimethyl sulfoxide 6544. Annual Review of Pharmacology 12, 353-374. Go to original source... Go to PubMed...
    12. Davidson M, Nelms SR (2013): 21. Disease of lens and cataract formation. In: Gelatt KN (ed.): Veterinary Ophthalmology. 5th edn. John Wiley and Sons, Iowa. 1216 pp.
    13. Duimel-Peeters IGP, Houwing RH, Teunissen CP, Berger MPF, Snoeckx LHEH, Halfens RJG (2003): A systematic review of the efficacy of topical skin application of dimethyl sulfoxide on wound healing and as an anti-inflammatory drug. Wounds-A Compendium of Clinical Research and Practice 15, 361-370.
    14. Egorin MJ, Rosen DM, Sridhara R, Sensenbrenner L, Cottler-Fox M (1998): Plasma concentrations and pharmacokinetics of dimethylsulfoxide and its metabolites in patients undergoing peripheral-blood stem-cell transplants. Journal of Clinical Oncology 16, 610-615. Go to original source... Go to PubMed...
    15. Ferm VH (1966): Congenital malformations induced by dimethyl sulphoxide in the golden hamster. Journal of Embryology and Experimental Morphology 16, 49-54. Go to original source...
    16. Garcia-Aguirre JG, Mercado HQ, Reyes AR, Sahd JL (2008): Histopathological analysis of the effect of dimethyl sulfoxide (DMSO) in an experimental model of retinal ischemia (in Spanish). Revista Mexicana de Oftalmologia 82, 1-4.
    17. Gurtovenko AA, Anwar J (2007): Modulating the structure and properties of cell membranes: The molecular mechanism of action of dimethyl sulfoxide. Journal of Physical Chemistry B 111, 10453-10460. Go to original source... Go to PubMed...
    18. Hanslick JL, Lau K, Noguchi KK, Olney JW, Zorumski CF, Mennerick S, Farber NB (2009): Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system. Neurobiology of Disease 34, 1-10. Go to original source... Go to PubMed...
    19. Hung MJ, Chen YT, Shen PS, Hsu ST, Chen GD, Ho ES (2012): Risk factors that affect the treatment of interstitial cystitis using intravesical therapy with a dimethyl sulfoxide cocktail. International Urogynecology Journal 23, 1533-1539. Go to original source... Go to PubMed...
    20. Jacob SW, De la Torre JC (2009): Pharmacology of dimethyl sulfoxide in cardiac and CNS damage. Pharmacological Reports 61, 225-235. Go to original source... Go to PubMed...
    21. Jo SK, Hu XZ, Yuen PST, Aslamkhan AG, Pritchard JB, Dear JW, Star RA (2004): Delayed DMSO administration protects the kidney from mercuric chloride-induced injury. Journal of the American Society of Nephrology 15, 2648-2654. Go to original source... Go to PubMed...
    22. Kim R, Liu WJ, Chen X, Kreder KJ, Luo Y (2010): Intravesical dimethyl sulfoxide inhibits acute and chronic bladder inflammation in transgenic experimental autoimmune cystitis models. Journal of Biomedicine and Biotechnology 2011, 1-9. Go to original source... Go to PubMed...
    23. Lind RC, Gandolfi AJ (1997): Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney. Toxicology and Applied Pharmacology 142, 201-207. Go to original source... Go to PubMed...
    24. Lishner M, Lang R, Kedar I, Ravid M (1985): Treatment of diabetic perforating ulcers (mal perforate) with local dimethyl sulfoxide. Journal of the American Geriatrics Society 33, 41-43. Go to original source... Go to PubMed...
    25. Lotan D, Kaplan BS, Fong JSC, Goodyer PR, Dechadarevian JP (1984): Reduction of protein excretion by dimethyl sulfoxide in rats with passive Heymann nephritis. Kidney International 25, 778-788. Go to original source... Go to PubMed...
    26. Melchior D, Packer CS, Johnson TC, Kaefer M (2003): Dimethyl sulfoxide: Does it change the functional properties of the bladder wall? Journal of Urology 170, 253-258. Go to original source... Go to PubMed...
    27. Notman R, den Otter WK, Noro MG, Briels WJ, Anwar J (2007): The permeability enhancing mechanism of DMSO in ceramide bilayers simulated by molecular dynamics. Biophysical Journal 93, 2056-2068. Go to original source... Go to PubMed...
    28. Paes AC, Cortes JA (2008): Isoniazid potentiation of the dimethyl sulfoxide (DMSO) in the treatment of hamsters (Mesocricetus auratus) experimentally infected with Mycobacterium (AN5) (in Portuguese). Veterinary and Animal Sciences 15, 486-495. Go to original source...
    29. Paulin HJ, Murphy JB, Larson RE (1966): Determination of dimethyl sulfoxide in plasma and cerebrospinal fluid by gas-liquid chromatography. Analytical Chemistry 38, 651-652. Go to original source... Go to PubMed...
    30. Preisler HD, Christoff G, Reese P, Pavelic P, Rustum Y (1978): Friend leukemia cells: Relationship between differentiation, clonogenicity and malignancy. Cell Differentiation 7, 1-10. Go to original source... Go to PubMed...
    31. Raskin DJ, Sullivan KH, Rappaport NH (1983): The role of topical dimethyl sufoxide in burn wounds infection: evaluation in the rat. Annals of the New York Academy of Sciences 411, 105-109. Go to original source... Go to PubMed...
    32. Ravid M, Shapira J, Lang R, Kedar I (1982): Prolonged dimethylsulphoxide treatment in 13 patients with systemic amyloidosis. Annals of the Rheumatic Diseases 41, 587- 592. Go to original source... Go to PubMed...
    33. Rijtema M, Mosig D, Drukker A, Guignard JP (1999): The effects of dimethyl sulfoxide on renal function of the newborn rabbit. Biology of the Neonate 76, 355-361. Go to original source... Go to PubMed...
    34. Santos NC, Figueira-Coelho J, Martins-Silva J, Saldanha C (2003): Multidisciplinary utilization of dimethyl sulfoxide: pharmacological, cellular, and molecular aspects. Biochemical Pharmacology 65, 1035-1041. Go to original source... Go to PubMed...
    35. Scheinberg MA, Pernambuco JC, Benson MD (1984): DMSO and colchicine therapy in amyloid disease. Annals of the Rheumatic Diseases 43, 421-423. Go to original source... Go to PubMed...
    36. Sehtman L (1975): Dimethyl sulfoxide therapy in various dermatological disorders. Annals of the New York Academy of Sciences 243, 395-402. Go to original source... Go to PubMed...
    37. Senior D (2006): Feline lower urinary tract disease. The Latin American Veterinary Conference TLAVC, Lima, Peru, 29. September-2. October 2006. 7-12. Available at http://www.ivis.org/proceedings/wsava/2006/lecture27/Senior1.pdf?LA=1.
    38. Soto FRM, Viana WG, Mucciolo GCB, Hosomi FYM, Vannucchi CI, Mazzei CP, Eyherabide AR, Lucio CD, Dias RA, de Azevedo SS (2009): Evaluation of efficacy and safety of zinc gluconate associated with dimethyl sulphoxide for sexually mature canine males chemical neutering. Reproduction in Domestic Animals 44, 927-931. Go to original source... Go to PubMed...
    39. Stav K, Beberashvili I, Lindner A, Leibovici D (2012): Predictors of response to intravesical Dimethyl-sulfoxide cocktail in pacients with interstitial cystitis. Urology 80, 61-65. Go to original source... Go to PubMed...
    40. Stone RW (1993): Clinical updates on the use of dimethyl sulfoxide. Canine Practice 18, 16-18.
    41. Sum AK, de Pablo JJ (2003): Molecular simulation study on the influence of dimethylsulfoxide on the structure of phospholipid bilayers. Biophysical Journal 85, 3636-3645. Go to original source... Go to PubMed...
    42. Wang CC, Lin SY, Lai YH, Liu YJ, Hsu YL, Chen JJ (2012): Dimethyl Sulfoxide promotes the multiple functions of tumor supressor HLJ1 through activator protein-1 activation in NSCLC cells. PloS ONE 7, doi: 10.1371/journal.pone.0033772. Go to original source... Go to PubMed...
    43. Ware WA (2006): Glomerulopathy (in Portuguese). In: Nelson RW, Couto CG (eds): Small Animal Internal Medicine. 3rd edn. 575-582.
    44. Wood DC, Weber FS, Palmquist MA (1971): Continued studies in the toxicology of dimethyl sulfoxide (DMSO). The Journal of Pharmacology and Experimental Therapeutics 177, 520-527.
    45. Zenhausern R, Tobler A, Leoncini L, Hess OM, Ferrari P (2000): Fatal cardiac arrhythmia after infusion of dimethyl sulfoxide-cryopreserved hematopoietic stem cells in a patient with severe primary cardiac amyloidosis and endstage renal failure. Annals of Hematology 79, 523-526. Go to original source... Go to PubMed...

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