The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Pressure-Volume Relationship and Renal Function in Chronic Glomerulonephritis Patients
YASUHIKO SASAKIMASATSUGU MIKAMIYUTAKA HORINOTAKASHI FURUYAMARYUJI SHIOJI
Author information
JOURNAL FREE ACCESS

1979 Volume 128 Issue 4 Pages 305-312

Details
Abstract

The relationship between the diastolic arterial pressure and blood volume or plasma volume (pressure-volume relationship) and that between plasma volume and endogenous creatinine clearance (Ccr) were investigated in chronic glomerulonephritis patients. Patients were divided into two groups, normotensive and hypertensive. In the normotensives (diastolic pressure_??_80 mmHg, Ccr=90±5 ml/min), the diastolic pressure correlated negatively with blood volume and plasma volume. In the hypertensives (diastolic pressure>80 mmHg, Ccr=66±9ml/min), the diastolic pressure positively correlated with blood volume and plasma volume. In the normotensives, there was a positive correlation between plasma volume (ml) (PV) and Ccr; the relation was: Ccr=0.068 PV0.91....(l). On the other hand, in the hypertensives, PV tended to increase with a decrease in Ccr, but there was no significant correlation between the two. If glomerular filtration rate (GFR) is a function of PV, as can be presumed from the relation shown in equation (1), and pressure diuresis is caused mainly by a decrease in tubular reabsorption with an increase in peritubular capillary pressure, urine volume (V), as a function of arterial pressure (AP) and that of PV, can be expressed as: V=f1(AP)f2(PV), where df1/dAP and df2/dPV are positive. Using this relation in the stationary state of body fluid volume (V=constant), the turn of pressurevolume relationship from negative to positive in chronic glomerulonephritis patients seems to be caused by the transform of f2 in the normal range of arterial pressure into f3 (df3/dPV<0, a new PV-GFR relation) in the higher range of arterial pressure, provided that df1/dAP is positive in both normotensive and hypertensive patients.

Content from these authors
© Tohoku University Medical Press
Next article
feedback
Top